Moringa isothiocyanate-1 regulates Nrf2 and NF-κB pathway in response to LPS-driven sepsis and inflammation.

Autor: Badi Sri Sailaja, Rohit Aita, Shane Maledatu, David Ribnicky, Michael P Verzi, Ilya Raskin

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0248691 (2021)

This study aims to document the dual mode of pharmacological action of moringa isothiocyanate-1 (MIC-1) derived from seeds of Moringa oleifera Lam. Oral administration of chemically stable MIC-1 (80 mg/kg) significantly reduced the expression of infl

Externí odkaz: https://doaj.org/article/e68835a7420d42aeb2b84afb0938afd8

Differential Association of Chromatin Proteins Identifies BAF60a/SMARCD1 as a Regulator of Embryonic Stem Cell Differentiation

Autor: Adi Alajem, Alva Biran, Arigela Harikumar, Badi Sri Sailaja, Yair Aaronson, Ilana Livyatan, Malka Nissim-Rafinia, Andreia Gianotti Sommer, Gustavo Mostoslavsky, Vincent R. Gerbasi, Daniel E. Golden, Arnab Datta, Siu Kwan Sze, Eran Meshorer

Publikováno v: Cell Reports, Vol 10, Iss 12, Pp 2019-2031 (2015)

Embryonic stem cells (ESCs) possess a distinct chromatin conformation maintained by specialized chromatin proteins. To identify chromatin regulators in ESCs, we developed a simple biochemical assay named D-CAP (differential chromatin-associated prote

Externí odkaz: https://doaj.org/article/a0bea8c8536144c6b4802789f2aae367

Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells.

Autor: Cesar A Sommer, Constantina Christodoulou, Andreia Gianotti-Sommer, Steven S Shen, Badi Sri Sailaja, Hadas Hezroni, Avrum Spira, Eran Meshorer, Darrell N Kotton, Gustavo Mostoslavsky

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51711 (2012)

Delivery of the transcription factors Oct4, Klf4, Sox2 and c-Myc via integrating viral vectors has been widely employed to generate induced pluripotent stem cell (iPSC) lines from both normal and disease-specific somatic tissues, providing an invalua

Externí odkaz: https://doaj.org/article/3ab5197505344e6796c693c4b354202e

PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation

Autor: Eran Meshorer, Badi Sri Sailaja, Gajendra Kumar Azad, Alva Biran, David T. Brown, Takumi Takizawa, Malka Nissim-Rafinia, Kenji Ito, Yasuhiro Yamada

Publikováno v: The Journal of Cell Biology

Neuronal stimulation leads to the expression of immediate early genes (IEGs). Azad et al. show that neuronal depolarization induces replacement of the linker histone H1 by PARP1 at IEG promoters in a manner that requires H1 phosphorylation and H1 pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b70d7479c58fc32aba476ec4ef99e31

Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation

Autor: Styliani Markoulaki, Raghu Ram Edupuganti, Siu Kwan Sze, Gajendra Kumar Azad, Arigela Harikumar, Malkiel A. Cohen, Jung Eun Park, Yair Aaronson, Alva Biran, Malka Nissim-Rafinia, Eran Meshorer, Rudolf Jaenisch, Chikdu S. Shivalila, Badi Sri Sailaja

Publikováno v: Stem Cell Reports
Elsevier
Stem Cell Reports, Vol 9, Iss 4, Pp 1291-1303 (2017)
Stem Cell Reports, 9, 4, pp. 1291-1303
Stem Cell Reports, 9, 1291-1303

Embryonic stem cells (ESCs) are regulated by pluripotency-related transcription factors in concert with chromatin regulators. To identify additional stem cell regulators, we screened a library of endogenously labeled fluorescent fusion proteins in mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aeb47533a8bc99132431157745017a7
https://pubmed.ncbi.nlm.nih.gov/28966118