3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors.

Autor: Badder LM; Cardiff University School of Biosciences, Cardiff, Wales, United Kingdom.; European Cancer Stem Cell Research Institute (ECSCRI), Cardiff University, Cardiff, Wales, United Kingdom., Hollins AJ; Cardiff University School of Biosciences, Cardiff, Wales, United Kingdom.; European Cancer Stem Cell Research Institute (ECSCRI), Cardiff University, Cardiff, Wales, United Kingdom., Herpers B; OcellO B.V., Leiden, The Netherlands., Yan K; OcellO B.V., Leiden, The Netherlands., Ewan KB; Cardiff University School of Biosciences, Cardiff, Wales, United Kingdom., Thomas M; Cellesce Ltd, Cardiff Medicentre, Heath Park, Cardiff, United Kingdom., Shone JR; Cardiff University School of Biosciences, Cardiff, Wales, United Kingdom., Badder DA; Cellular Pathology Department, University Hospital for Wales, Cardiff, United Kingdom., Naven M; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom., Ashelford KE; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom., Hargest R; Department of Colorectal Surgery, University Hospital of Wales, Cardiff, United Kingdom.; Division of Cancer and Genetics, CCMRC, Henry Wellcome Building, Cardiff University, Cardiff, United Kingdom., Clarke AR; European Cancer Stem Cell Research Institute (ECSCRI), Cardiff University, Cardiff, Wales, United Kingdom., Esdar C; Biopharma, Merck Healthcare KGaA, Research & Development, Darmstadt, Germany., Buchstaller HP; Biopharma, Merck Healthcare KGaA, Research & Development, Darmstadt, Germany., Treherne JM; Cellesce Ltd, Cardiff Medicentre, Heath Park, Cardiff, United Kingdom., Boj S; Hubrecht Organoid Technology, Utrecht, The Netherlands., Ramezanpour B; Hubrecht Organoid Technology, Utrecht, The Netherlands., Wienke D; Biopharma, Merck Healthcare KGaA, Research & Development, Darmstadt, Germany., Price LS; OcellO B.V., Leiden, The Netherlands., Shaw PH; Velindre Cancer Centre, Cardiff, Wales, United Kingdom., Dale TC; European Cancer Stem Cell Research Institute (ECSCRI), Cardiff University, Cardiff, Wales, United Kingdom.

Publikováno v: PloS one [PLoS One] 2020 Aug 18; Vol. 15 (8), pp. e0235319. Date of Electronic Publication: 2020 Aug 18 (Print Publication: 2020).