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Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights.

Autor: Badawi WA; Department of Pharmaceutical Chemistry, Damanhour University, Damanhour, Buhaira, Egypt., Rashed M; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Nocentini A; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy.; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, Italy., Bonardi A; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy.; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, Italy., Abd-Alhaseeb MM; Department of Pharmacology and Toxicology, Damanhour University, Damanhour, Buhaira, Egypt., Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Veerakanellore GB; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA., Majrashi TA; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia., Elgendy B; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St. Louis, MO, USA.; Chemistry Department, Faculty of Science, Benha University, Benha, Egypt., Gratteri P; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Sesto Fiorentino, Italy., Supuran CT; Department of Neurofarba, Section of Pharmaceutical and Nutraceutical Sciences, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Polo Scientifico, Firenze, Sesto Fiorentino, Italy., Eldehna WM; Department of Pharmaceutical Chemistry, Kafrelsheikh University, Kafrelsheikh, Egypt., Elagawany M; Department of Pharmaceutical Chemistry, Damanhour University, Damanhour, Buhaira, Egypt.

Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2201407.

New functionalized 6-thienylpyrimidine-5-carbonitriles as antiproliferative agents against human breast cancer cells.

Autor: AboulWafa OM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., Daabees HMG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt., Hammad A; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Badawi WA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Nov; Vol. 354 (11), pp. e2100177. Date of Electronic Publication: 2021 Aug 04.