A validated generally applicable approach using the systematic assessment of disease modules by GWAS reveals a multi-omic module strongly associated with risk factors in multiple sclerosis.

Autor: Badam, Tejaswi V. S.^1,2 (AUTHOR), de Weerd, Hendrik A.^1,2 (AUTHOR), Martínez-Enguita, David² (AUTHOR), Olsson, Tomas³ (AUTHOR), Alfredsson, Lars^3,4 (AUTHOR), Kockum, Ingrid³ (AUTHOR), Jagodic, Maja³ (AUTHOR), Lubovac-Pilav, Zelmina¹ (AUTHOR), Gustafsson, Mika² (AUTHOR) mika.gustafsson@liu.se

Publikováno v: BMC Genomics. 8/30/2021, Vol. 22 Issue 1, p1-13. 13p.

CD4⁺ T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases.

Autor: Badam, Tejaswi V., Hellberg, Sandra, Mehta, Ratnesh B., Lechner-Scott, Jeannette, Lea, Rodney A., Tost, Jorg, Mariette, Xavier, Svensson-Arvelund, Judit, Nestor, Colm E., Benson, Mikael, Berg, Göran, Jenmalm, Maria C., Gustafsson, Mika, Ernerudh, Jan

Publikováno v: Epigenetics; Sep2022, Vol. 17 Issue 9, p1040-1055, 16p

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CD4 ⁺ T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases.

Autor: Badam TV; Bioinformatics Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.; School of Bioscience, Skövde University, Skövde, Sweden., Hellberg S; Bioinformatics Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Mehta RB; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Lechner-Scott J; School of Medicine and Public Health, University of Newcastle, Callaghan, Australia.; Centre for Brain and Mental Health, Hunter Medical Research Institute, New Lambton Heights, Australia.; Department of Neurology, John Hunter Hospital, New Lambton Heights, Australia., Lea RA; School of Medicine and Public Health, University of Newcastle, Callaghan, Australia.; Centre for Brain and Mental Health, Hunter Medical Research Institute, New Lambton Heights, Australia.; Institute of Health and Biomedical Innovations, Genomics Research Centre, Queensland University of Technology, Kelvin Grove, Australia., Tost J; Laboratory of Epigenetics and Environment, Centre National De Recherche En Génomique Humaine, CEA-Institut De Biologie Francois Jacob, Evry, France., Mariette X; Université Paris-Saclay, AP-HP-Université Paris-Saclay, Hôpital Bicêtre, Institut National de la Santé et de la Recherche Médicale (Inserm) U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, France., Svensson-Arvelund J; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Nestor CE; The Centre for Individualized Medicine, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Benson M; The Centre for Individualized Medicine, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Berg G; Department of Obstetrics and Gynaecology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Jenmalm MC; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Gustafsson M; Bioinformatics Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden., Ernerudh J; Department of Clinical Immunology and Transfusion Medicine and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Publikováno v: Epigenetics [Epigenetics] 2022 Sep; Vol. 17 (9), pp. 1040-1055. Date of Electronic Publication: 2021 Oct 04.