Výsledky vyhledávání - "Baculoviridae/genetics"

Impact of Inverted Terminal Repeat Integrity on rAAV8 Production Using the Baculovirus/Sf9 Cells System

Autor: Otto-Wilhelm Merten, Lucile Nauwynck, Yohann Dickx, Lionel Galibert, Adrien Savy, Delphine Bonnin

Publikováno v: Human Gene Therapy Methods
Hum Gene Ther Methods
Hum Gene Ther Methods, 2017, 28 (5), pp.277-289. ⟨10.1089/hgtb.2016.133⟩

International audience; Adeno-associated virus (AAV) inverted terminal repeats (ITRs) are key elements of AAV. These guanine-cytosine-rich structures are involved in the replication and encapsidation of the AAV genome, along with its integration in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401339db4aad7de78be755e1e33f8aa7
https://doi.org/10.1089/hgtb.2016.133

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Production and crystallization of lobster muscle tropomyosin expressed in Sf9 cells

Autor: Soichi Wakatsuki, Yuichiro Maéda, Ken-Ichi Sano, Kayo Maeda, Kazuhiro Yamamoto, Andrea Miegel, Min Yao, Hisaaki Taniguchi

Publikováno v: FEBS Letters. 394:201-205

A new form of muscle tropomyosin crystal has been obtained, by employing new strategies in protein preparation and crystallization. Non-polymerizable tropomyosin was prepared by removing 11 amino acids at the C-terminus. The truncated tropomyosin was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c20c3c613e877051e3cc154d7596271
https://doi.org/10.1016/0014-5793(96)00949-0

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Latest developments in the large-scale production of adeno-associated virus vectors in insect cells toward the treatment of neuromuscular diseases

Autor: Otto-Wilhelm Merten, Lionel Galibert

Publikováno v: J Invertebr Pathol
J Invertebr Pathol, 2011, 107 Suppl, pp.S80-93. ⟨10.1016/j.jip.2011.05.008⟩

International audience; Adeno-associated viral (AAV) vectors are gene vectors of choice for the development of gene therapy treatments for many rare diseases affecting various tissues including retina, central nervous system, liver, and muscle. The A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30579a918030c88e174b841a80db9c8
https://hal.science/hal-02881132

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An initiative to manufacture and characterize baculovirus reference material

Autor: Yoshifumi Hashimoto, Marc G. Aucoin, Amine Kamen, Paula M. Alves, Mauro Mezzina, Otto-Wilhelm Merten, Yu-Chen Hu, Kari J. Airenne, Monique M. van Oers

Publikováno v: Journal of Invertebrate Pathology 107 (2011) Suppl.
J Invertebr Pathol
J Invertebr Pathol, 2011, 107 Suppl, pp.S113-7. ⟨10.1016/j.jip.2011.02.007⟩
Journal of Invertebrate Pathology, 107(Suppl.), S113-S117

International audience; This letter to the editor brings to the attention of researchers an initiative to develop a baculovirus reference material repository. To be successful this initiative needs the support of a broad panel of researchers working

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6322675b9f25ed5988727b856274e9
https://pubmed.ncbi.nlm.nih.gov/21784226

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Granzymes and cell death

Autor: Martinvalet, Denis, Thiery, Jerome, Chowdhury, Dipanjan

Publikováno v: Methods in Enzymology, Vol. 442 (2008) pp. 213-230

Granzymes are cell death-inducing serine proteases released from cytotoxic granules of cytotoxic T lymphocytes and natural killer cells during granule exocytosis in response to viral infection or against transformed cells marked for elimination. A cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0a3dbe437e6d9d6d48fb2c0d89e1017d
https://pubmed.ncbi.nlm.nih.gov/18662572

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Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells

Autor: Martensen, P M, Justesen, Just

Publikováno v: Martensen, P M & Justesen, J 2001, ' Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells ', BioTechniques, vol. 30, no. 4, pp. 782-4, 786, 788 passim .

The insect cell line BTI-TN-5B1-4 (High Five) is frequently used to express recombinant proteins in large amounts using the baculovirus expression system. However, extensive proteolytic degradation of recombinant proteins is often encountered. Furthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::062eb945433e560d921840594c10cabb
https://pure.au.dk/portal/da/publications/specific-inhibitors-prevent-proteolytic-degradation-of-recombinant-proteins-expressed-in-high-five-cells(a2155573-759c-4392-b0c7-678d56440402).html

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Studies on processing, particle formation, and immunogenicity of the HIV-1 gag gene product: a possible component of a HIV vaccine

Autor: Wagner, R., Fliessbach, H., Wanner, G., Motz, M., Niedrig, M., Deby, G., von Brunn, A., Wolf, Hans J.

Antigens in a particulate conformation were shown to be highly immunogenic in mammals. For this reason, the particle forming capacity of derivatives of the HIV-1 group specific core antigen p55 gag was assayed and compared dependent on various expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ed5e7b519b0202a507dd690ca85c73

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Inhibition of mouse mammary tumor virus-induced T cell responses in vivo by antibodies to an open reading frame protein

Autor: Leonardo Scarpellino, H R MacDonald, A N Shakhov, Werner Held, Hans Acha-Orbea

Publikováno v: Journal of Experimental Medicine, vol. 176, no. 6, pp. 1769-1772
The Journal of Experimental Medicine

Minor lymphocyte stimulating (Mls) antigens specifically stimulate T cell responses that are restricted to particular T cell receptor (TCR) beta chain variable domains. The Mls phenotype is genetically controlled by an open reading frame (orf) locate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afd2edbb8d73241006d9dcd9918a0e9
https://serval.unil.ch/resource/serval:BIB_35F3DCDA65DB.P001/REF.pdf

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