Výsledky vyhledávání - "Bacterial Toxins/metabolism/ pharmacology"

Aerolysin Induces G-protein Activation and Ca2+Release from Intracellular Stores in Human Granulocytes

Autor: Antoinette Monod, Karl-Heinz Krause, Marc Fivaz, F. G. van der Goot

Publikováno v: Journal of Biological Chemistry, Vol. 273, No 29 (1998) pp. 18122-18129

Aerolysin is a pore-forming toxin that plays a key role in the pathogenesis of Aeromonas hydrophila infections. In this study, we have analyzed the effect of aerolysin on human granulocytes (HL-60 cells). Proaerolysin could bind to these cells, was p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba74906dfea5d4d02b23b6da2fde8ed
https://doi.org/10.1074/jbc.273.29.18122

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Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival

Autor: Jürg Tschopp, Laurence Abrami, Laure Gurcel, F. Gisou van der Goot, Stephen E. Girardin

Publikováno v: Cell. 126:1135-1145

SummaryMany pathogenic organisms produce pore-forming toxins as virulence factors. Target cells however mount a response to such membrane damage. Here we show that toxin-induced membrane permeabilization leads to a decrease in cytoplasmic potassium,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd7ed334b99f2677c6df074027096b4
https://doi.org/10.1016/j.cell.2006.07.033

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