Redox Impact on Bacterial Macromolecule: A Promising Avenue for Discovery and Development of Novel Antibacterials

Autor: Jamiu Olaseni Aribisala, Saheed Sabiu

Publikováno v: Biomolecules, Vol 12, Iss 11, p 1545 (2022)

Antibiotic resistance in bacteria has remained a serious public health concern, resulting in substantial deaths and morbidity each year. Factors such as mutation and abuse of currently available antibiotics have contributed to the bulk of the menace.

Externí odkaz: https://doaj.org/article/46acc97cf3774c65b8756b69d6ed98d3

When to wake up? The optimal waking-up strategies for starvation-induced persistence

Autor: Namiko Mitarai, Yusuke Himeoka

Publikováno v: Himeoka, Y & Mitarai, N 2021, ' When to wake up? The optimal waking-up strategies for starvation-induced persistence ', PLoS Computational Biology, vol. 17, no. 2, 1008655 . https://doi.org/10.1371/journal.pcbi.1008655
PLoS Computational Biology, Vol 17, Iss 2, p e1008655 (2021)
bioRxiv
PLoS Computational Biology

Prolonged lag time can be induced by starvation contributing to the antibiotic tolerance of bacteria. We analyze the optimal lag time to survive and grow the iterative and stochastic application of antibiotics. A simple model shows that the optimal l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5579cf665d9fd11484a2e5d5986b96a
https://curis.ku.dk/portal/da/publications/when-to-wake-up-the-optimal-wakingup-strategies-for-starvationinduced-persistence(2268bd73-b776-426b-b621-6fb31363f373).html

Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state

Autor: Claudia Antoni, Dennis Quentin, Stefan Raunser, Christos Gatsogiannis, Alexander E. Lang, Klaus Aktories

Publikováno v: PLoS Pathogens, Vol 16, Iss 8, p e1008530 (2020)
PLoS Pathogens

Anthrax toxin is the major virulence factor secreted by Bacillus anthracis, causing high mortality in humans and other mammals. It consists of a membrane translocase, known as protective antigen (PA), that catalyzes the unfolding of its cytotoxic sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9533d3b6e1530b8108efd729d8fcf7c
https://doaj.org/article/a52dd63056ea47a8930898189a56eab0

A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain

Autor: Andrés F. Londoño, Nicole L. Mendell, Donald H. Bouyer, David H. Walker

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007054 (2019)

Background The species of the Rickettsia genus are separated into four groups: the ancestral group, typhus group, transitional group and spotted fever group. Rickettsia parkeri, a spotted fever group Rickettsia, has been reported across the American

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6d1d6e3b6393321b14805d46e4391d
http://europepmc.org/articles/PMC6602283

Cecropin-like antimicrobial peptide protects mice from lethal E.coli infection

Autor: Steven Fiering, Anishma Shrestha, James A. Jukosky, Deepesh Duwadi

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0220344 (2019)
PLoS ONE

Resistance of pathogenic bacteria to standard antibiotics is an issue of great concern, and new treatments for bacterial infections are needed. Antimicrobial peptides (AMPs) are small, cationic, and amphipathic molecules expressed by metazoans that k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a6e9d0625ddece5cbf3beb567b8cfd
https://doaj.org/article/d0b26f09e1f0495babc2c7abf8ef2187