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Akademický článek

Mitohormesis during advanced stages of Duchenne muscular dystrophy reveals a redox-sensitive creatine pathway that can be enhanced by the mitochondrial-targeting peptide SBT-20

Autor: Meghan C. Hughes, Sofhia V. Ramos, Aditya N. Brahmbhatt, Patrick C. Turnbull, Nazari N. Polidovitch, Madison C. Garibotti, Uwe Schlattner, Thomas J. Hawke, Jeremy A. Simpson, Peter H. Backx, Christopher GR. Perry

Publikováno v: Redox Biology, Vol 76, Iss , Pp 103319- (2024)

Mitochondrial creatine kinase (mtCK) regulates the “fast” export of phosphocreatine to support cytoplasmic phosphorylation of ADP to ATP which is more rapid than direct ATP export. Such “creatine-dependent” phosphate shuttling is attenuated i

Externí odkaz: https://doaj.org/article/a74cffb251704d729df4c25f1d7a8846

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Akademický článek

Generating normative data from web-based administration of the Cambridge Neuropsychological Test Automated Battery using a Bayesian framework

Autor: Elizabeth Wragg, Caroline Skirrow, Pasquale Dente, Jack Cotter, Peter Annas, Milly Lowther, Rosa Backx, Jenny Barnett, Fiona Cree, Jasmin Kroll, Francesca Cormack

Publikováno v: Frontiers in Digital Health, Vol 6 (2024)

IntroductionNormative cognitive data can distinguish impairment from healthy cognitive function and pathological decline from normal ageing. Traditional methods for deriving normative data typically require extremely large samples of healthy particip

Externí odkaz: https://doaj.org/article/533ca7e372c749078f1428e70c9c7140

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Akademický článek

Nanotechnology for the control of plant pathogens and pests

Autor: Otávio Augusto L. dos Santos, Mayara Santana dos Santos, Sérgio Antunes Filho, Bianca Pizzorno Backx

Publikováno v: Plant Nano Biology, Vol 8, Iss , Pp 100080- (2024)

Agriculture is the primary food source and fundamental for human survival. However, managing pests and diseases of crops remains a challenge. Moreover, climate change events such as drought, soil depletion, and low nutrient use efficiency are signifi

Externí odkaz: https://doaj.org/article/cd1585f2a7364ba19b9da04fb7684376

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Akademický článek

Bionanotechnology and its applications: The plurality of science is fundamental for the search for solutions

Autor: Mayara Santana dos Santos, Jonathan Medeiros Silva, Mariana Brito Barbieri, Sérgio Antunes Filho, Bianca Pizzorno Backx

Publikováno v: Plant Nano Biology, Vol 7, Iss , Pp 100060- (2024)

Over the years, science and technology have enabled improvement in various sectors of society through the development of products, services, and applications. Despite the tremendous scientific development, it is necessary to understand and pay attent

Externí odkaz: https://doaj.org/article/5db54581ebd8474894a28ca949680399

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Akademický článek

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Akademický článek

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Akademický článek

Educação 4.0 e Docência em Cursos de Gestão: O que Podemos Aprender com o Designer Educacional?

Autor: Vanessa Itacaramby Pardim, Andrea Consolino Ximenes, Iara Yamamoto, Felipe Carvalhal Barbosa, Adriana Backx Noronha Viana

Publikováno v: Administração: Ensino e Pesquisa, Vol 24, Iss 2 (2023)

Pensar o processo de ensino e aprendizagem no contexto da Educação 4.0 é um desafio, dada a presença crescente das tecnologias digitais de informação e comunicação (TDICs) nas salas de aula. A questão é que, muitas vezes, os professores se

Externí odkaz: https://doaj.org/article/ab0a9c3fa2464c83b3e248d6af6e9ce4

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Akademický článek

Apelin receptor inhibition in ischemia-reperfused mouse hearts protected by endogenous n-3 polyunsaturated fatty acids

Autor: Shuang Zheng, Weijiang Tan, Xiang Li, Lijing Wang, Caiyi Zhu, W. Glen Pyle, Jianxin Chen, Jian Wu, Xuecong Ren, Honghua Chen, Yunzeng Zou, Peter H. Backx, Feng Hua Yang

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Background: While the protective effects of n-3 polyunsaturated fatty acids (PUFAs) on cardiac ischemia-reperfusion (IR) injury have been previously reported, limited data are available regarding how these fatty acids affect membrane receptors and th

Externí odkaz: https://doaj.org/article/2ee3dbf4f3ac48d49e42d5c5ad7ce9ee

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Akademický článek

Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrop

Externí odkaz: https://doaj.org/article/aafde2c6ca28412ea8f19a14b47c1f34

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