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Akademický článek

Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells.

Autor: Giovannetti E; Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands., Backus HH, Wouters D, Peters GJ

Publikováno v: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2008 Jun; Vol. 27 (6), pp. 740-5.

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Akademický článek

Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.

Autor: Giovannetti E; Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands., Backus HH, Wouters D, Ferreira CG, van Houten VM, Brakenhoff RH, Poupon MF, Azzarello A, Pinedo HM, Peters GJ

Publikováno v: British journal of cancer [Br J Cancer] 2007 Mar 12; Vol. 96 (5), pp. 769-75.

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Akademický článek

Affinity ranking of antibodies using flow cytometry: application in antibody phage display-based target discovery.

Autor: Geuijen CA; Crucell Holland B.V., P.O. Box 2048, Leiden 2301 CA, The Netherlands., Clijsters-van der Horst M, Cox F, Rood PM, Throsby M, Jongeneelen MA, Backus HH, van Deventer E, Kruisbeek AM, Goudsmit J, de Kruif J

Publikováno v: Journal of immunological methods [J Immunol Methods] 2005 Jul; Vol. 302 (1-2), pp. 68-77.

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Akademický článek

The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries.

Autor: Kramer RA; Crucell Holland B.V., Leiden, The Netherlands., Marissen WE, Goudsmit J, Visser TJ, Clijsters-Van der Horst M, Bakker AQ, de Jong M, Jongeneelen M, Thijsse S, Backus HH, Rice AB, Weldon WC, Rupprecht CE, Dietzschold B, Bakker AB, de Kruif J

Publikováno v: European journal of immunology [Eur J Immunol] 2005 Jul; Vol. 35 (7), pp. 2131-45.

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Akademický článek

Novel human monoclonal antibody combination effectively neutralizing natural rabies virus variants and individual in vitro escape mutants.

Autor: Bakker AB; Crucell Holland B.V., Archimedesweg 4, P.O. Box 2048, 2301 CA Leiden, The Netherlands., Marissen WE, Kramer RA, Rice AB, Weldon WC, Niezgoda M, Hanlon CA, Thijsse S, Backus HH, de Kruif J, Dietzschold B, Rupprecht CE, Goudsmit J

Publikováno v: Journal of virology [J Virol] 2005 Jul; Vol. 79 (14), pp. 9062-8.

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Akademický článek

Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.

Autor: Sigmond J; Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands., Backus HH, Wouters D, Temmink OH, Jansen G, Peters GJ

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2003 Aug 01; Vol. 66 (3), pp. 431-8.

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Akademický článek

Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.

Autor: Backus HH; Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. gj.peters@vumc.nl, Wouters D, Ferreira CG, van Houten VM, Brakenhoff RH, Pinedo HM, Peters GJ

Publikováno v: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2003 Jun; Vol. 39 (9), pp. 1310-7.

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Akademický článek

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.

Autor: Peters GJ; Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands. gj.peters@vumc.nl, Backus HH, Freemantle S, van Triest B, Codacci-Pisanelli G, van der Wilt CL, Smid K, Lunec J, Calvert AH, Marsh S, McLeod HL, Bloemena E, Meijer S, Jansen G, van Groeningen CJ, Pinedo HM

Publikováno v: Biochimica et biophysica acta [Biochim Biophys Acta] 2002 Jul 18; Vol. 1587 (2-3), pp. 194-205.

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Akademický článek

Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases.

Autor: Backus HH; Department of Medical Oncology, VU University Medical Center, PO Box 7057, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands., Van Groeningen CJ, Vos W, Dukers DF, Bloemena E, Wouters D, Pinedo HM, Peters GJ

Publikováno v: Journal of clinical pathology [J Clin Pathol] 2002 Mar; Vol. 55 (3), pp. 206-11.

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Akademický článek

Chemotherapeutic strategies for treatment of colorectal cancer: present and future developments.

Autor: Backus HH; Department of Medical Oncology, Vrije Universiteit Medical Center, Universiteit, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Rustum YM, van Groeningen CJ, Peters GJ

Publikováno v: Clinical colorectal cancer [Clin Colorectal Cancer] 2001 Aug; Vol. 1 (2), pp. 121-7.

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