Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.

Autor: Backman, JD¹, Yerges‐Armstrong, LM¹, Horenstein, RB¹, Newcomer, S¹, Shaub, S¹, Morrisey, M¹, Donnelly, P¹, Drolet, M¹, Tanner, K¹, Pavlovich, MA¹, O'Connell, JR¹, Mitchell, BD^1,2, Lewis, JP¹ jlewis2@medicine.umaryland.edu

Publikováno v: CTS: Clinical & Translational Science. Mar2017, Vol. 10 Issue 2, p102-109. 8p.

Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.

Autor: Levin MG; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Tsao NL; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Singhal P; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Liu C; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Vy HMT; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Paranjpe I; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Backman JD; Regeneron Genetics Center, Tarrytown, NY, USA., Bellomo TR; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bone WP; Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Biddinger KJ; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Hui Q; Emory University School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Dikilitas O; Departments of Internal Medicine and Cardiovascular Medicine, and Mayo Clinician-Investigator Training Program, Mayo Clinic, Rochester, MN, USA., Satterfield BA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Yang Y; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Morley MP; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bradford Y; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Burke M; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Reza N; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Charest B; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA, USA., Judy RL; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Puckelwartz MJ; Department of Pharmacology, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Hakonarson H; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Khan A; Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Kottyan LC; Department of Pediatrics, Division of Human Genetics and Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Kullo I; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Luo Y; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., McNally EM; Center for Genetic Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Day SM; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Do R; The Charles Bronfman Institute for Personalized Medicine, BioMe Phenomics Center, and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Phillips LS; Atlanta VA Health Care System, Decatur, GA, USA.; Division of Endocrinology, Emory University School of Medicine, Atlanta, GA, USA., Ellinor PT; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA., Nadkarni GN; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ritchie MD; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Arany Z; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cappola TP; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Margulies KB; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Aragam KG; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Haggerty CM; Department of Translational Data Science and Informatics and Heart Institute, Geisinger, Danville, PA, USA., Joseph J; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sun YV; Emory University School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Voight BF; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute of Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Damrauer SM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. damrauer@upenn.edu.; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. damrauer@upenn.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 14; Vol. 13 (1), pp. 6914. Date of Electronic Publication: 2022 Nov 14.

The genomics of heart failure: design and rationale of the HERMES consortium.

Autor: Lumbers RT; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; BHF Research Accelerator, University College London, London, UK., Shah S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Institute of Cardiovascular Science, University College London, London, UK., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA., Czuba T; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden., Henry A; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Institute of Cardiovascular Science, University College London, London, UK., Swerdlow DI; Institute of Cardiovascular Science, University College London, London, UK.; Department of Medicine, Imperial College London, London, UK., Mälarstig A; Pfizer Worldwide Research & Development, Cambridge, MA, USA.; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden., Andersson C; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Holmes MV; Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK., Ärnlöv J; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.; School of Health and Social Sciences, Dalarna University, Falun, Sweden., Svensson P; Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.; Department of Cardiology, Södersjukhuset, Stockholm, Sweden., Hemingway H; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK., Sallah N; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; UCL Genetics Institute, University College London, London, UK., Almgren P; Department of Clinical Sciences, Lund University, Malmö, Sweden., Aragam KG; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Asselin G; Montreal Heart Institute, Montreal, Quebec, Canada., Backman JD; Regeneron Genetics Center, Tarrytown, NY, USA., Biggs ML; Department of Biostatistics, University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA., Bloom HL; Division of Cardiology, Department of Medicine, Emory University Medical Center, Atlanta, GA, USA., Boersma E; Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Brandimarto J; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Brunner-La Rocca HP; Maastricht University Medical Center, Maastricht, The Netherlands., Carey DJ; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Chaffin MD; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chazara O; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Chen X; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Chen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Chung JH; Regeneron Genetics Center, Tarrytown, NY, USA., Chutkow W; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Cleland JGF; Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.; National Heart and Lung Institute, Imperial College, London, UK., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool, UK., de Denus S; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada., Dehghan A; Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.; MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK., Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany., Denaxas S; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK.; The Alan Turing Institute, British Library, London, UK., Doney AS; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Dudley SC; Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Engström G; Department of Clinical Sciences, Lund University, Malmö, Sweden., Esko T; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Fatemifar G; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK., Felix SB; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Finan C; Institute of Cardiovascular Science, University College London, London, UK., Ford I; Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK., Fougerousse F; Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France., Fouodjio R; Montreal Heart Institute, Montreal, Quebec, Canada., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Ghasemi S; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gottdiener JS; Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA., Gross S; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Guðbjartsson DF; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Gui H; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA., Gutmann R; Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Haggerty CM; Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands., Hedman ÅK; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden., Helgadottir A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Hillege H; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Hyde CL; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Jacob J; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Kamanu F; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kardys I; Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Kavousi M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany., Køber L; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Koekemoer A; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kraus B; Duke Molecular Physiology Institute, Durham, NC, USA., Kuchenbaecker K; UCL Genetics Institute, University College London, London, UK.; Division of Psychiatry, University College of London, London, UK., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Lindgren CM; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., London B; Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA., Lotta LA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Lovering RC; Institute of Cardiovascular Science, University College London, London, UK., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Magnusson P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Mahajan A; Genentech Inc., San Francisco, CA, USA., Mann D; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Margulies KB; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Marston NA; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., McMurray JJV; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK., Melander O; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden., Melloni G; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Mordi IR; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Morley MP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Morris AD; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Morris AP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Nagle MW; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Nelson CP; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Newton-Cheh C; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA., Niessner A; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Niiranen T; Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland., Nowak C; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden., O'Donoghue ML; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Owens AT; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Palmer CNA; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Paré G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Perola M; National Institute for Health and Welfare, Helsinki, Finland., Perreault LL; Montreal Heart Institute, Montreal, Quebec, Canada., Portilla-Fernandez E; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Romaine SPR; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Roselli C; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Ruff CT; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sabatine MS; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Salo P; Finnish Institute for Health and Welfare, Helsinki, Finland., Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland., van Setten J; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Shalaby AA; Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA., Smelser DT; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Smith NL; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland., Stender S; Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte, Denmark., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Sveinbjörnsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Tammesoo ML; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Tardif JC; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Teumer A; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thorgeirsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland., Torp-Pedersen C; Department of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.; Department of Health, Science and Technology, Aalborg University Hospital, Aalborg, Denmark.; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands., Tuckwell D; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Tyl B; Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Vaura F; Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Clinical Medicine, University of Turku, Turku, Finland., Veluchamy A; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Völker U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Voors AA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Wang X; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Weeke PE; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Weiss R; Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA., White HD; Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand., Wiggins KL; Department of Medicine, University of Washington, Seattle, WA, USA., Xing H; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Yang Y; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Yerges-Armstrong LM; Human Genetics, GlaxoSmithKline, Collegeville, PA, USA., Yu B; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Zannad F; CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, Université de Lorraine, Nancy, France., Zhao F; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Wilk JB; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Sattar N; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK., Lubitz SA; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Lanfear DE; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.; Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA., Shah S; Duke Molecular Physiology Institute, Durham, NC, USA.; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Duke Clinical Research Institute, Durham, NC, USA., Dunn ME; Regeneron Pharmaceuticals, Cardiovascular Research, Tarrytown, NY, USA., Wells QS; Division of Cardiovascular Medicine and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN, USA., Asselbergs FW; Health Data Research UK London, University College London, London, UK.; BHF Research Accelerator, University College London, London, UK.; Institute of Cardiovascular Science, University College London, London, UK.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Hingorani AD; BHF Research Accelerator, University College London, London, UK.; Institute of Cardiovascular Science, University College London, London, UK., Dubé MP; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Samani NJ; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Lang CC; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Cappola TP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ellinor PT; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Vasan RS; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA., Smith JG; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Publikováno v: ESC heart failure [ESC Heart Fail] 2021 Dec; Vol. 8 (6), pp. 5531-5541. Date of Electronic Publication: 2021 Sep 03.

Genome-wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals.

Autor: Gao C; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Marcketta A; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Backman JD; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., O'Dushlaine C; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Staples J; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Ferreira MAR; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Lotta LA; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Overton JD; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Reid JG; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Mirshahi T; Molecular and Functional Genomics, Geisinger Clinic, Danville, Pennsylvania, USA., Regeneron Genetics Center; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Geisinger Regeneron Discovehr Collaboration, Baras A; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Abecasis G; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Shuldiner AR; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., Van Hout CV; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA., McCarthy S; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, USA.

Publikováno v: Genetic epidemiology [Genet Epidemiol] 2021 Sep; Vol. 45 (6), pp. 664-681. Date of Electronic Publication: 2021 Jun 29.

Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease.

Autor: Horowitz JE; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Kosmicki JA; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Damask A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Sharma D; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Roberts GHL; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Justice AE; Geisinger, Danville, PA, 17822, USA., Banerjee N; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Coignet MV; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Yadav A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Leader JB; Geisinger, Danville, PA, 17822, USA., Marcketta A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Park DS; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Lanche R; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Maxwell E; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Knight SC; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Bai X; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Guturu H; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Sun D; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Baltzell A; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Kury FSP; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Backman JD; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Girshick AR; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., O'Dushlaine C; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., McCurdy SR; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Partha R; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Mansfield AJ; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Turissini DA; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Li AH; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Zhang M; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Mbatchou J; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Watanabe K; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Gurski L; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., McCarthy SE; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Kang HM; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Dobbyn L; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Stahl E; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Sirugo G; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Ritchie MD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Jones M; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Balasubramanian S; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Siminovitch K; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Salerno WJ; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Shuldiner AR; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Mirshahi T; Geisinger, Danville, PA, 17822, USA., Locke AE; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Marchini J; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Overton JD; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Carey DJ; Geisinger, Danville, PA, 17822, USA., Habegger L; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Cantor MN; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Rand KA; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Hong EL; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Reid JG; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Ball CA; AncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA., Baras A; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Abecasis GR; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA., Ferreira MA; Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2021 Jun 10. Date of Electronic Publication: 2021 Jun 10.