Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Bachisio Ziccheddu"'
Autor:
Bachisio Ziccheddu, Claudia Giannotta, Mattia D’Agostino, Giuseppe Bertuglia, Elona Saraci, Stefania Oliva, Elisa Genuardi, Marios Papadimitriou, Benjamin Diamond, Paolo Corradini, David Coffey, Ola Landgren, Niccolò Bolli, Benedetto Bruno, Mario Boccadoro, Massimo Massaia, Francesco Maura, Alessandra Larocca
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Targeted immunotherapy combinations, including the anti-CD38 monoclonal antibody (MoAb) daratumumab, have shown promising results in patients with relapsed/refractory multiple myeloma (RRMM), leading to a considerable increase in progression
Externí odkaz:
https://doaj.org/article/a0836646950848c8a7696721b96ea559
Autor:
Francesco Maura, David G. Coffey, Caleb K. Stein, Esteban Braggio, Bachisio Ziccheddu, Meaghen E. Sharik, Megan T. Du, Yuliza Tafoya Alvarado, Chang-Xin Shi, Yuan Xiao Zhu, Erin W. Meermeier, Gareth J. Morgan, Ola Landgren, P. Leif Bergsagel, Marta Chesi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Multiple myeloma (MM) is a heterogeneous disease characterized by frequent MYC translocations. Sporadic MYC activation in the germinal center of genetically engineered Vk*MYC mice is sufficient to induce plasma cell tumors in which a variety
Externí odkaz:
https://doaj.org/article/0fb36d4f85d4436b947de3da11cd1f2d
Autor:
Kylee H. Maclachlan, Even H. Rustad, Andriy Derkach, Binbin Zheng-Lin, Venkata Yellapantula, Benjamin Diamond, Malin Hultcrantz, Bachisio Ziccheddu, Eileen M. Boyle, Patrick Blaney, Niccolò Bolli, Yanming Zhang, Ahmet Dogan, Alexander M. Lesokhin, Gareth J. Morgan, Ola Landgren, Francesco Maura
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Chromothripsis is associated with unfavourable outcomes in multiple myeloma (MM), but its detection usually requires whole genome sequencing. Here the authors develop an approach to detect chromothripsis in MM based on copy-number signatures that als
Externí odkaz:
https://doaj.org/article/b5e6a8716f6d4f72afb2988be3482362
Autor:
Even H. Rustad, Ferran Nadeu, Nicos Angelopoulos, Bachisio Ziccheddu, Niccolò Bolli, Xose S. Puente, Elias Campo, Ola Landgren, Francesco Maura
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Rustad et al. present a software package for the R statistical environment for the accurately quantify of somatic mutational signatures in hematological malignancies
Externí odkaz:
https://doaj.org/article/1798eaafba7b4603af2c13853c09ffc6
Autor:
Even H. Rustad, Venkata Yellapantula, Daniel Leongamornlert, Niccolò Bolli, Guy Ledergor, Ferran Nadeu, Nicos Angelopoulos, Kevin J. Dawson, Thomas J. Mitchell, Robert J. Osborne, Bachisio Ziccheddu, Cristiana Carniti, Vittorio Montefusco, Paolo Corradini, Kenneth C. Anderson, Philippe Moreau, Elli Papaemmanuil, Ludmil B. Alexandrov, Xose S. Puente, Elias Campo, Reiner Siebert, Herve Avet-Loiseau, Ola Landgren, Nikhil Munshi, Peter J. Campbell, Francesco Maura
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The initial mutational processes and how these lead to progression in multiple myeloma (MM) are unclear. Here, the authors identify mutational signatures that occur over time in a large cohort of MM patients and suggest features that may help in earl
Externí odkaz:
https://doaj.org/article/5bcecbd98cdc4f9fbf76239987880049
Autor:
Francesco Maura, Andrea Degasperi, Ferran Nadeu, Daniel Leongamornlert, Helen Davies, Luiza Moore, Romina Royo, Bachisio Ziccheddu, Xose S. Puente, Herve Avet-Loiseau, Peter J. Campbell, Serena Nik-Zainal, Elias Campo, Nikhil Munshi, Niccolò Bolli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Mutational signature analysis provides important information about the mutational processes underpinning different stages of tumorigenesis. Here, the authors compare publicly available signature extraction tools and suggest a framework for the genera
Externí odkaz:
https://doaj.org/article/db472ad80eb543dd8f9c840674ea9d19
Autor:
Matteo C. Da Vià, Bachisio Ziccheddu, Akihiro Maeda, Filippo Bagnoli, Giulia Perrone, Niccolò Bolli
Publikováno v:
HemaSphere, Vol 4, Iss 6, p e502 (2020)
Abstract. The knowledge of cancer origin and the subsequent tracking of disease evolution represent unmet needs that will soon be within clinical reach. This will provide the opportunity to improve patient's stratification and to personalize treatmen
Externí odkaz:
https://doaj.org/article/17a6dd0a5aed464b87896560ed433e31
Autor:
Martina Manzoni, Alessandra Pompa, Sonia Fabris, Francesca Pelizzoni, Gabriella Ciceri, Manuela Seia, Bachisio Ziccheddu, Niccolò Bolli, Paolo Corradini, Luca Baldini, Antonino Neri, Marta Lionetti
Publikováno v:
HemaSphere, Vol 4, Iss 4, p e402 (2020)
Externí odkaz:
https://doaj.org/article/dbd1fd2e8d644703aff22832a1db2212
Autor:
Niccolo Bolli, Elisa Genuardi, Bachisio Ziccheddu, Marina Martello, Stefania Oliva, Carolina Terragna
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Personalized treatment is an attractive strategy that promises increased efficacy with reduced side effects in cancer. The feasibility of such an approach has been greatly boosted by next-generation sequencing (NGS) techniques, which can return detai
Externí odkaz:
https://doaj.org/article/a0b07b7700bf49d28f77299e78d39309
Autor:
Martina Manzoni, Valentina Marchica, Paola Storti, Bachisio Ziccheddu, Gabriella Sammarelli, Giannalisa Todaro, Francesca Pelizzoni, Simone Salerio, Laura Notarfranchi, Alessandra Pompa, Luca Baldini, Niccolò Bolli, Antonino Neri, Nicola Giuliani, Marta Lionetti
Publikováno v:
Cancers, Vol 12, Iss 5, p 1332 (2020)
Genomic analysis could contribute to a better understanding of the biological determinants of the evolution of multiple myeloma (MM) precursor disease and an improved definition of high-risk patients. To assess the feasibility and value of next-gener
Externí odkaz:
https://doaj.org/article/9ddd1dfe44b449aa931a918d1f13b6a4