Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Bachir, Latli"'
Autor:
Bachir Latli, Matt J. Hrapchak, Lalith P. Samankumara, Daniel R. Fandrick, Scott Pennino, Heewon Lee, Jinhua J. Song
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 66:155-168
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 66:145-154
Autor:
Valerie Kvaternick, Scott Pennino, Amy Gao, Berhane Tecle, Bachir Latli, Jeff J. Song, Nathan K. Yee
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 63:386-392
Firocoxib (ML-1,785,713) is a nonsteroidal, potent, and selective COX-2 inhibitor, approved for the control of pain and inflammation associated with osteoarthritis in dogs and horses, as well as to control postoperative pain and inflammation in dogs.
Publikováno v:
Organic Syntheses. :374-402
Autor:
Maxim Cheveliakov, Matt Hrapchak, Carl A. Busacca, Jonathan T. Reeves, Bachir Latli, Chris H. Senanayake, Maurice A. Marsini
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 61:764-772
1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide (1) and its analogs (2) and (3) are potent CCR1 antagonists intended for the treatment of rheumatoid arthritis. The detailed syntheses of the
Autor:
Heewon Lee, Zhibin Li, Carl A. Busacca, Nelu Grinberg, Michael Dipl Chem Dr Stiasni, Chris H. Senanayake, Bachir Latli, Matt Hrapchak
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:557-564
Hyosine butyl bromide, the active ingredient in Buscopan, is an anticholinergic and antimuscarinic drug used to treat pain and discomfort caused by abdominal cramps. A straightforward synthesis of carbon-14– and deuterium-labeled Buscopan was devel
Autor:
Ralf Kiesling, Stefan Aßfalg, Chris H. Senanayake, Nina C. Gonnella, Max Chevliakov, Matt Hrapchak, Bachir Latli, Carl A. Busacca, Scot Campbell
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:648-656
Dabigatran etexilate or pradaxa, a novel oral anticoagulant, is a reversible, competitive, direct thrombin inhibitor. It is used to prevent strokes in patients with atrial fibrillation and the formation of blood clots in the veins (deep venous thromb
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:300-304
3-Amino-4-(1,1-difluoro-propyl)-6-(4-methanesulfonyl-piperidin-1-yl)-thieno[2,3-b]pyridine-2-carboxylic acid amide (1) is a potent IκB Kinase-β (IKK-β) inhibitor. The efficient preparations of this compound labeled with carbon-14 and deuterium are
Autor:
Josh Horan, Matt Hrapchak, Jon C. Lorenz, Carl A. Busacca, Bachir Latli, Guisheng Li, Chris H. Senanayake
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals. 62(2)
The drug candidates (2) and (3) are highly potent LFA-1 inhibitors. They were efficiently prepared labeled with carbon-14 using a palladium-catalyzed carboxylation of an iodo-precursor (5) and sodium formate-14 C to afford acid [14 C]-(6), which was
Autor:
Carl B. Busacca, Zhulin Tan, Bachir Latli, Jinhua J. Song, Matt Hrapchak, Jonathan T. Reeves, Chris H. Senanayake
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:445-452
Two potent glucocorticoid receptor agonists were prepared labeled with carbon-14 and with stable isotopes to perform drug metabolism, pharmacokinetics, and bioanalytical studies. Carbon-14 labeled (1) was obtained from an enantiopure alkyne (5) via a