Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway

Autor: Sitao Zhang, Yongchang Xu, Hongxin Guan, Tao Cui, Yuling Liao, Wenhui Wei, Jun Li, Bachar H. Hassan, Huimin Zhang, Xu Jia, Songying Ouyang, Youjun Feng

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Biotin is an essential enzyme cofactor and two pathways for the generation of the biotin precursor pimeloyl-ACP are known. Here, the authors identify and characterize a third pathway for biotin precursor synthesis involving BioZ and they also present

Externí odkaz: https://doaj.org/article/c80e552cb1354f92b240e8c666740d25

Characterization of the Bifunctional Enzyme BioDA Involved in Biotin Synthesis and Pathogenicity in Aspergillus flavus

Autor: Bachar H. Hassan, Wenhui Wei, Faxiu Lan, Yinghang Liu, Lianghuan Wu, Shihua Wang

Publikováno v: Journal of Agricultural and Food Chemistry. 69:11971-11981

Biotin is an important enzyme cofactor that plays a key role in all three domains. The classical bifunctional enzyme BioDA in eukaryotes (such as Aspergillus flavus and Arabidopsis thaliana) is involved in the antepenultimate and penultimate steps of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30776cd8f423983d1716bc36dbffd425
https://doi.org/10.1021/acs.jafc.1c03248

Characterization of the Bifunctional Enzyme BioDA Involved in Biotin Synthesis and Pathogenicity in

Autor: Wenhui, Wei, Faxiu, Lan, Yinghang, Liu, Lianghuan, Wu, Bachar H, Hassan, Shihua, Wang

Publikováno v: Journal of agricultural and food chemistry. 69(40)

Biotin is an important enzyme cofactor that plays a key role in all three domains. The classical bifunctional enzyme BioDA in eukaryotes (such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f2553a374a77237fb193e4e876511be
https://pubmed.ncbi.nlm.nih.gov/34591470

Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism

Autor: Bachar H. Hassan, Steven Vestergaard Rødkær, Baasil Shariff, Yusuf A. Hannun, Ashraf A. Shamssedine, W. Jim Zheng, Justin Snider, Eun-Mi Jeong, Bidyut K. Mohanty, Nabil Matmati, Nils J. Færgeman, Lina M. Obeid, Guocai Chen, Martin Røssel-Larsen, Jihui Ren

Publikováno v: Matmati, N, Hassan, B H, Ren, J, Shamssedine, A A, Jeong, E, Shariff, B, Snider, J, Rødkær, S V, Chen, G, Mohanty, B K, Zheng, W J, Obeid, L M, Røssel-Larsen, M, Færgeman, N J & Hannun, Y A 2020, ' Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism ', Molecular and Cellular Biology, vol. 40, no. 12, e00340-19 . https://doi.org/10.1128/MCB.00340-19

Defects in the spindle assembly checkpoint (SAC) can lead to aneuploidy and cancer. Sphingolipids have important roles in many cellular functions, including cell cycle regulation and apoptosis. However, the specific mechanisms and functions of sphing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d11994cb137b6054010b72dfcea412a
https://findresearcher.sdu.dk:8443/ws/files/170551897/Molecular_and_Cellular_Biology_2020_Matmati_MCB.00340_19.full.pdf

A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

Autor: Bachar H. Hassan, Youjun Feng, Jiao-Yu Deng, Jun Li, Rongsui Gao, Wenhui Wei

Publikováno v: eLife, Vol 8 (2019)
eLife

Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all domains of life, and its homeostasis must be regulated tightly. Here we report that a Nudix-related transcriptional factor, designated MsNrtR (MSMEG_3198), controls the de n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce0d865fff9fa31f4d2911ade698c76
https://elifesciences.org/articles/51603