Therapeutic approaches targeting seizure networks.

Autor: Langbein J; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States., Boddeti U; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States.; Surgical Neurology Branch, National Institute of Neurological Disorders, National Institutes of Health, Bethesda, MD, United States., Kreinbrink M; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States., Khan Z; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States., Rampalli I; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, United States., Bachani M; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States., Ksendzovsky A; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States.

Publikováno v: Frontiers in network physiology [Front Netw Physiol] 2024 Aug 07; Vol. 4, pp. 1441983. Date of Electronic Publication: 2024 Aug 07 (Print Publication: 2024).

TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression.

Autor: Garcia-Montojo M; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Fathi S; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Rastegar C; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Simula ER; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA.; Struttura Complessa Microbiologia e Virologia, Azienda Ospedaliera Universitaria Sassari, Sassari, Italy., Doucet-O'Hare T; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Cheng YHH; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Abrams RPM; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Pasternack N; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Malik N; Translational Neuroscience Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Bachani M; Translational Neuroscience Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Disanza B; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Maric D; Flow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Lee MH; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Wang H; Neuro-Oncology Branch, National Cancer Institute (NIH), Bethesda, MD, USA., Santamaria U; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Li W; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Sampson K; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Lorenzo JR; Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET-CICPBA-UNCPBA, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro (FCV-UNCPBA), Tandil, Argentina., Sanchez IE; Protein Physiology Laboratory, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales and IQUIBICEN-CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina., Mezghrani A; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA.; Centre de Biologie Structurale, Centre national de la recherche scientifique (CNRS), Montpellier, France., Li Y; Protein/Peptide Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Sechi LA; Struttura Complessa Microbiologia e Virologia, Azienda Ospedaliera Universitaria Sassari, Sassari, Italy., Pineda S; Massachusetts Institute of Technology, Cambridge, MA, USA., Heiman M; Massachusetts Institute of Technology, Cambridge, MA, USA., Kellis M; Massachusetts Institute of Technology, Cambridge, MA, USA., Steiner J; Translational Neuroscience Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA., Nath A; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA. natha@ninds.nih.gov.

Publikováno v: Nature communications [Nat Commun] 2024 May 16; Vol. 15 (1), pp. 4163. Date of Electronic Publication: 2024 May 16.

Neurotoxic properties of the Zika virus envelope protein.

Autor: Steiner JP; Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America., Bachani M; Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America., Malik N; Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America., Li W; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America., Tyagi R; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America., Sampson K; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America., Abrams RPM; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America., Kousa Y; Division of Neurology, Children's National Hospital, Washington, DC 20010, USA; Department of Genomics and Precision Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, USA., Solis J; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America., Johnson TP; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America., Nath A; Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America; Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States of America. Electronic address: natha@ninds.nih.gov.

Publikováno v: Experimental neurology [Exp Neurol] 2023 Sep; Vol. 367, pp. 114469. Date of Electronic Publication: 2023 Jun 14.

Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway.

Autor: Ksendzovsky A; Department of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.; Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.; Department of Neurological Surgery, University of Virginia Health System, University of Virginia, Charlottesville, VA 22903, USA., Bachani M; Drug Development Unit, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA., Altshuler M; Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA., Walbridge S; Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA., Mortazavi A; Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA., Moyer M; Department of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA., Chen C; Department of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA., Fayed I; Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA., Steiner J; Department of Neurological Surgery, University of Virginia Health System, University of Virginia, Charlottesville, VA 22903, USA., Edwards N; Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA., Inati SK; Office of the Clinical Director, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA., Jahanipour J; Flow and Cytometry Core, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda MD, 20892, USA., Maric D; Flow and Cytometry Core, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda MD, 20892, USA., Heiss JD; Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA., Kapur J; Department of Neurology, University of Virginia Health System, University of Virginia, Charlottesville, VA 22903, USA.; Neuroscience Department, University of Virginia Health System, University of Virginia, Charlottesville, VA 22903, USA., Zaghloul KA; Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.

Publikováno v: Brain communications [Brain Commun] 2022 Dec 01; Vol. 5 (1), pp. fcac298. Date of Electronic Publication: 2022 Dec 01 (Print Publication: 2023).

Human Endogenous Retrovirus K Envelope in Spinal Fluid of Amyotrophic Lateral Sclerosis Is Toxic.

Autor: Steiner JP; NeuroTherapeutics Development Unit, Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Bachani M; NeuroTherapeutics Development Unit, Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Malik N; NeuroTherapeutics Development Unit, Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., DeMarino C; Section for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Li W; Section for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Sampson K; Section for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Lee MH; Section for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Kowalak J; Clinical Proteomics Unit, Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Bhaskar M; NeuroTherapeutics Development Unit, Translational Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Doucet-O'Hare T; Section for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Garcia-Montojo M; Section for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Cowen M; Section for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Smith B; Section for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Reoma LB; Section for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Medina J; R&D division, GeNeuro Innovation, Lyon, France., Brunel J; R&D division, GeNeuro Innovation, Lyon, France., Pierquin J; R&D division, GeNeuro Innovation, Lyon, France., Charvet B; R&D division, GeNeuro Innovation, Lyon, France., Perron H; R&D division, GeNeuro Innovation, Lyon, France.; GeNeuro, Plan-les-Ouates, Switzerland., Nath A; Section for Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Publikováno v: Annals of neurology [Ann Neurol] 2022 Oct; Vol. 92 (4), pp. 545-561. Date of Electronic Publication: 2022 Jul 30.