Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bach-Cuc Nguyen"'
Autor:
Mohammed Muzamil Khan, Jennifer Frustino, Alessandro Villa, Bach-Cuc Nguyen, Sook-Bin Woo, William Evan Johnson, Xaralabos Varelas, Maria Kukuruzinska, Stefano Monti
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-14 (2023)
Abstract Head and neck cancers are a complex malignancy comprising multiple anatomical sites, with cancer of the oral cavity ranking among the deadliest and the most disfiguring cancers globally. Oral cancer (OC) constitutes a subset of head and neck
Externí odkaz:
https://doaj.org/article/eaa2919c9c4e499ab12c90416fae8b96
Autor:
Vinay K. Kartha, Khalid A. Alamoud, Khikmet Sadykov, Bach-Cuc Nguyen, Fabrice Laroche, Hui Feng, Jina Lee, Sara I. Pai, Xaralabos Varelas, Ann Marie Egloff, Jennifer E. Snyder-Cappione, Anna C. Belkina, Manish V. Bais, Stefano Monti, Maria A. Kukuruzinska
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-18 (2018)
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations
Externí odkaz:
https://doaj.org/article/3f10be2b6404420f97878bd8174c79b8
Autor:
Kenichi Nomoto, Stefano Monti, Bach-Cuc Nguyen, Manish V. Bais, Vanessa L. Stahl, Kevin B. Chandler, Takashi Owa, Catherine E. Costello, Vinay K. Kartha, Maria A. Kukuruzinska, Khalid Alamoud
Publikováno v:
Mol Omics
Epidermal growth factor receptor (EGFR) is a major driver of head and neck cancer, a devastating malignancy with a major sub-site in the oral cavity manifesting as oral squamous cell carcinoma (OSCC). EGFR is a glycoprotein receptor tyrosine kinase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236f08ee8c7cb8ef1e84eee0324f1778
https://doi.org/10.1039/d0mo00009d
https://doi.org/10.1039/d0mo00009d
Autor:
Maria A. Kukuruzinska, Kevin B. Chandler, Evan Ales, Robert Sackstein, Bach-Cuc Nguyen, Catherine E. Costello, Winston H. Elliott
Publikováno v:
Cancer Research. 81:2004-2004
Head and neck cancer is the seventh most common cancer in the world, claiming ~500,000 deaths yearly. Low expression of FUT2, an α1,2-fucosyltransferase that modifies glycoproteins and glycolipids, is associated with lower overall survival in head a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9596c0c615779ee6226fa3f58ba40902
https://doi.org/10.1158/1538-7445.am2021-2004
https://doi.org/10.1158/1538-7445.am2021-2004
Autor:
Stefano Monti, Khalid Alamoud, Huamei Yang, Xaralabos Varelas, Anthony Federico, Takashi Owa, Bach-Cuc Nguyen, Kenichi Nomoto, Vinay K. Kartha, Maria A. Kukuruzinska, Andrew Tilston-Lunel
Publikováno v:
Cancer Research. 80:2453-2453
Head and neck squamous cell carcinoma (HNSCC) is a pernicious malignancy that arises from populations of cancer stem cells (CSCs). We and others have shown that the Wnt/β-catenin signaling pathway drives CSC gene expression mediated, in part, by epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a3cb2004077574a098744a83cd46239
https://doi.org/10.1158/1538-7445.am2020-2453
https://doi.org/10.1158/1538-7445.am2020-2453
Autor:
Stefano Monti, Jin-A Lee, Manish V. Bais, Khikmet Sadykov, Khalid Alamoud, Hui Feng, Jennifer E. Snyder-Cappione, Ann Marie Egloff, Maria A. Kukuruzinska, Bach-Cuc Nguyen, Xaralabos Varelas, Vinay K. Kartha, Anna C. Belkina, Fabrice Laroche, Sara I. Pai
Publikováno v:
Genome Medicine
Genome Medicine, Vol 10, Iss 1, Pp 1-18 (2018)
Genome Medicine, Vol 10, Iss 1, Pp 1-18 (2018)
Background Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e66cc2aac86d0e39423aeb636a6090
https://doi.org/10.1186/s13073-018-0569-7
https://doi.org/10.1186/s13073-018-0569-7
Autor:
Kevin B. Chandler, Vanessa L. Stahl, Khalid Alamoud, Bach-Cuc Nguyen, Vinay Kartha, Khikmet Sadykov, Stefano Monti, Maria A. Kukuruzinska, Catherine E. Costello
Publikováno v:
Cancer Research. 79:2633-2633
Head and neck cancer is a debilitating malignancy, with the majority of cases arising in the oral cavity as oral squamous cell carcinoma (OSCC). A major driver of OSCC is the epidermal growth factor receptor (EGFR), whose activity is aberrantly upreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153907ce4dc79245a25c54bff1b70192
https://doi.org/10.1158/1538-7445.am2019-2633
https://doi.org/10.1158/1538-7445.am2019-2633
Autor:
Piotr Dziunycz, Karine Lefort, Elodie Ristorcelli, Gaetana Restivo, G. Paolo Dotto, Michael J. Dixon, Günther F.L. Hofbauer, Bach Cuc Nguyen, Russell J.H. Ryan, Özden Yalçin Özuysal, Freddy Radtke, Matteo Di Piazza
Publikováno v:
The EMBO Journal. 30:4571-4585
While the pro-differentiation and tumour suppressive functions of Notch signalling in keratinocytes are well established, the underlying mechanisms remain poorly understood. We report here that interferon regulatory factor 6 (IRF6), an IRF family mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ee89d4fda2e91191c6daa41d7818c8c
https://doi.org/10.1038/emboj.2011.325
https://doi.org/10.1038/emboj.2011.325
Autor:
Einar Castillo, YiPing Chen, Renuga Devi Rajaram, Karine Lefort, Wenying Qiu, Peter Angel, G. Paolo Dotto, Fenglei He, Cathrin Brisken, Bach Cuc Nguyen, Bing Hu
Publikováno v:
Genes & development
Epithelial–mesenchymal interactions are key to skin morphogenesis and homeostasis. We report that maintenance of the hair follicle keratinocyte cell fate is defective in mice with mesenchymal deletion of the CSL/RBP-Jκ gene, the effector of “can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78aacd48288b9777fa33bb665427c149
https://doi.org/10.1101/gad.1886910
https://doi.org/10.1101/gad.1886910
Publikováno v:
Journal of Biological Chemistry. 281:30463-30470
p21 plays a dual role in keratinocyte growth and differentiation control. It restricts the number of keratinocyte stem cell populations while inhibiting the later stages of differentiation independently of the cell cycle. The molecular/biochemical me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1604b9b892ccf75cfc1d75a5593393c4
https://doi.org/10.1074/jbc.m604684200
https://doi.org/10.1074/jbc.m604684200