Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Baca Chan"'
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The host immune system is engaged in a constant battle with microorganisms, with the immediate detection of pathogenic invasion and subsequent signalling acting as crucial deterrents against the establishment of a successful infection. For this purpo
Externí odkaz:
https://doaj.org/article/07a11bf4c61640a899c766dfb4dd6a28
Autor:
Baca Chan, Maja Arapović, Laura L. Masters, Francois Rwandamuiye, Stipan Jonjić, Lee M. Smith, Alec J. Redwood
Publikováno v:
Pathogens, Vol 10, Iss 7, p 866 (2021)
As the largest herpesviruses, the 230 kb genomes of cytomegaloviruses (CMVs) have increased our understanding of host immunity and viral escape mechanisms, although many of the annotated genes remain as yet uncharacterised. Here we identify the m15 l
Externí odkaz:
https://doaj.org/article/c01b576f6f094c2f8f14f8176c077a01
Autor:
Markus Fabits, Vladimir Gonçalves Magalhães, Baca Chan, Virginie Girault, Endrit Elbasani, Elisa Rossetti, Eirikur Saeland, Martin Messerle, Andreas Pichlmair, Vanda Juranić Lisnić, Melanie M. Brinkmann
Publikováno v:
Microorganisms, Vol 8, Iss 6, p 790 (2020)
The rapid activation of pattern recognition receptor (PRR)-mediated type I interferon (IFN) signaling is crucial for the host response to infection. In turn, human cytomegalovirus (HCMV) must evade this potent response to establish life-long infectio
Externí odkaz:
https://doaj.org/article/9ddf0413553e4fbd99aec82ec10b355c
Autor:
Baca Chan, Vladimir Gonçalves Magalhães, Niels A W Lemmermann, Vanda Juranić Lisnić, Markus Stempel, Kendra A Bussey, Elisa Reimer, Jürgen Podlech, Stefan Lienenklaus, Matthias J Reddehase, Stipan Jonjić, Melanie M Brinkmann
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006382 (2017)
The type I interferon (IFN) response is imperative for the establishment of the early antiviral immune response. Here we report the identification of the first type I IFN antagonist encoded by murine cytomegalovirus (MCMV) that shuts down signaling f
Externí odkaz:
https://doaj.org/article/e676e4e47d3342539c76ac11fcf03dfc
Autor:
Andrea R McWhorter, Lee M Smith, Laura L Masters, Baca Chan, Geoffrey R Shellam, Alec J Redwood
Publikováno v:
PLoS Pathogens, Vol 9, Iss 1, p e1003111 (2013)
It is becoming increasingly clear that many diseases are the result of infection from multiple genetically distinct strains of a pathogen. Such multi-strain infections have the capacity to alter both disease and pathogen dynamics. Infection with mult
Externí odkaz:
https://doaj.org/article/2c1058716fd949ec952a544d9e165b4b
Publikováno v:
Synthetic Biology
Diverse applications rely on engineering microbes to carry and express foreign transgenes. This engineered baggage rarely benefits the microbe and is thus prone to rapid evolutionary loss when the microbe is propagated. For applications where a trans
Autor:
Lee M. Smith, Alec J. Redwood, Maja Arapović, Francois Rwandamuiye, Laura L. Masters, Baca Chan, Stipan Jonjić
Publikováno v:
Pathogens
Volume 10
Issue 7
Pathogens, Vol 10, Iss 866, p 866 (2021)
Volume 10
Issue 7
Pathogens, Vol 10, Iss 866, p 866 (2021)
As the largest herpesviruses, the 230 kb genomes of cytomegaloviruses (CMVs) have increased our understanding of host immunity and viral escape mechanisms, although many of the annotated genes remain as yet uncharacterised. Here we identify the m15 l
Publikováno v:
Medical Microbiology and Immunology. 208:495-512
Early detection of viral invasion by pattern recognition receptors (PRR) is crucial for the induction of a rapid and efficient immune response. Cytosolic DNA sensors are the most recently described class of PRR, and induce transcription of type I int
Autor:
Catherine A. Forbes, Lee M. Smith, Laura L. Masters, Baca Chan, Berislav Lisnić, Stipan Jonjić, Alec J. Redwood, Shay Leary, Vanda Juranić Lisnić
Publikováno v:
Journal of Virology
Volume 94
Issue 22
J Virol
Volume 94
Issue 22
J Virol
The cloning of herpesviruses as bacterial artificial chromosomes (BACs) has revolutionized the study of herpesvirus biology, allowing rapid and precise manipulation of viral genomes. Several clinical strains of human cytomegalovirus (HCMV) have been
Autor:
Melanie M. Brinkmann, Andreas Pichlmair, Vanda Juranić Lisnić, Markus Fabits, Martin Messerle, Eirikur Saeland, Virginie Girault, Elisa Rossetti, Vladimir Gonçalves Magalhães, Baca Chan, Endrit Elbasani
Publikováno v:
Microorganisms
Volume 8
Issue 6
Switzerland
Microorganisms, Vol 8, Iss 790, p 790 (2020)
Volume 8
Issue 6
Switzerland
Microorganisms, Vol 8, Iss 790, p 790 (2020)
The rapid activation of pattern recognition receptor (PRR)-mediated type I interferon (IFN) signaling is crucial for the host response to infection. In turn, human cytomegalovirus (HCMV) must evade this potent response to establish life-long infectio