Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Baby Martin-McNulty"'
Autor:
Tzuhua D. Lin, Nimrod D. Rubinstein, Nicole L. Fong, Megan Smith, Wendy Craft, Baby Martin-McNulty, Rebecca Perry, Martha A. Delaney, Margaret A. Roy, Rochelle Buffenstein
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Naked mole-rats (NMRs) are best known for their extreme longevity and cancer resistance, suggesting that their immune system might have evolved to facilitate these phenotypes. Natural killer (NK) and T cells have evolved to detect and destro
Externí odkaz:
https://doaj.org/article/d02f7f07176341dc8d7d3f69378343c5
Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity.
Autor:
Hugo G Hilton, Nimrod D Rubinstein, Peter Janki, Andrea T Ireland, Nicholas Bernstein, Nicole L Fong, Kevin M Wright, Megan Smith, David Finkle, Baby Martin-McNulty, Margaret Roy, Denise M Imai, Vladimir Jojic, Rochelle Buffenstein
Publikováno v:
PLoS Biology, Vol 17, Iss 11, p e3000528 (2019)
The immune system comprises a complex network of specialized cells that protects against infection, eliminates cancerous cells, and regulates tissue repair, thus serving a critical role in homeostasis, health span, and life span. The subterranean-dwe
Externí odkaz:
https://doaj.org/article/7ccaa2b5062f41649723a8e1c83b849e
Autor:
Valdeci da Cunha, Baby Martin-McNulty, Jon Vincelette, Lening Zhang, John C. Rutledge, Dennis W. Wilson, Ronald Vergona, Mark E. Sullivan, Yi-Xin Wang
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 3, Pp 476-483 (2006)
Two month old C57BL/6 mice were placed on three different diets: 1) normal diet (NC; 0.025% cholesterol), 2) hypercholesterolemic Western-type diet (HC-W; 0.2% cholesterol), and 3) hypercholesterolemic Paigen-type diet (HC-P; 1.25% cholesterol plus 0
Externí odkaz:
https://doaj.org/article/e227057925374cc8a8394b43c49c1e84
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Background: The vascular system, like other organ systems, ages, leading to differences in remodeling due to injury. The hallmark of acute vascular injury is the formation of intimal hyperplasia. Vascular procedures performed in the elderly, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f47ae98bfbf510723ea86291e1e0e176
https://doi.org/10.1161/atvb.42.suppl_1.563
https://doi.org/10.1161/atvb.42.suppl_1.563
Autor:
Ganesh Kolumam, Guozhu Zhang, Mackenzie Leland, Hannah J. Donato, Gaven Garland, Johannes Riegler, Adam Freund, Andrew Deighan, Kevin M. Wright, Anil Raj, Gary A. Churchill, Baby Martin-McNulty, Laura Robinson
Publikováno v:
Genetics
Dietary interventions can dramatically affect physiological health and organismal lifespan. The degree to which organismal health is improved depends upon genotype and the severity of dietary intervention, but neither the effects of these factors, no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14765216469e1cd22bc932b95a61bfd
https://pubmed.ncbi.nlm.nih.gov/34791228
https://pubmed.ncbi.nlm.nih.gov/34791228
Autor:
Rochelle Buffenstein, Matthew Kukurugya, Vladimir Jojic, Jonathon J. O’Brien, Nicole V Haste, Celeste M. Sandoval, Bryson Bennett, Vikram Narayan, Ramin Rad, Adam Baker, Yao Wong, Carmela Sidrauski, Baby Martin-McNulty, Fiona E. McAllister, Phillip Seitzer, Megan Smith, Chunlian Zhang, Ganesh Kolumam, Aleksandr Gaun
Isotopic labeling with deuterium oxide (D2O) is a common technique for estimatingin vivoprotein turnover, but its use has been limited by two long-standing problems: (1) identifying non-monoisotopic peptides; and (2) estimating protein turnover rates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8b14a2c0f51ff25851e8a845e709cf
https://doi.org/10.1101/2020.11.10.377440
https://doi.org/10.1101/2020.11.10.377440
Autor:
David Finkle, Megan Smith, Denise M. Imai, Nicholas Bernstein, Baby Martin-McNulty, Margaret Ann Roy, Vladimir Jojic, Nimrod D. Rubinstein, Kevin M. Wright, Nicole L. Fong, Rochelle Buffenstein, Hugo G. Hilton, Peter Janki, Andrea T. Ireland
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 11, p e3000528 (2019)
PLoS Biology, Vol 17, Iss 11, p e3000528 (2019)
The immune system comprises a complex network of specialized cells that protects against infection, eliminates cancerous cells, and regulates tissue repair, thus serving a critical role in homeostasis, health span, and life span. The subterranean-dwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e65fd54db9c2b490a3d3762958cd4f9
https://pubmed.ncbi.nlm.nih.gov/31751331
https://pubmed.ncbi.nlm.nih.gov/31751331
Autor:
Kevin M. Wright, Baby Martin-McNulty, Margaret Ann Roy, David Finkle, Nimrod D. Rubinstein, Hugo G. Hilton, Vladimir Jojic, Megan Smith, Rochelle Buffenstein, Denise M. Imai, Peter Janki, Nicholas Bernstein, Andrea T. Ireland
Using single-cell transcriptional profiling we mapped the immune system of the naked mole-rat (Heterocephalus glaber), a small but long-lived and cancer-resistant subterranean rodent. Both splenic and circulating immune cells were examined in healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f257f3d54b8863a24603317303c8166
https://doi.org/10.1101/597195
https://doi.org/10.1101/597195
Autor:
Allie Maltzman, Patrick Caplazi, Wyne P. Lee, Domagoj Vucic, Joshua D. Webster, Debra L. Dugger, Juan Zhang, Baby Martin-McNulty, N. van Bruggen, Jason DeVoss, Joan M. Greve, Brent S. McKenzie, Lauri Diehl, Ivan Peng, Kim Newton, Xiumin Wu, Tim C. Cao, Surinder Jeet, Lisa J. Bernstein, Maj Hedehus, Merone Roose-Girma, Richard A.D. Carano
Publikováno v:
Cell Death and Differentiation
Necroptosis is a caspase-independent form of cell death that is triggered by activation of the receptor interacting serine/threonine kinase 3 (RIPK3) and phosphorylation of its pseudokinase substrate mixed lineage kinase-like (MLKL), which then trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d4b49477ab1b9581c914016a9c96c5
https://doi.org/10.1038/cdd.2016.46
https://doi.org/10.1038/cdd.2016.46
Autor:
Richard A.D. Carano, Ryan J. Watts, Stephen J. Tam, Tim C. Cao, Zora Modrusan, Baby Martin-McNulty, Joshua S. Kaminker, Nick van Bruggen, Robby M. Weimer, David L. Richmond
Publikováno v:
Developmental Cell. 22(2):403-417
Summary Signaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barrier (BBB) formation are only beginning to be elucidated. By evaluating the gene expression profile of mouse vasculature, we identified DR6/TNFRSF21 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74409c64970bc5e1ed0314a57d49919