Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Babu Sudhamalla"'
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8834 (2010)
BACKGROUND: Human serum albumin (HSA) is the most abundant protein in blood plasma, having high affinity binding sites for several endogenous and exogenous compounds. Trimethoxy flavone (TMF) is a naturally occurring flavone isolated from Andrographi
Externí odkaz:
https://doaj.org/article/a6e0e19fe6a142819158f6e7a1419487
Publikováno v:
Biochemical Journal. 480:629-647
TRIM24 is a multi-functional chromatin reader, and it binds to the estrogen receptor to activate estrogen-dependent target genes associated with tumor development. TRIM24 is known to ubiquitinate p53 via an N-terminal RING domain and binds a specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a863400feb9727d4156271036f12d943
https://doi.org/10.1042/bcj20230011
https://doi.org/10.1042/bcj20230011
Autor:
Avisek Bera, Pooja Ghosh, Soumen Barman, Sagnik Bhattacharya, Babu Sudhamalla, Kalyan Goswami, Priyadarsi De
Publikováno v:
Biomaterials Science. 11:3574-3588
Glycopolymeric nanoassemblies were designed with engineered projection of either selective or both cationic leucine/sugar residues on the outer surface of the aggregates to explore their potential role in preventing insulin fibrillation process.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4956da565d920d85264d42c5c7d1ced3
https://doi.org/10.1039/d2bm02078e
https://doi.org/10.1039/d2bm02078e
Publikováno v:
RSC Chemical Biology. 3:1061-1068
Bromodomain containing protein 1 (BRD1) plays critical roles in chromatin acetylation, gene transcription, erythropoiesis, and brain development. BRD1 is also implicated in several human conditions and is a therapeutic target for cancer. Although, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e267e221e1973537b0b7af8774ef133d
https://doi.org/10.1039/d2cb00043a
https://doi.org/10.1039/d2cb00043a
Bromodomains are evolutionarily conserved structural motifs that recognize acetylated lysine residues on histone tails. They play a crucial role in shaping chromatin architecture and regulating gene expression in various biological processes. Mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3b082691ce7eb212468b61160b92af
https://doi.org/10.1101/2022.11.25.517921
https://doi.org/10.1101/2022.11.25.517921
Autor:
Ishita Bardhan, Shivani Shivani, Thirukumaran Kandasamy, Babu Sudhamalla, Anirban Roy, Soumen Barman
Publikováno v:
Chemistry – An Asian Journal. 16:3404-3412
Bromodomains are evolutionarily conserved reader modules that recognize acetylated lysine residues on the histone tails to facilitate the transcription of target genes. The bromodomain and PHD finger containing protein 3 (BRPF3) is a scaffolding prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9926066e49b5640b68241d17cc3a087
https://doi.org/10.1002/asia.202100793
https://doi.org/10.1002/asia.202100793
Publikováno v:
J Am Chem Soc
Conditional remodeling of enzyme catalysis is a formidable challenge in protein engineering. Herein, we have undertaken a unique active site engineering tactic to command catalytic outcome. With ten-eleven translocation (TET) enzyme as a paradigm, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533b57e5b74b3f79649dbe31cdefb248
https://doi.org/10.1021/jacs.1c03815
https://doi.org/10.1021/jacs.1c03815
Publikováno v:
Biochemistry.
Combinatorial readout of histone post-translational modifications by tandem reader modules mediates crosstalk among different histone modifications. To identify the domain-specific interactome of the tandem reader, we engineered the dual bromodomain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f65501d45f1c1c6c59a700d1c969358
https://pubmed.ncbi.nlm.nih.gov/35786907
https://pubmed.ncbi.nlm.nih.gov/35786907
Publikováno v:
Biochemical Journal. 480:751-751
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc1eac4b0108712db8f6cea8b5935f3a
https://doi.org/10.1042/bcj-2023-0011_cor
https://doi.org/10.1042/bcj-2023-0011_cor
Publikováno v:
Chemical Communications. 57:9866-9869
The site-specific installation of light-activable crosslinker unnatural amino acids offers a powerful approach to trap transient protein-protein interactions both in vitro and in vivo. Herein, we engineer a bromodomain to introduce 4-benzoyl-L-phenyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc910144185ee2f976ab6abc04388522
https://doi.org/10.1039/d1cc04611j
https://doi.org/10.1039/d1cc04611j