Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Babu G, Sundar"'
Autor:
Beverly P. Holskin, Karla Kopec, Joanne R. Mathiasen, Amy DiCamillo, Babu G. Sundar, Thomas J. Connors, Emir Duzic, Edward R. Bacon, Gerard C. Rosse, Chrysanthe Spais, Thomas R. Bailey, Beth Ann McKenna, Rebecca A. Brown, Jie Qian, Derek Dunn, Mark J. Huffman, Joseph M. Salvino, Huang Zeqi, Lisa D. Aimone, Hervé Schaffhauser, Deborah Galinis, Thelma S. Angeles, Lily D. Lu, George C. Morton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:120-123
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a63c099e60dd280977edea44193b5a96
https://doi.org/10.1016/j.bmcl.2011.11.050
https://doi.org/10.1016/j.bmcl.2011.11.050
Autor:
Edward R. Bacon, Jacquelyn A. Lyons, Thomas R. Bailey, Robert L. Hudkins, Rita Raddatz, Zeqi Huang, Lisa D. Aimone, Babu G. Sundar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5543-5546
Pyridazinone 1 was recently reported as a potent H(3)R antagonist with good drug-like properties and in vivo activity. A series of constrained amine analogs of 1 was synthesized to identify compounds with improved pharmacokinetic profiles. From these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffc7c01c2c829144a59308dbfd8e377e
https://doi.org/10.1016/j.bmcl.2011.06.094
https://doi.org/10.1016/j.bmcl.2011.06.094
Autor:
Kurt A. Josef, Allison L. Zulli, Lisa D. Aimone, Derek Dunn, Rita Raddatz, Jacquelyn A. Lyons, Ming Tao, Joanne R. Mathiasen, Reddeppa reddy Dandu, Thomas R. Bailey, Val R. Marcy, Babu G. Sundar, John A. Gruner, Edward R. Bacon, Robert L. Hudkins, Robert J. Bendesky, Yin-Guo Lin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5493-5497
H3R structure–activity relationships on a novel class of pyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone core, central phenyl ring and linker led to the identification of molecules with excellent ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a0a37d3e55238ac5c8227f7564e4b97
https://doi.org/10.1016/j.bmcl.2011.06.108
https://doi.org/10.1016/j.bmcl.2011.06.108
Publikováno v:
Synthetic Communications. 41:1481-1485
Thermal rearrangement of aminoimine, 1, followed by hydrogenation produced 1-phenyl-2-pyrrolidinyl cyclopentylamine 3. The structure and stereochemistry of this novel amine 4 was identified by x-ray crystallography of the 2-chloro-6-iodo-nicotinamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24bd4a7d0f48cbad84edb9c2609f9825
https://doi.org/10.1080/00397911.2010.486513
https://doi.org/10.1080/00397911.2010.486513
Autor:
Babu G, Sundar, Thomas R, Bailey, Derek D, Dunn, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Huang, Zeqi, Joanne R, Mathiasen, Amy, Dicamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Rebecca, Brown, Jie, Qian, Thelma, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Deborah, Galinis, Emir, Duzic, Herve, Schaffhauser, Gerard C, Rosse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b0ab8369735ed85da9712148db21027
https://pubmed.ncbi.nlm.nih.gov/22153937
https://pubmed.ncbi.nlm.nih.gov/22153937
Publikováno v:
ChemInform. 42
Thermal rearrangement of aminoimine, 1, followed by hydrogenation produced 1-phenyl-2-pyrrolidinyl cyclopentylamine 3. The structure and stereochemistry of this novel amine 4 was identified by x-ray crystallography of the 2-chloro-6-iodo-nicotinamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d37ae6fddf29e8bc5c35fc9e82343e80
https://doi.org/10.1002/chin.201144098
https://doi.org/10.1002/chin.201144098
Autor:
Robert L, Hudkins, Lisa D, Aimone, Thomas R, Bailey, Robert J, Bendesky, Reddeppa Reddy, Dandu, Derek, Dunn, John A, Gruner, Kurt A, Josef, Yin-Guo, Lin, Jacquelyn, Lyons, Val R, Marcy, Joanne R, Mathiasen, Babu G, Sundar, Ming, Tao, Allison L, Zulli, Rita, Raddatz, Edward R, Bacon
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
H(3)R structure-activity relationships on a novel class of pyridazin-3-one H(3)R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone core, central phenyl ring and linker led to the identification of molecules with excellent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::751b027788338fa7af0c76f12a30b863
https://pubmed.ncbi.nlm.nih.gov/21782432
https://pubmed.ncbi.nlm.nih.gov/21782432
Autor:
Babu G, Sundar, Thomas, Bailey, Edward, Bacon, Lisa, Aimone, Zeqi, Huang, Jacquelyn, Lyons, Rita, Raddatz, Robert, Hudkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
Pyridazinone 1 was recently reported as a potent H(3)R antagonist with good drug-like properties and in vivo activity. A series of constrained amine analogs of 1 was synthesized to identify compounds with improved pharmacokinetic profiles. From these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8196628b9170a7a7ccee21d28ca165b
https://pubmed.ncbi.nlm.nih.gov/21824776
https://pubmed.ncbi.nlm.nih.gov/21824776