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pro vyhledávání: '"Babu, Suresh D."'
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Autor:
Babu Suresh D, R. Kuvelkar, Yuhua Huang, A.W. Stamford, Qi Zhang, Lili Zhang, P. Gaspari, J. Pan, Wang Lingyan, L. Ozgur, Ge Li, Yusheng Wu, Johannes H. Voigt, Xiao Chen, Kurt W. Saionz, J. Lowrie, Tao Guo, Ulrich Iserloh, N.A. McHugh, D. Tadesse, Le Thuy X H, Matthew E. Kennedy, Doug W. Hobbs, Leonard Favreau, Carolyn DiIanni Carroll, Corey Strickland, Jared N. Cumming, Eric M. Parker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3236-3241
Guided by structure-based design, we synthesized two novel series of potent inhibitors of BACE1 and generated extensive SAR around both the prime and non-prime side binding pockets. The key feature of both series is a cyclic amine motif specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecdbdfa7bbf11174961bb58e02315b3
https://doi.org/10.1016/j.bmcl.2008.04.050
https://doi.org/10.1016/j.bmcl.2008.04.050
Autor:
Peter Orth, Kathleen Cox, Corey Strickland, Rachael C. Hunter, Reshma Kuvelkar, Eric J. Gilbert, Lynn A. Hyde, Jared N. Cumming, Sarah W. Li, Chunli Huang, Eric M. Parker, Johannes H. Voigt, Yusheng Wu, Matthew E. Kennedy, Andrew Stamford, William J. Greenlee, Zhaoning Zhu, Dawit Tadesse, Liwu Hong, Babu Suresh D, Misiaszek Jeffrey A, Xia Chen, Tao Guo, Robert A. Hodgson, Jack D. Scott, Mckittrick Brian A, Leonard Favreau
Publikováno v:
ACS medicinal chemistry letters. 3(11)
Inhibition of BACE1 to prevent brain Aβ peptide formation is a potential disease-modifying approach to the treatment of Alzheimer’s disease. Despite over a decade of drug discovery efforts, the identification of brain-penetrant BACE1 inhibitors th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e05bfa746e1637b58bc5fb6a90933c9
https://pubmed.ncbi.nlm.nih.gov/23412139
https://pubmed.ncbi.nlm.nih.gov/23412139
Autor:
Babu Suresh D, Leigh Wierichs, Suzanne Walker, Natan A. Kogan, Michael J. Sofia, Karen Bruker, Ramesh Kakarla, Helena R. Axelrod, Clifford B. Longley, Sunita Midha, Daniel Kahne
Publikováno v:
Proceedings of the National Academy of Sciences. 93:1585-1590
A promising class of compounds for DNA transfection have been designed by conjugating various polyamines to bile-acid-based amphiphiles. Formulations containing these compounds were tested for their ability to facilitate the uptake of a beta-galactos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8205ded88c6b73d16ebf384df7cea67d
https://doi.org/10.1073/pnas.93.4.1585
https://doi.org/10.1073/pnas.93.4.1585
Autor:
Cinzia Cantu, Dawit Tadesse, Eric M. Parker, Yusheng Wu, Jack D. Scott, Babu Suresh D, Robert A. Hodgson, Giuseppe Terracina, Prescott T. Leach, Xia Chen, Tao Guo, Lynn A. Hyde, Maxine Chen, Wei Li, Bonnie J. Werner, Matthew E. Kennedy, Lili Zhang, Qi Zhang, Misiaszek Jeffrey A, Andrew Stamford
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3b90e64c5f16a206dc210cc29361299
https://doi.org/10.1016/j.jalz.2010.05.1773
https://doi.org/10.1016/j.jalz.2010.05.1773
Autor:
Tatiana M. Kazdoba, Giuseppe Terracina, Eric M. Parker, Lynn A. Hyde, Matthew E. Kennedy, Robert A. Del Vecchio, Dawit Tadese, Ronald Manning, Lili Zhang, Qi Zhang, Andrew Stamford, Tao Guo, Babu Suresh D
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::252bbc102af1c360253faae4d0ae22c3
https://doi.org/10.1016/j.jalz.2010.05.1799
https://doi.org/10.1016/j.jalz.2010.05.1799
Autor:
Reshma Kuvelkar, Peter Orth, Nansie A. McHugh, Xia Chen, Corey Strickland, Carolyn Carrol, Babu Suresh D, Eric M. Parker, Jared N. Cumming, Dawit Tadesse, Guoqing Li, Johannes H. Voigt, Le Thuy X H, Lynne E. Ozgur, Matthew E. Kennedy, Kurt W. Saionz, William J. Greenlee, Tao Guo, Ying Huang, Andrew Stamford, Lili Zhang, Qi Zhang, Leonard Favreau
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(9)
With collaboration between chemistry, X-ray crystallography, and molecular modeling, we designed and synthesized a series of novel piperazine sulfonamide BACE1 inhibitors. Iterative exploration of the non-prime side and S2{prime} sub-pocket of the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce47ecc08f0df426003b46dd9c6b44f
https://pubmed.ncbi.nlm.nih.gov/20347593
https://pubmed.ncbi.nlm.nih.gov/20347593
Autor:
Huizhong Gu, Babu Suresh D, Laura L. Rokosz, Tara M. Stauffer, Doug W. Hobbs, Tao Guo, Rachael C. Hunter, Qian Gang, Yuefei Shao
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(16)
An encoded combinatorial library based on aryl and biaryl piperidine scaffolds was designed and synthesized. Screening of this library resulted in the discovery of high-nanomolar biaryl piperidine-based MCH1 receptor antagonists. Follow-up optimizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5873a7c738fd59c7096287b6c9e5cbd8
https://pubmed.ncbi.nlm.nih.gov/15978811
https://pubmed.ncbi.nlm.nih.gov/15978811
Autor:
Anna Gall, Chris Lum, Sherry Nelson, Bolong Cao, Minh Nguyen, Ryan Minarik, Babu Suresh D, Hiroshi Nakanishi, Michael Kann, Fuqiang Ruan, Joseph Patrick Meara, Tulinsky John E, Maher Qabar, Mark A. T. Blaskovich, P. Douglas Boatman, Jan Urban, Cyprian O. Ogbu, Little Thomas L, Mark D. Ferguson
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(17)
The general approach of using a bicyclic template to produce inhibitors of the protease superfamily of enzymes has been investigated. The Diels Alder cycloaddition reaction on solid support has been found to be highly efficient for the synthesis of l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31006bb2aa8fed8ba519dbb3edc90e8
https://pubmed.ncbi.nlm.nih.gov/9873535
https://pubmed.ncbi.nlm.nih.gov/9873535
Autor:
C. Longley, Babu Suresh D, N. Kogan, H. Axelrod, R. Kakarla, Suzanne Walker, L. Wierichs, M. Sofia, S. Midha
Publikováno v:
Annals of the New York Academy of Sciences. 772
We have designed novel glycosteroid-polyamines for transmembrane DNA delivery based on amphiphilic drug transport agents. These glycosteroid-based agents show promise as viable DNA delivery technology for gene therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459cfe6b68feedfec3219715157166c0
https://pubmed.ncbi.nlm.nih.gov/8546405
https://pubmed.ncbi.nlm.nih.gov/8546405