Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Babine, Robert E."'
Autor:
Jin, Lei ‡, Pandey, Pramod, Babine, Robert E., Gorga, Joan C., Seidl, Katherine J., Gelfand, Ellen, Weaver, David T., Abdel-Meguid, Sherin S., Strickler, James E.
Publikováno v:
In Journal of Biological Chemistry 11 February 2005 280(6):4704-4712
Publikováno v:
Expert Opinion on Therapeutic Patents. 15:555-573
Immunophilins are a family of binding proteins that are highly conserved in nature and mediate the actions of immunosuppressant drugs. The FK-506-binding protein (FKBP) subclass of immunophilin bind FK-506 and rapamycin and are of particular interest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4d7cc3a76169972b67c311c39dc6abf
https://doi.org/10.1517/13543776.15.5.555
https://doi.org/10.1517/13543776.15.5.555
Autor:
Babine Robert E, Edward L. Brown, David A. Matthews, Susan L. Binford, Stephen T. Worland, Shella A. Fuhrman, Amy K. Patick, James E. V. Harr, Reich Siegfried Heinz, Joseph T. Marakovits, Thomas J. Prins, Caroline A. Lee, Wallace Michael B, Peter S. Dragovich, Littlefield Ethel S, and Dorothy M. DeLisle, James W. Meador, Rose Ann Ferre, Clifford E. Ford, Ru Zhou, Stephen E. Webber, Jayashree Tikhe
Publikováno v:
Journal of Medicinal Chemistry. 41:2819-2834
The structure-based design, chemical synthesis, and biological evaluation of various peptide-derived human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. These compounds are comprised of an ethyl propenoate Michael acceptor moiety and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ae4560588b9aa6544425b6ac69eedc
https://doi.org/10.1021/jm9800696
https://doi.org/10.1021/jm9800696
Autor:
Steven L. Bender, Babine Robert E
Publikováno v:
Chemical Reviews. 97:1359-1472
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::615ee7d02e3e63c41d43e26e4a642d1e
https://doi.org/10.1021/cr960370z
https://doi.org/10.1021/cr960370z
Autor:
Susumo Katoh, J. Ernest Villafranca, Cristina T. Lewis, Michael Imbacuan, Richard E. Showalter, Babine Robert E, Littlefield Ethel S, Judy V. French, Hans E. Parge, Ted M. Bleckman, John H. Tatlock, L. A. K. Pelletier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:385-390
The design, synthesis, and structure activity relationships of a series of novel macrocyclic FKBP-12 ligands 1 are reported. The crystal structure of the complex between 7 and human FKBP-12 is reported and some SAR results are discussed based on this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d40c1f82d7ab92eaa7836f31e40e88c9
https://doi.org/10.1016/0960-894x(96)00032-7
https://doi.org/10.1016/0960-894x(96)00032-7
Autor:
C. T. Lewis, Babine Robert E, Charles R. Kissinger, Ted M. Bleckman, Richard E. Showalter, J. Ernest Villafranca, Kathleen D. Tucker, L. A. K. Pelletier, Hans E. Parge, Ellen W. Moomaw
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1719-1724
Using the crystal structure of FKBP-12 a novel class of ligands were designed, prepared and evaluated. The crystal structure of the complex between 5 and FKBP-12 is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e618be6998fefcd8472870a7767fd495
https://doi.org/10.1016/0960-894x(95)00290-a
https://doi.org/10.1016/0960-894x(95)00290-a
Autor:
S. Katoh, M. Imbacuan, John H. Tatlock, Littlefield Ethel S, R. E. Showalter, Babine Robert E, Hans E. Parge, C. T. Lewis, Jesus Ernesto Villafranca, T. M. Bleckman, J. V. French, L. A. K. Pelletier
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ddb3aaa3478b7f9137307134152fcef
https://doi.org/10.1002/chin.199625159
https://doi.org/10.1002/chin.199625159
Autor:
Babine Robert E, Steven L. Bender
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73537e78f090fb7c69ab0ab1f6e3c84c
https://doi.org/10.1002/chin.199744334
https://doi.org/10.1002/chin.199744334
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Autor:
Deng, Hongfeng, Bannister, Thomas D., Jin, Lei, Babine, Robert E., Quinn, Jesse, Nagafuji, Pamela, Celatka, Cassandra A., Lin, Jian, Lazarova, Tsvetelina I., Rynkiewicz, Michael J., Bibbins, Frank, Pandey, Pramod, Gorga, Joan, Meyers, Harold V., Abdel-Meguid, Sherin S., Strickler, James E.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2006 16(11):3049-3054