Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide.

Autor: Sukumar UK; Cellular Pathway Imaging Laboratory (CPIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 3155 Porter Drive, Palo Alto, CA, 94305, USA., Bose RJC; Cellular Pathway Imaging Laboratory (CPIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 3155 Porter Drive, Palo Alto, CA, 94305, USA., Malhotra M; Laboratory of Experimental and Molecular Neuroimaging (LEMNI), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 300 Pasteur Drive, Grant Bldg. S031, Stanford, CA, 94305, USA., Babikir HA; Laboratory of Experimental and Molecular Neuroimaging (LEMNI), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 300 Pasteur Drive, Grant Bldg. S031, Stanford, CA, 94305, USA., Afjei R; Laboratory of Experimental and Molecular Neuroimaging (LEMNI), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 300 Pasteur Drive, Grant Bldg. S031, Stanford, CA, 94305, USA., Robinson E; Cellular Pathway Imaging Laboratory (CPIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 3155 Porter Drive, Palo Alto, CA, 94305, USA., Zeng Y; Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305-4034, United States., Chang E; Multimodality Molecular Imaging Laboratory (MMIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, Clark Center, 318 Campus Drive, Stanford, CA, 94305, USA., Habte F; Cellular Pathway Imaging Laboratory (CPIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 3155 Porter Drive, Palo Alto, CA, 94305, USA., Sinclair R; Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305-4034, United States., Gambhir SS; Multimodality Molecular Imaging Laboratory (MMIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, Clark Center, 318 Campus Drive, Stanford, CA, 94305, USA., Massoud TF; Laboratory of Experimental and Molecular Neuroimaging (LEMNI), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 300 Pasteur Drive, Grant Bldg. S031, Stanford, CA, 94305, USA. Electronic address: tmassoud@stanford.edu., Paulmurugan R; Cellular Pathway Imaging Laboratory (CPIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, 3155 Porter Drive, Palo Alto, CA, 94305, USA. Electronic address: paulmur8@stanford.edu.

Publikováno v: Biomaterials [Biomaterials] 2019 Oct; Vol. 218, pp. 119342. Date of Electronic Publication: 2019 Jul 12.

Targeted nanoparticle delivery of therapeutic antisense microRNAs presensitizes glioblastoma cells to lower effective doses of temozolomide in vitro and in a mouse model.

Autor: Malhotra M; Laboratory for Experimental and Molecular Neuroimaging (LEMNI), Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305, USA., Sekar TV; Cellular Pathway Imaging Laboratory (CPIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, Palo Alto, CA 94305, USA., Ananta JS; Laboratory for Experimental and Molecular Neuroimaging (LEMNI), Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305, USA., Devulapally R; Cellular Pathway Imaging Laboratory (CPIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, Palo Alto, CA 94305, USA., Afjei R; Laboratory for Experimental and Molecular Neuroimaging (LEMNI), Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305, USA., Babikir HA; Laboratory for Experimental and Molecular Neuroimaging (LEMNI), Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305, USA., Paulmurugan R; Cellular Pathway Imaging Laboratory (CPIL), Molecular Imaging Program at Stanford, Stanford University School of Medicine, Palo Alto, CA 94305, USA., Massoud TF; Laboratory for Experimental and Molecular Neuroimaging (LEMNI), Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305, USA.

Publikováno v: Oncotarget [Oncotarget] 2018 Apr 20; Vol. 9 (30), pp. 21478-21494. Date of Electronic Publication: 2018 Apr 20 (Print Publication: 2018).

Drep-2 is a novel synaptic protein important for learning and memory.

Autor: Andlauer TF; Genetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany., Scholz-Kornehl S; Genetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany., Tian R; Genetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany., Kirchner M; Department of Cell Signalling and Mass Spectrometry, Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, Germany., Babikir HA; Genetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany., Depner H; Genetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany., Loll B; Institute of Chemistry and Biochemisty, Freie Universität Berlin, Berlin, Germany., Quentin C; Genetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany., Gupta VK; Genetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany., Holt MG; Department Laboratory of Glia Biology, Vlaams Instituut voor Biotechnologie (VIB) Center for the Biology of Disease, Katholieke Universiteit Leuven, Leuven, Belgium., Dipt S; Department of Molecular Neurobiology of Behavior, Georg-August-Universität Göttingen, Göttingen, Germany., Cressy M; Department of Neuroscience, Cold Spring Harbor Laboratory, Cold Spring Harbor, United States., Wahl MC; Institute of Chemistry and Biochemisty, Freie Universität Berlin, Berlin, Germany., Fiala A; Department of Molecular Neurobiology of Behavior, Georg-August-Universität Göttingen, Göttingen, Germany., Selbach M; Department of Cell Signalling and Mass Spectrometry, Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, Germany., Schwärzel M; Genetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany., Sigrist SJ; Genetics, Institute of Biology, Freie Universität Berlin, Berlin, Germany.

Publikováno v: ELife [Elife] 2014 Nov 13; Vol. 3. Date of Electronic Publication: 2014 Nov 13.