Výsledky vyhledávání - "Babenko Vladimir N"

Akademický článek

Computer Analysis of Glioma Transcriptome Profiling: Alternative Splicing Events

Autor: Babenko Vladimir N., Gubanova Natalya V., Bragin Anatoly O., Chadaeva Irina V., Vasiliev Gennady V., Medvedeva Irina V., Gaytan Alexey S., Krivoshapkin Alexey L., Orlov Yuriy L.

Publikováno v: Journal of Integrative Bioinformatics, Vol 14, Iss 3, Pp 513-26 (2017)

Here we present the analysis of alternative splicing events on an example of glioblastoma cell culture samples using a set of computer tools in combination with database integration. The gene expression profiles of glioblastoma were obtained from cel

Externí odkaz: https://doaj.org/article/8ae52f5405164a7dbeb30856e4c049d6

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Akademický článek

Analysis of differential gene expression by RNA-seq data in brain areas of laboratory animals

Autor: Babenko Vladimir N., Bragin Anatoly O., Spitsina Anastasia M., Chadaeva Irina V., Galieva Elvira R., Orlova Galina V., Medvedeva Irina V., Orlov Yuriy L.

Publikováno v: Journal of Integrative Bioinformatics, Vol 13, Iss 4, Pp 1-15 (2016)

Computer analysis of gene expression in the nervous system plays a fundamental role in biology, genetics, and neurosciences. We studied molecular and genetic mechanisms of enhanced aggressiveness in comparison with tolerant behaviour using experiment

Externí odkaz: https://doaj.org/article/6ce4ce4d71dc4733b53f800eef551516

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Akademický článek

RNA-Seq Mouse Brain Regions Expression Data Analysis: Focus on ApoE Functional Network

Autor: Babenko Vladimir N., Smagin Dmitry A., Kudryavtseva Natalia N.

Publikováno v: Journal of Integrative Bioinformatics, Vol 14, Iss 3, Pp R903-8 (2017)

ApoE expression status was proved to be a highly specific marker of energy metabolism rate in the brain. Along with its neighbor, Translocase of Outer Mitochondrial Membrane 40 kDa (TOMM40) which is involved in mitochondrial metabolism, the correspon

Externí odkaz: https://doaj.org/article/80fbce5fc8854d1091e528eb04736a05

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Akademický článek

Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster

Autor: Demakov Sergey A, Yu Vatolina Tatyana, Babenko Vladimir N, Semeshin Valery F, Belyaeva Elena S, Zhimulev Igor F

Publikováno v: BMC Genomics, Vol 12, Iss 1, p 566 (2011)

Abstract Background Despite many efforts, little is known about distribution and interactions of chromatin proteins which contribute to the specificity of chromomeric organization of interphase chromosomes. To address this issue, we used publicly ava

Externí odkaz: https://doaj.org/article/9916d4cc6c0d46e9b7671512a8970f49

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Akademický článek

Paucity and preferential suppression of transgenes in late replication domains of the D. melanogaster genome

Autor: Maroy Peter, Belyakin Stepan N, Maksimov Daniil A, Belyaeva Elena S, Brusentsova Irina V, Makunin Igor V, Babenko Vladimir N, Vasil'eva Lyubov A, Zhimulev Igor F

Publikováno v: BMC Genomics, Vol 11, Iss 1, p 318 (2010)

Abstract Background Eukaryotic genomes are organized in extended domains with distinct features intimately linking genome structure, replication pattern and chromatin state. Recently we identified a set of long late replicating euchromatic regions th

Externí odkaz: https://doaj.org/article/f0c6ff3bcbce42a3ba613f6e836a3dff

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Akademický článek

Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis

Autor: Rogozin Igor B, Kondrashov Fyodor A, Basu Malay K, Babenko Vladimir N, Koonin Eugene V

Publikováno v: BMC Cancer, Vol 6, Iss 1, p 36 (2006)

Abstract Background Carcinogenesis typically involves multiple somatic mutations in caretaker (DNA repair) and gatekeeper (tumor suppressors and oncogenes) genes. Analysis of mutation spectra of the tumor suppressor that is most commonly mutated in h

Externí odkaz: https://doaj.org/article/1cdb0347af88456b80bfb1c484dfc485

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Akademický článek

Mutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection

Autor: Koonin Eugene V, Babenko Vladimir N, Glazko Galina V, Rogozin Igor B

Publikováno v: Biology Direct, Vol 1, Iss 1, p 4 (2006)

Abstract Background The mutation spectra of the TP53 gene and other tumor suppressors contain multiple hotspots, i.e., sites of non-random, frequent mutation in tumors and/or the germline. The origin of the hotspots remains unclear, the general view

Externí odkaz: https://doaj.org/article/534c20970986490c80244890fc3688d8

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