Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Babatomiwa Kikiowo"'
Autor:
Opeyemi Iwaloye, Paul Olamide Ottu, Femi Olawale, Olorunfemi Oyewole Babalola, Olusola Olalekan Elekofehinti, Babatomiwa Kikiowo, Abayomi Emmanuel Adegboyega, Henry Nnaemeka Ogbonna, Covenant Femi Adeboboye, Ibukun Mary Folorunso, Aderonke Elizabeth Fakayode, Moses Orimoloye Akinjiyan, Sunday Amos Onikanni, Sergey Shityakov
Publikováno v:
Informatics in Medicine Unlocked, Vol 41, Iss , Pp 101332- (2023)
The escalating prevalence of cancer on a global scale, coupled with the inadequacies of present-day therapies and the emergence of drug-resistant cancer strains, has necessitated the development of additional anticancer drugs. The traditional drug di
Externí odkaz:
https://doaj.org/article/6cb83284931b4498a720fa901f2146ec
Autor:
Babatomiwa Kikiowo, Adewale Joseph Ogunleye, Olumide Kayode Inyang, Niyi Samuel Adelakun, Olaposi Idowu Omotuyi, Damilohun Samuel Metibemu, Temitope Israel David, Oluwatoyin Olajide Oludoyi, Taiwo Tolulope Ijatuyi
Publikováno v:
BioImpacts, Vol 10, Iss 4, Pp 227-234 (2020)
Introduction: Gout is a type of painful inflammation initiated by the interactions between monosodium urate crystals and connective tissue. Xanthine oxidase (XO) catalyzes the oxidation of hypoxanthine to xanthine, then to uric acid. The primary trea
Externí odkaz:
https://doaj.org/article/58b6d89a42f04332bf21889bf8391a2c
Autor:
Opeyemi Iwaloye, Olusola Olalekan Elekofehinti, Femi Olawale, Prosper Obed Chukwuemeka, Babatomiwa Kikiowo, Ibukun Mary Folorunso
Publikováno v:
Letters in Drug Design & Discovery. 20:317-334
Background: Plasmodium falciparum dihydroorotate dehydrogenase (PfDODH) is one of the enzymes currently explored in the treatment of malaria. Although there is currently no clinically approved drug targeting PfDODH, many of the compounds in clinical
Autor:
Olusola Olalekan Elekofehinti, Opeyemi Iwaloye, Babatomiwa Kikiowo, Toyin Mary Fadipe, Emmanuel A. Oluwarotimi
Publikováno v:
Current Proteomics. 18:753-769
Background: P-21 activating kinase 4 (PAK4) is implicated in the poor prognosis of many cancers, especially in the progression of Triple Negative Breast Cancer (TNBC). The present study was aimed at designing some potential drug candidates as PAK4 in
Autor:
Femi Olawale, Abayomi Emmanuel Adegboyega, Olushola Olalekan Elekofehinti, Kayode Michael Ilesanmi, Isaac Damilola Akinropo, Emmanuel A. Oluwarotimi, Babatomiwa Kikiowo, Oluwaseun Benedicta Akinlosotu, Taiwo Emmanuel Ologuntere, Opeyemi Iwaloye
Publikováno v:
Letters in Drug Design & Discovery. 18:1009-1023
Background: Cancer is a multifactorial disease with multiple complications involving multiple proteins. Breast cancer is the most prevalent form of cancer among women. The pathophysiology of this cancer form has implicated several genetic alterations
Autor:
Babatomiwa Kikiowo, Iqrar Ahmad, Adebowale A. Alade, Taiwo T. Ijatuyi, Opeyemi Iwaloye, Harun M. Patel
Publikováno v:
Journal of biomolecular structuredynamics.
Diabetes mellitus (DM) is a group of metabolic disorders characterised by chronic hyperglycaemia. DM is currently one of the top ten causes of death in humans. Chronic hyperglycaemia in DM leads to long-term damage and failure of different organs in
Autor:
Moses Orimoloye Akinjiyan, Nicholas Adeyemi Adewumi, Olabisi Olapade Aiyeku, Babatomiwa Kikiowo, Opeyemi Iwaloye, Olusola Olalekan Elekofehinti, Esther Opeyemi Ariyo, Toyin Mary Fadipe
Publikováno v:
Current Drug Discovery Technologies. 18:554-569
Background: In a bid to come up with effective compounds as inhibitors for antimalarial treatment, we built a library of 2,000 traditional Chinese medicine(TCM)-derived compounds retrieved from TCM Database@Taiwan. Methods: The active sites of both t
Autor:
Azubuike P. Ebokaiwe, Odobi R. Ushang, Tomisin H. Ogunwa, Babatomiwa Kikiowo, Olasiende Olusanya
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 36
This study investigated the protective effect of quercetin against cyclophosphamide-induced immunosuppressive indoleamine 2,3-dioxygenase (IDO) via the mechanism of oxidative-inflammatory stress and behavioral indices. Cyclophosphamide (CYP) was admi
Autor:
Babatomiwa Kikiowo, Niyi S. Adelakun, Adewale J Ogunleye, Taiwo T. Ijatuyi, Wasiu O Alashe, Opeyemi Iwaloye
Publikováno v:
Recent Patents on Anti-Cancer Drug Discovery. 16:273-284
Background: Breast Cancer (BC), a common fatal disease and the deadliest cancer next to lung cancer, is characterized by an abnormal growth of cells in the tissues of the breast. BC chemotherapy is marked by targeting the activities of some receptors
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:1801-1812
Type II Diabetes Mellitus (DM) is caused by insulin resistance in peripheral tissue and impaired insulin secretion through a dysfunction of the pancreatic β-cell. Acarbose is an anti-DM drug, it is effective but its continuous use may lead to undesi