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Autor:
Gareth W. Roberts, Tobias Hartmann, Nobuo Ida, Konrad Beyreuther, David Allsop, Sophie Bieger, Colin L. Masters, Pentti J. Tienari, Carlos G. Dotti, Babara Brühl, Klaus Unsicker
Publikováno v:
Nature Medicine. 3:1016-1020
The Alzheimer amyloid precursor protein (APP) is cleaved by several proteases, the most studied, but still unidentified ones, are those involved in the release of a fragment of APP, the amyloidogenic beta-protein A beta. Proteolysis by gamma-secretas