Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.

Autor: Kenneth C Loh, Weng-In Leong, Morgan E Carlson, Babak Oskouian, Ashok Kumar, Henrik Fyrst, Meng Zhang, Richard L Proia, Eric P Hoffman, Julie D Saba

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37218 (2012)

Sphingosine-1-phosphate (S1P) activates a widely expressed family of G protein-coupled receptors, serves as a muscle trophic factor and activates muscle stem cells called satellite cells (SCs) through unknown mechanisms. Here we show that muscle inju

Externí odkaz: https://doaj.org/article/2f65eb7c06574c7d8f9f1e8aab832f3c

Supplementary Methods, Figures 1-9, Table 1 from Natural Sphingadienes Inhibit Akt-Dependent Signaling and Prevent Intestinal Tumorigenesis

Autor: Julie D. Saba, Andrew R. Lee, Robert Bittman, Hoe Sup Byun, Yaqiong Gong, Padmavathi Bandhuvula, Babak Oskouian, Henrik Fyrst

Supplementary Methods, Figures 1-9, Table 1 from Natural Sphingadienes Inhibit Akt-Dependent Signaling and Prevent Intestinal Tumorigenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330cbbbe5d08204be44d159d77ab5eed
https://doi.org/10.1158/0008-5472.22383575

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

Autor: Jacek Majewski, A. Madrid, Babak Oskouian, Yves Sznajer, Julie Désir, Julie Patat, York Pei, Megan A. Cooper, Weizhen Tan, Elisabet Ars, Monica Furlano, Anne-Sophie Truant, Alain Schmitt, Rainer Wilcken, Won-Il Choi, Navina Kuss, Carolin E. Sadowski, Corinne Antignac, Jillian S. Parboosingh, Vilain Catheline, Marcia C. Willing, Christelle Arrondel, Jia Rao, Vikas R. Dharnidharka, Johanna Magdalena Schmidt, Nicola A.M. Wright, Thomas Giese, Martin Zenker, Brigitte Adams, Franz Schaefer, Richard P. Lifton, Noelle Lachaussée, Merlin Airik, Ingolf Franke, Klaus Schwarz, Julie D. Saba, David Schapiro, Guido Capitani, Seema Hashmi, Howard Riezman, Ronald Biemann, Johann Greil, Vladimir Girik, Anne M Connolly, Shazia Ashraf, Nuria Lloberas, Julian P. Midgley, Denny Schanze, Svjetlana Lovric, Matias Simons, Friedhelm Hildebrandt, Sara Gonçalves, Vincent Vuiblet, Heon Yung Gee, Eugen Widmeier, Tilman Jobst-Schwan, Francois P. Bernier, A. Micheil Innes, Olivier Gribouval, Olivia Boyer, Jung H. Suh, Ryan E. Lamont, Honnappa Srinivas, Daniela A. Braun, Shirlee Shril

Publikováno v: Journal of Clinical Investigation, Vol. 127, no.3, p. 912-928 (2017)
JOURNAL OF CLINICAL INVESTIGATION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Instituto de Salud Carlos III (ISCIII)
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Clinical Investigation, Vol. 127, No 3 (2017) pp. 912-928
Recercat. Dipósit de la Recerca de Catalunya
instname

Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease cases. A mutation in 1 of over 40 monogenic genes can be detected in approximately 30% of individuals with SRNS whose symptoms manifest before 25 years of age. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e691abe1f6479437ce05e74e30dfd7
https://hdl.handle.net/2078.1/204417

Regulation of Sphingosine-1-phosphate Lyase Gene Expression by Members of the GATA Family of Transcription Factors

Autor: Ellyn Shocron, Julie D. Saba, Jane E. Mendel, Michael Lee, Babak Oskouian, Henrik Fyrst

Publikováno v: Journal of Biological Chemistry. 280:18403-18410

Sphingosine-1-phosphate is a bioactive sphingolipid that regulates proliferation, differentiation, migration, and apoptosis. Sphingosine-1-phosphate is irreversibly degraded by the highly conserved enzyme sphingosine-1-phosphate lyase. Recent studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3599de088a1ab87d1d33e8fa13cc1e
https://doi.org/10.1074/jbc.m410928200

YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae

Autor: Babak Oskouian, Julie D. Saba

Publikováno v: Molecular and General Genetics MGG. 261:346-353

In this study, we utilized a genetic approach to identify genes which render yeast cells resistant to cerulenin (Cer), a potent and noncompetitive inhibitor of fatty acid synthase (FAS). Overexpression of the yeast transcription factor Yap1p was foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cd7e3d248f00e851cbde3bb3da63ac
https://doi.org/10.1007/s004380050975