Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

Autor: van Esbroeck ACM; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Janssen APA; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Cognetta AB 3rd; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Ogasawara D; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Shpak G; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands., van der Kroeg M; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands., Kantae V; Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Baggelaar MP; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., de Vrij FMS; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands., Deng H; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Allarà M; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy., Fezza F; Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy., Lin Z; Department of Neuroscience, Erasmus Medical Centre, 3000 CA, Rotterdam, Netherlands., van der Wel T; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Soethoudt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Mock ED; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., den Dulk H; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Baak IL; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Florea BI; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Hendriks G; Toxys B.V., Robert Boyleweg 4, 2333 CG, Leiden, Netherlands., De Petrocellis L; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy., Overkleeft HS; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Hankemeier T; Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., De Zeeuw CI; Department of Neuroscience, Erasmus Medical Centre, 3000 CA, Rotterdam, Netherlands.; Netherlands Institute for Neuroscience, Royal Dutch Academy of Arts and Sciences, 1105 BA, Amsterdam, Netherlands., Di Marzo V; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy., Maccarrone M; European Centre for Brain Research-Institute for Research and Healthcare (IRCCS) Santa Lucia Foundation, Via del Fosso del Fiorano 65, 00143 Rome, Italy.; Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy., Cravatt BF; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Kushner SA; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands. m.van.der.stelt@chem.leidenuniv.nl s.kushner@erasmusmc.nl., van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands. m.van.der.stelt@chem.leidenuniv.nl s.kushner@erasmusmc.nl.

Publikováno v: Science (New York, N.Y.) [Science] 2017 Jun 09; Vol. 356 (6342), pp. 1084-1087.