Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses

Autor: Nazlisadat Seyed Khoei, Mazda Jenab, Neil Murphy, Barbara L. Banbury, Robert Carreras-Torres, Vivian Viallon, Tilman Kühn, Bas Bueno-de-Mesquita, Krasimira Aleksandrova, Amanda J. Cross, Elisabete Weiderpass, Magdalena Stepien, Andrew Bulmer, Anne Tjønneland, Marie-Christine Boutron-Ruault, Gianluca Severi, Franck Carbonnel, Verena Katzke, Heiner Boeing, Manuela M. Bergmann, Antonia Trichopoulou, Anna Karakatsani, Georgia Martimianaki, Domenico Palli, Giovanna Tagliabue, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Susana Merino, Catalina Bonet, Miguel Rodríguez-Barranco, Leire Gil, Maria-Dolores Chirlaque, Eva Ardanaz, Robin Myte, Johan Hultdin, Aurora Perez-Cornago, Dagfinn Aune, Konstantinos K. Tsilidis, Demetrius Albanes, John A. Baron, Sonja I. Berndt, Stéphane Bézieau, Hermann Brenner, Peter T. Campbell, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Michelle Cotterchio, Steven Gallinger, Stephen B. Gruber, Robert W. Haile, Jochen Hampe, Michael Hoffmeister, John L. Hopper, Li Hsu, Jeroen R. Huyghe, Mark A. Jenkins, Amit D. Joshi, Ellen Kampman, Susanna C. Larsson, Loic Le Marchand, Christopher I. Li, Li Li, Annika Lindblom, Noralane M. Lindor, Vicente Martín, Victor Moreno, Polly A. Newcomb, Kenneth Offit, Shuji Ogino, Patrick S. Parfrey, Paul D. P. Pharoah, Gad Rennert, Lori C. Sakoda, Clemens Schafmayer, Stephanie L. Schmit, Robert E. Schoen, Martha L. Slattery, Stephen N. Thibodeau, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Korbinian Weigl, Stephanie J. Weinstein, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Xuehong Zhang, Pietro Ferrari, Gabriele Anton, Annette Peters, Ulrike Peters, Marc J. Gunter, Karl-Heinz Wagner, Heinz Freisling

Publikováno v: BMC Medicine, Vol 18, Iss 1, Pp 1-15 (2020)

Abstract Background Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in

Externí odkaz: https://doaj.org/article/cae0c18ed8fa4e30b56431b7e54f5dd8

'Novel opportunities for NGS-based one health surveillance of foodborne viruses'

Autor: Marion Desdouits, Miranda de Graaf, Sofia Strubbia, Bas B. Oude Munnink, Annelies Kroneman, Françoise S. Le Guyader, Marion P. G. Koopmans

Publikováno v: One Health Outlook, Vol 2, Iss 1, Pp 1-8 (2020)

Abstract Foodborne viral infections rank among the top 5 causes of disease, with noroviruses and hepatitis A causing the greatest burden globally. Contamination of foods by infected food handlers or through environmental pollution are the main source

Externí odkaz: https://doaj.org/article/d8785db4167a4b4b9c4f85999016b981

MERS-CoV in Camels but Not Camel Handlers, Sudan, 2015 and 2017

Autor: Elmoubasher Farag, Reina S. Sikkema, Ahmed A. Mohamedani, Erwin de Bruin, Bas B. Oude Munnink, Felicity Chandler, Robert Kohl, Anne van der Linden, Nisreen M.A. Okba, Bart L. Haagmans, Judith M.A. van den Brand, Asia Mohamed Elhaj, Adam D. Abakar, Bakri Y.M. Nour, Ahmed M. Mohamed, Bader Eldeen Alwaseela, Husna Ahmed, Mohd Mohd Alhajri, Marion Koopmans, Chantal Reusken, Samira Hamid Abd Elrahman

Publikováno v: Emerging Infectious Diseases, Vol 25, Iss 12, Pp 2333-2335 (2019)

We tested samples collected from camels, camel workers, and other animals in Sudan and Qatar in 2015 and 2017 for evidence of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. MERS-CoV antibodies were abundant in Sudan camels, but we

Externí odkaz: https://doaj.org/article/da29e8b792c046308e6622c9a2c8c616

Metavirome Sequencing to Evaluate Norovirus Diversity in Sewage and Related Bioaccumulated Oysters

Autor: Sofia Strubbia, Julien Schaeffer, Bas B. Oude Munnink, Alban Besnard, My V. T. Phan, David F. Nieuwenhuijse, Miranda de Graaf, Claudia M. E. Schapendonk, Candice Wacrenier, Matthew Cotten, Marion P. G. Koopmans, Françoise S. Le Guyader

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

Metagenomic sequencing is a promising method to determine the virus diversity in environmental samples such as sewage or shellfish. However, to identify the short RNA genomes of human enteric viruses among the large diversity of nucleic acids present

Externí odkaz: https://doaj.org/article/caea0b0b1d48499490fb92421d1a2117

Ceramides in tracheal aspirates of preterm infants: Marker for bronchopulmonary dysplasia.

Autor: Esther van Mastrigt, Salomé Zweekhorst, Bas Bol, Jeroen Tibboel, Joost van Rosmalen, Janneke N Samsom, André A Kroon, Johan C de Jongste, Irwin K M Reiss, Martin Post, Mariëlle W Pijnenburg

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0185969 (2018)

In an experimental mouse model we showed that ceramides play a role in the pathogenesis of bronchopulmonary dysplasia (BPD) and are a potential target for therapeutic intervention. We investigated whether ceramides are detectable in tracheal aspirate

Externí odkaz: https://doaj.org/article/0586f3b65d20461b9a22de242c4cd07f