Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.

Autor: Caeiro LD; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA.; Division of Hematology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Nakata Y; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA.; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Borges RL; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA.; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Zha M; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA.; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Garcia-Martinez L; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA.; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Bañuelos CP; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA.; Division of Hematology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Stransky S; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA., Liu T; Department of Computer Science, University of Miami, Coral Gables, Florida 33124, USA., Chan HL; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA.; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Brabson J; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Domínguez D; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain., Zhang Y; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA.; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Lewis PW; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA., Aznar Benitah S; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.; Institució Catalana de Recerca i Estudis Avançats, Barcelona 08010, Spain., Cimmino L; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA., Bilbao D; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA., Sidoli S; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA., Wang Z; Department of Computer Science, University of Miami, Coral Gables, Florida 33124, USA., Verdun RE; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA; lmorey@med.miami.edu rverdun@med.miami.edu.; Division of Hematology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.; Geriatric Research, Education, and Clinical Center, Miami Veterans Affairs Healthcare System, Miami, Florida 33125, USA., Morey L; Sylvester Comprehensive Cancer Center, Biomedical Research Building, Miami, Florida 33136, USA; lmorey@med.miami.edu rverdun@med.miami.edu.; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.

Publikováno v: Genes & development [Genes Dev] 2024 Feb 13; Vol. 38 (1-2), pp. 46-69. Date of Electronic Publication: 2024 Feb 13.

Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia.

Autor: Brabson JP; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Leesang T; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Yap YS; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Wang J; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA., Lam MQ; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Fang B; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Dolgalev I; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA., Barbieri DA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Strippoli V; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Bañuelos CP; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Mohammad S; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Lyon P; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Chaudhry S; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Donich D; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Swirski A; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Roberts E; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Diaz I; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Karl D; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Dos Santos HG; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Shiekhattar R; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Neel BG; Laura and Isaac Perlmutter Cancer Center and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU Grossman School of Medicine, New York, NY 10016, USA., Nimer SD; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Verdun RE; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Bilbao D; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Figueroa ME; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Cimmino L; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address: luisa.cimmino@med.miami.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Jan 31; Vol. 42 (1), pp. 112027. Date of Electronic Publication: 2023 Jan 23.

TbRRM1 knockdown produces abnormal cell morphology and apoptotic-like death in the bloodstream form of T. brucei.

Autor: Níttolo AG; Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia, Gral. San Martín, 1650 Buenos Aires, Argentina. Electronic address: anittolo@iib.unsam.edu.ar., Bañuelos CP; Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia, Gral. San Martín, 1650 Buenos Aires, Argentina. Electronic address: cbanuelos@iib.unsam.edu.ar., Saborit JI; Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia, Gral. San Martín, 1650 Buenos Aires, Argentina. Electronic address: jsaborit@iib.unsam.edu.ar., Tekiel V; Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia, Gral. San Martín, 1650 Buenos Aires, Argentina. Electronic address: valet@iib.unsam.edu.ar., Sánchez DO; Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia, Gral. San Martín, 1650 Buenos Aires, Argentina. Electronic address: dsanchez@unsam.edu.ar., Levy GV; Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia, Gral. San Martín, 1650 Buenos Aires, Argentina. Electronic address: glevy@iib.unsam.edu.ar.

Publikováno v: Molecular and biochemical parasitology [Mol Biochem Parasitol] 2018 Sep; Vol. 224, pp. 1-5. Date of Electronic Publication: 2018 Jul 19.