ASC oligomer favor caspase-1CARD domain recruitment after intracellular potassium efflux

Autor: Compan, Baños Mc, Gómez-Sánchez Ai, Pablo Pelegrín, Ana Tapia-Abellán, Florian I. Schmidt, Fátima Martín-Sánchez

Publikováno v: bioRxiv

Signaling through the inflammasome is important for the inflammatory response. Low concentrations of intracellular K+ are associated with the specific oligomerization and activation of the NLRP3 inflammasome, a type of inflammasome involved in steril

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59a4ae32b7cdfb42af9ab59e4fd22f1

Characterization of Novel Pathogenic Variants Leading to Caspase-8 Cleavage-Resistant RIPK1-Induced Autoinflammatory Syndrome.

Autor: Tapiz I Reula AJ; Department of Internal Medicine, Fundació Althaia, Manresa, Spain., Cochino AV; University of Medicine and Pharmacy 'Carol Davila,', Bucharest, Romania.; National Institute for Mother and Child Health 'Alessandrescu-Rusescu,', Bucharest, Romania., Martins AL; Department of Pediatrics, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal., Angosto-Bazarra D; Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain., de Landazuri IO; Department of Immunology, Hospital Clínic, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Mensa-Vilaró A; Department of Immunology, Hospital Clínic, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Cabral M; Unit of Pediatric Rheumatology, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal., Baroja-Mazo A; Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain., Baños MC; Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain., Lobato-Salinas Z; Department of Pediatrics, Fundació Althaia, Manresa, Spain., Fabregat V; Department of Immunology, Hospital Clínic, Barcelona, Spain., Plaza S; Department of Immunology, Hospital Clínic, Barcelona, Spain., Yagüe J; Department of Immunology, Hospital Clínic, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; School of Medicine, University of Barcelona, Barcelona, Spain., Casals F; Genomics Core Facility, Department of Experimental and Life Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain.; Departament of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Catalonia, Spain., Oliva B; Structural Bioinformatics Lab GRIB-IMIM, Department of Experimental and Life Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain., Figueiredo AE; Unit of Pediatric Immunology, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal., Pelegrín P; Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain.; Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, Murcia, Spain., Aróstegui JI; Department of Immunology, Hospital Clínic, Barcelona, Spain. jiaroste@clinic.cat.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. jiaroste@clinic.cat.; School of Medicine, University of Barcelona, Barcelona, Spain. jiaroste@clinic.cat.

Publikováno v: Journal of clinical immunology [J Clin Immunol] 2022 Oct; Vol. 42 (7), pp. 1421-1432. Date of Electronic Publication: 2022 Jun 18.

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation.

Autor: Tapia-Abellán A; Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.; Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany., Angosto-Bazarra D; Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain., Alarcón-Vila C; Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain., Baños MC; Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain., Hafner-Bratkovič I; Department of Synthetic Biology and Immunology, National Institute of Chemistry, EN-FIST Centre of Excellence, Ljubljana, Slovenia., Oliva B; Laboratory of Structural Bioinformatics (GRIB), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain., Pelegrín P; Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.; Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, 30120 Murcia, Spain.

Publikováno v: Science advances [Sci Adv] 2021 Sep 17; Vol. 7 (38), pp. eabf4468. Date of Electronic Publication: 2021 Sep 15.

COVID-19: hypofractionation in the Radiation Oncology Department during the 'state of alarm': first 100 patients in a private hospital in Spain.

Autor: Larrea L; Radiation Oncology Department, Hospital Vithas Valencia Consuelo, 46007, Spain., López E; Radiation Oncology Department, Hospital Vithas Valencia Consuelo, 46007, Spain., Antonini P; Radiation Oncology Department, Hospital Vithas Valencia Consuelo, 46007, Spain., González V; Radiation Oncology Department, Hospital Vithas Valencia Consuelo, 46007, Spain., Berenguer MÁ; Radiation Oncology Department, Hospital Vithas Valencia Consuelo, 46007, Spain., Baños MC; Radiophysics Department, Hospital Vithas Valencia Consuelo, 46007, Spain., Bea J; Radiophysics Department, Hospital Vithas Valencia Consuelo, 46007, Spain., Domingo J; Radiophysics Department, Hospital Vithas Valencia Consuelo, 46007, Spain.

Publikováno v: Ecancermedicalscience [Ecancermedicalscience] 2020 May 28; Vol. 14, pp. 1052. Date of Electronic Publication: 2020 May 28 (Print Publication: 2020).

Anxiety reduction and emotional self-care using the U-technique in radiology departments.

Autor: Martinez Lorca A; 1 Nuclear Medicine Department, Ramon y Cajal University Hospital, Madrid, Spain., Aguado Romo R; 2 European Institute of Limited Time Psychotherapy (IEPTL), Madrid, Spain., Martinez Lorca M; 3 Department of Psychology, Faculty of Occupational Therapy, Speech therapy and Nursing, University of Castilla-La Mancha, Talavera de la Reina (Toledo), Spain., Zabala Baños MC; 4 Department of Nursing, Physiotherapy and Occupational Therapy, Faculty of Occupational Therapy, Speech therapy and Nursing, University of Castilla-La Mancha, Ciudad Real, Spain.

Publikováno v: The British journal of radiology [Br J Radiol] 2017 Oct; Vol. 90 (1078), pp. 20170173. Date of Electronic Publication: 2017 Jul 27.