Elafibranor: A promising treatment for alcoholic liver disease, metabolic-associated fatty liver disease, and cholestatic liver disease.

Autor: Zhang H; Department of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563006, Guizhou Province, China.; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563006, Guizhou Province, China.; Key Laboratory of Clinical Pharmacy in Zunyi City, Zunyi Medical University, Zunyi 563006, Guizhou Province, China., Dong X; Department of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563006, Guizhou Province, China.; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563006, Guizhou Province, China.; Key Laboratory of Clinical Pharmacy in Zunyi City, Zunyi Medical University, Zunyi 563006, Guizhou Province, China., Zhu L; Department of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563006, Guizhou Province, China.; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563006, Guizhou Province, China.; Key Laboratory of Clinical Pharmacy in Zunyi City, Zunyi Medical University, Zunyi 563006, Guizhou Province, China., Tang FS; Department of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563006, Guizhou Province, China. fstang@vip.163.com.; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563006, Guizhou Province, China.; Key Laboratory of Clinical Pharmacy in Zunyi City, Zunyi Medical University, Zunyi 563006, Guizhou Province, China.

Publikováno v: World journal of gastroenterology [World J Gastroenterol] 2024 Oct 28; Vol. 30 (40), pp. 4393-4398.

The impact of butyrate on group B Streptococcus -induced intestinal barrier disruption.

Autor: Dominguez K; Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA., Pearah AN; Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA., Lindon AK; Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA., Worthington L-AM; Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA., Carter RR; Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA., John-Lewis Edwards N; Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA., Ho TTB; Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.; Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA., Darch SE; Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA., Randis TM; Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.; Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Publikováno v: Infection and immunity [Infect Immun] 2024 Oct 15; Vol. 92 (10), pp. e0020024. Date of Electronic Publication: 2024 Aug 12.

A Sustained-Release Butyrate Tablet Suppresses Ex Vivo T Helper Cell Activation of Osteoarthritis Patients in a Double-Blind Placebo-Controlled Randomized Trial.

Autor: Korsten SGPJ; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.; Tiofarma B.V., 3261 ME Oud-Beijerland, The Netherlands., Hartog M; Department of Research, Sint Maartenskliniek, 6574 NA Ubbergen, The Netherlands.; Department of Rheumatology, Sint Maartenskliniek, 6574 NA Ubbergen, The Netherlands., Berends AJ; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Koenders MI; Department of Rheumatology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Popa CD; Department of Rheumatology, Sint Maartenskliniek, 6574 NA Ubbergen, The Netherlands.; Department of Rheumatology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Vromans H; Tiofarma B.V., 3261 ME Oud-Beijerland, The Netherlands.; Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands., Garssen J; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.; Danone/Nutricia Research B.V., 3584 CT Utrecht, The Netherlands., van de Ende CHM; Department of Research, Sint Maartenskliniek, 6574 NA Ubbergen, The Netherlands.; Department of Rheumatology, Sint Maartenskliniek, 6574 NA Ubbergen, The Netherlands., Vermeiden JPW; Birr Beheer B.V., 3633 AG Vreeland, The Netherlands., Willemsen LEM; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands.

Publikováno v: Nutrients [Nutrients] 2024 Oct 04; Vol. 16 (19). Date of Electronic Publication: 2024 Oct 04.

Update to RIFM fragrance ingredient safety assessment, octyl butyrate, CAS Registry Number 110-39-4.

Autor: Api AM; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Bartlett A; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Belsito D; Member Expert Panel for Fragrance Safety, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA., Botelho D; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Bruze M; Member Expert Panel for Fragrance Safety, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE-20502, Sweden., Bryant-Freidrich A; Member Expert Panel for Fragrance Safety, Pharmaceutical Sciences, Wayne State University, 42 W. Warren Ave., Detroit, MI, 48202, USA., Burton GA Jr; Member Expert Panel for Fragrance Safety, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA., Cancellieri MA; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Chon H; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Dagli ML; Member Expert Panel for Fragrance Safety, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil., Dekant W; Member Expert Panel for Fragrance Safety, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078, Würzburg, Germany., Deodhar C; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Farrell K; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Fryer AD; Member Expert Panel for Fragrance Safety, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA., Jones L; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Joshi K; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Lapczynski A; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Lavelle M; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Lee I; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Moustakas H; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Muldoon J; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Penning TM; Member of Expert Panel for Fragrance Safety, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA., Ritacco G; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Sadekar N; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Schember I; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Schultz TW; Member Expert Panel for Fragrance Safety, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN, 37996- 4500, USA., Siddiqi F; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Sipes IG; Member Expert Panel for Fragrance Safety, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA., Sullivan G; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA. Electronic address: gsullivan@rifm.org., Thakkar Y; Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA., Tokura Y; Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Oct; Vol. 192 Suppl 1, pp. 114993. Date of Electronic Publication: 2024 Sep 11.

Effects of Oral Butyrate on Blood Pressure in Patients With Hypertension: A Randomized, Placebo-Controlled Trial.

Autor: Verhaar BJH; Departments of Vascular Medicine (B.J.H.V., M.W., D.C., M.C., B.-J.H.v.d.B., M.N.), Amsterdam UMC location AMC, the Netherlands.; Department of Internal Medicine-Geriatrics, Amsterdam UMC location VUmc, the Netherlands (B.J.H.V., M.M.).; Amsterdam Cardiovascular Sciences, Diabetes and Metabolism, Atherosclerosis and Ischemic Syndromes, the Netherlands (B.J.H.V., M.W., K.W., E.R., B.-J.H.v.d.B., M.N., M.M.)., Wijdeveld M; Departments of Vascular Medicine (B.J.H.V., M.W., D.C., M.C., B.-J.H.v.d.B., M.N.), Amsterdam UMC location AMC, the Netherlands.; Amsterdam Cardiovascular Sciences, Diabetes and Metabolism, Atherosclerosis and Ischemic Syndromes, the Netherlands (B.J.H.V., M.W., K.W., E.R., B.-J.H.v.d.B., M.N., M.M.).; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Netherlands (M.W., K.W., E.R.)., Wortelboer K; Experimental Vascular Medicine (K.W., E.R., J.H.M.L.), Amsterdam UMC location AMC, the Netherlands.; Amsterdam Cardiovascular Sciences, Diabetes and Metabolism, Atherosclerosis and Ischemic Syndromes, the Netherlands (B.J.H.V., M.W., K.W., E.R., B.-J.H.v.d.B., M.N., M.M.).; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Netherlands (M.W., K.W., E.R.)., Rampanelli E; Experimental Vascular Medicine (K.W., E.R., J.H.M.L.), Amsterdam UMC location AMC, the Netherlands.; Amsterdam Cardiovascular Sciences, Diabetes and Metabolism, Atherosclerosis and Ischemic Syndromes, the Netherlands (B.J.H.V., M.W., K.W., E.R., B.-J.H.v.d.B., M.N., M.M.).; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Netherlands (M.W., K.W., E.R.).; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Cancer Immunology, the Netherlands (E.R.)., Levels JHM; Experimental Vascular Medicine (K.W., E.R., J.H.M.L.), Amsterdam UMC location AMC, the Netherlands., Collard D; Departments of Vascular Medicine (B.J.H.V., M.W., D.C., M.C., B.-J.H.v.d.B., M.N.), Amsterdam UMC location AMC, the Netherlands., Cammenga M; Departments of Vascular Medicine (B.J.H.V., M.W., D.C., M.C., B.-J.H.v.d.B., M.N.), Amsterdam UMC location AMC, the Netherlands., Nageswaran V; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Berlin, Germany (V.N., A.H., U.L.)., Haghikia A; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Berlin, Germany (V.N., A.H., U.L.).; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Germany (A.H., U.L.).; Friede Springe-Cardiovascular Prevention Center at Charité, Charité-Universitätsmedizin Berlin Institute of Health, Germany (A.H., U.L.)., Landmesser U; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Berlin, Germany (V.N., A.H., U.L.).; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Germany (A.H., U.L.).; Friede Springe-Cardiovascular Prevention Center at Charité, Charité-Universitätsmedizin Berlin Institute of Health, Germany (A.H., U.L.)., Li XS; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, OH (X.S.L., J.A.D.)., DiDonato JA; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, OH (X.S.L., J.A.D.)., Hazen SL; Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, OH (S.L.H.)., Garrelds IM; Department of Internal Medicine, Division of Pharmacology, Erasmus MC, Rotterdam, the Netherlands (I.M.G., A.H.J.D.)., Danser AHJ; Department of Internal Medicine, Division of Pharmacology, Erasmus MC, Rotterdam, the Netherlands (I.M.G., A.H.J.D.)., van den Born BH; Departments of Vascular Medicine (B.J.H.V., M.W., D.C., M.C., B.-J.H.v.d.B., M.N.), Amsterdam UMC location AMC, the Netherlands.; Amsterdam Cardiovascular Sciences, Diabetes and Metabolism, Atherosclerosis and Ischemic Syndromes, the Netherlands (B.J.H.V., M.W., K.W., E.R., B.-J.H.v.d.B., M.N., M.M.).; Department of Public and Occupational Medicine, Amsterdam UMC, the Netherlands (B.-J.H.v.d.B.)., Nieuwdorp M; Departments of Vascular Medicine (B.J.H.V., M.W., D.C., M.C., B.-J.H.v.d.B., M.N.), Amsterdam UMC location AMC, the Netherlands.; Amsterdam Cardiovascular Sciences, Diabetes and Metabolism, Atherosclerosis and Ischemic Syndromes, the Netherlands (B.J.H.V., M.W., K.W., E.R., B.-J.H.v.d.B., M.N., M.M.)., Muller M; Department of Internal Medicine-Geriatrics, Amsterdam UMC location VUmc, the Netherlands (B.J.H.V., M.M.).; Amsterdam Cardiovascular Sciences, Diabetes and Metabolism, Atherosclerosis and Ischemic Syndromes, the Netherlands (B.J.H.V., M.W., K.W., E.R., B.-J.H.v.d.B., M.N., M.M.).

Publikováno v: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Oct; Vol. 81 (10), pp. 2124-2136. Date of Electronic Publication: 2024 Jul 22.