Zobrazeno 1 - 10
of 18
pro vyhledávání: '"BUTOPROZINE"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Journal of High Resolution Chromatography. 4:448-453
This paper describes the screening for metabolites of butoprozine, a new anti-anginal drug, in dog bile by means of reverse-phase HPLC. Although it does involve a simple clean-up step to remove a substantial amount of endogenous bile compounds, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31d1cee2d41a6783555d077fa52e1da4
https://doi.org/10.1002/jhrc.1240040905
https://doi.org/10.1002/jhrc.1240040905
Autor:
F. Overzet
Publikováno v:
Journal of high resolution chromatography & chromatography communications, 5(11), 604-615
This article presents a detailed account of the isolation of drug metabolites from bile by reverse-phase HPLC. The systematic approach is illustrated for the metabolism of butoprozine, a new antianginal drug, in the dog. Separation utilizes isocratic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9094084b3df30798b854ad6543f7d4b
https://doi.org/10.1002/jhrc.1240051104
https://doi.org/10.1002/jhrc.1240051104
Publikováno v:
Journal of Chromatography A, 240(1), 190-195. ELSEVIER SCIENCE BV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec92db930116f90472d10cba9c869c0
https://hdl.handle.net/11370/eb9104b4-1683-4c28-9ebb-e0bade0bc1c4
https://hdl.handle.net/11370/eb9104b4-1683-4c28-9ebb-e0bade0bc1c4
Autor:
R. A. De Zeeuw, F. Overzet
Publikováno v:
Xenobiotica. 15:1-10
1. All detectable biliary butoprozine metabolites can be separated with a specially developed analytical approach based on gradient-elution reversed-phase h.p.l.c. without extraction steps.2. The high reproducibility of the h.p.l.c. systems allows pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30275a82c27fac3d514b431ed2578af7
https://doi.org/10.3109/00498258509045329
https://doi.org/10.3109/00498258509045329
Autor:
Ben F. H. Drenth, Rokus A. de Zeeuw
Publikováno v:
Journal of Chromatography A. 191:109-114
A systematic approach to the investigation of metabolic degradation of drugs is presented. Extraction of the biological sample is avoided by direct injection of bile or urine in a reversed-phase high-performance liquid chromatography system. Good sep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85dc7b772c39cef0378fb56acc420eff
https://doi.org/10.1016/s0021-9673(00)86369-4
https://doi.org/10.1016/s0021-9673(00)86369-4
Autor:
B. F. H. Drenth, Ra Dezeeuw
Publikováno v:
International journal of applied radiation and isotopes, 33(8), 681-683
The risk of using only TLC in the radiochemical purity analysis of a radiolabeled drug is shown on the example of butoprozine. The combination of TLC and HPLC gives much better certainty. In case of impurities, HPLC can be used for purification.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73501934049e2fce3cc36566b60a21b
https://doi.org/10.1016/0020-708x(82)90070-9
https://doi.org/10.1016/0020-708x(82)90070-9
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
R.A. de Zeeuw, F. Overzet
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 2(1)
A systematic approach to the recognition, isolation and identification of metabolites of butoprozine in human bile is described as an example of the general approach in this area. Human profiles are compared with those obtained after administration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2c468c15dfa80fdf5a0ef66039b728
https://pubmed.ncbi.nlm.nih.gov/16867761
https://pubmed.ncbi.nlm.nih.gov/16867761