Detection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR Spectroscopy

Autor: Burgess, SG, Grazia Concilio, M, Bayliss, R, Fielding, AJ

Publikováno v: ChemistryOpen

The structure of protein kinases has been extensively studied by protein crystallography. Conformational movement of the kinase activation loop is thought to be crucial for regulation of activity; however, in many cases the position of the activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3b208faba805e22351ec7f0b77b549ef
https://eprints.whiterose.ac.uk/110150/1/Burgess_et_al-2016-ChemistryOpen.pdf

THE USE OF RADIOACTIVE ISOTOPES FOR THE INVESTIGATION OF SEWAGE TREATMENT PLANT.

Autor: GREEN, AF, BURGESS, SG

Publikováno v: ICE Proceedings; Nov1958, Vol. 11 Issue 3, p297-312, 16p

Exploring the dynamics and interactions of the N-myc transactivation domain through solution nuclear magnetic resonance spectroscopy.

Autor: Rejnowicz E; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K., Batchelor M; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K., Leen E; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K., Ahangar MS; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K., Burgess SG; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K., Richards MW; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K., Kalverda AP; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K., Bayliss R; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.

Publikováno v: The Biochemical journal [Biochem J] 2024 Nov 06; Vol. 481 (21), pp. 1535-1556.

Covalent Aurora A regulation by the metabolic integrator coenzyme A.

Autor: Tsuchiya Y; Department of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK., Byrne DP; Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK., Burgess SG; School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Bormann J; Department of Cell and Developmental Biology, University College London, London, WC1E 6BT, UK., Baković J; Department of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK., Huang Y; Department of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK., Zhyvoloup A; Department of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK., Yu BYK; Department of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK., Peak-Chew S; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK., Tran T; Department of Chemistry, University College London, London, WC1E 6BT, UK., Bellany F; Department of Chemistry, University College London, London, WC1E 6BT, UK., Tabor AB; Department of Chemistry, University College London, London, WC1E 6BT, UK., Chan AE; Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, UK., Guruprasad L; School of Chemistry, University of Hyderabad, Hyderabad, 500 046, India., Garifulin O; Department of Cell Signaling, Institute of Molecular Biology and Genetics, Kyiv 143, Ukraine., Filonenko V; Department of Cell Signaling, Institute of Molecular Biology and Genetics, Kyiv 143, Ukraine., Vonderach M; Centre for Proteome Research, Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK., Ferries S; Centre for Proteome Research, Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK., Eyers CE; Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK; Centre for Proteome Research, Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK., Carroll J; Department of Cell and Developmental Biology, University College London, London, WC1E 6BT, UK., Skehel M; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK., Bayliss R; School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: r.w.bayliss@leeds.ac.uk., Eyers PA; Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK. Electronic address: patrick.eyers@liverpool.ac.uk., Gout I; Department of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK; Department of Cell Signaling, Institute of Molecular Biology and Genetics, Kyiv 143, Ukraine. Electronic address: i.gout@ucl.ac.uk.

Publikováno v: Redox biology [Redox Biol] 2020 Jan; Vol. 28, pp. 101318. Date of Electronic Publication: 2019 Sep 05.

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.

Autor: McIntyre PJ; Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester , Leicester, LE1 9HN, United Kingdom., Collins PM; Diamond Light Source, Harwell Science and Innovation Campus , Didcot, OX11 0DE, United Kingdom., Vrzal L; University of Chemistry and Technology , Technická 5, Prague 6 - Dejvice, Prague, 166 28, Czech Republic.; Institute of Organic Chemistry and Biochemistry , Flemingovo nám. 542/2, Prague 6, Prague, 166 10, Czech Republic., Birchall K; LifeArc (Formerly MRC Technology), Stevenage Bioscience Catalyst , Gunnels Wood Road, Stevenage, SG1 2FX, United Kingdom., Arnold LH; LifeArc (Formerly MRC Technology), Stevenage Bioscience Catalyst , Gunnels Wood Road, Stevenage, SG1 2FX, United Kingdom., Mpamhanga C; LifeArc (Formerly MRC Technology), Stevenage Bioscience Catalyst , Gunnels Wood Road, Stevenage, SG1 2FX, United Kingdom., Coombs PJ; LifeArc (Formerly MRC Technology), Stevenage Bioscience Catalyst , Gunnels Wood Road, Stevenage, SG1 2FX, United Kingdom., Burgess SG; Astbury Centre for Structural and Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds , Leeds LS2 9JT, United Kingdom., Richards MW; Astbury Centre for Structural and Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds , Leeds LS2 9JT, United Kingdom., Winter A; Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester , Leicester, LE1 9HN, United Kingdom., Veverka V; Institute of Organic Chemistry and Biochemistry , Flemingovo nám. 542/2, Prague 6, Prague, 166 10, Czech Republic., Delft FV; Diamond Light Source, Harwell Science and Innovation Campus , Didcot, OX11 0DE, United Kingdom.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford , Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom.; Department of Biochemistry, University of Johannesburg , Auckland Park, 2006, South Africa., Merritt A; LifeArc (Formerly MRC Technology), Stevenage Bioscience Catalyst , Gunnels Wood Road, Stevenage, SG1 2FX, United Kingdom., Bayliss R; Astbury Centre for Structural and Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds , Leeds LS2 9JT, United Kingdom.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2017 Nov 17; Vol. 12 (11), pp. 2906-2914. Date of Electronic Publication: 2017 Oct 30.