BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome.

Autor: Miller KA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Cruz Walma DA; Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA., Pinkas DM; Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Department of Biological Sciences, Universidad Loyola Andalucía, Seville, Spain., Tooze RS; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Bufton JC; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Richardson W; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Manning CE; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Hunt AE; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Cros J; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Hartill V; Leeds Institute of Medical Research, University of Leeds, Leeds, UK.; Yorkshire Regional Genetics Service, Leeds Teaching Hospitals NHS Trust, Chapel Allerton Hospital, Leeds, UK., Parker MJ; Sheffield Clinical Genomics Service, Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK., McGowan SJ; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Twigg SRF; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Chalk R; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Staunton D; Department of Biochemistry, University of Oxford, Oxford, UK., Johnson D; Craniofacial Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Wilkie AOM; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Craniofacial Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Bullock AN; Centre for Medicines Discovery, University of Oxford, Oxford, UK alex.bullock@cmd.ox.ac.uk.

Publikováno v: Journal of medical genetics [J Med Genet] 2024 Apr 19; Vol. 61 (5), pp. 490-501. Date of Electronic Publication: 2024 Apr 19.

Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor).

Autor: Zhang L; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China., Chen J; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Yang X; Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China., Shen C; Department of Endocrinology, The First Clinical College, Guangzhou University of Chinese Medicine, Guangdong, China., Huang J; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Zhang D; The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China., Liu N; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Liu C; Department of Endocrinology, The First Clinical College, Guangzhou University of Chinese Medicine, Guangdong, China., Zhong Y; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Chen Y; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Tang K; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Guo J; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Cui T; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Duan S; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Li J; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Huang S; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China., Pan H; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, China., Zhang H; Department of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei, China., Tang X; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China. tangxiaoqiang@scu.edu.cn., Chang Y; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China. changys@tmu.edu.cn., Gao Y; State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China. gaoyong@gzucm.edu.cn.; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, China. gaoyong@gzucm.edu.cn.

Publikováno v: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2024 Jan 24; Vol. 9 (1), pp. 20. Date of Electronic Publication: 2024 Jan 24.

Formononetin enhances the chemosensitivity of triple negative breast cancer via BTB domain and CNC homolog 1-mediated mitophagy pathways.

Autor: Li S; Oncology Department, Dongtai People's Hospital, Dongtai City, Jiangsu Province 224200, China., Zhu L; Oncology Department, Dongtai People's Hospital, Dongtai City, Jiangsu Province 224200, China., He Y; Oncology Department, Dongtai People's Hospital, Dongtai City, Jiangsu Province 224200, China., Sun T; Oncology Department, Dongtai People's Hospital, Dongtai City, Jiangsu Province 224200, China.

Publikováno v: Acta biochimica Polonica [Acta Biochim Pol] 2023 Sep 06; Vol. 70 (3), pp. 533-539.

OsMBTB32, a MATH-BTB domain-containing protein that interacts with OsCUL1s to regulate salt tolerance in rice.

Autor: Ullah U; State Key Laboratory of Crop Stress Biology in Arid Areas, College of Life Sciences, Northwest A&F University, Yangling, 712100, China., Mao W; Shaanxi Changqing National Nature Reserve, Hanzhong, China., Abbas W; National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, 430070, China., Alharthi B; Department of Biology, University College of Al Khurmah, Taif University, Taif, Saudi Arabia., Bhanbhro N; State Key Laboratory of Crop Stress Biology in Arid Areas, College of Life Sciences, Northwest A&F University, Yangling, 712100, China., Xiong M; National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, 430070, China., Gul N; Department of Genetics, Hazara University, Mansehra, KPK, Pakistan., Shalmani A; National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, 430070, China. abdullahshalamni@mail.hzau.edu.cn.

Publikováno v: Functional & integrative genomics [Funct Integr Genomics] 2023 Apr 28; Vol. 23 (2), pp. 139. Date of Electronic Publication: 2023 Apr 28.

BTB domains: A structural view of evolution, multimerization, and protein-protein interactions.

Autor: Bonchuk A; Department of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia., Balagurov K; Department of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia., Georgiev P; Department of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.

Publikováno v: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2023 Feb; Vol. 45 (2), pp. e2200179. Date of Electronic Publication: 2022 Nov 30.