High-Intensity Interval Training Remodels the Proteome and Acetylome of Human Skeletal Muscle

Autor: M Hostrup, AK Lemminger, B Stocks, A Gonzalez-Franquesa, JK Larsen, Prats Quesada J, M Thomassen, BT Weinert, J Bangsbo, AS Deshmukh

Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::743b8e0d40ef8e87a74a263f7f9855ee
https://doi.org/10.1101/2021.02.10.430602

CRISPR-Cas12a nucleases function with structurally engineered crRNAs: SynThetic trAcrRNA.

Autor: Jedrzejczyk DJ; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kongens Lyngby, Denmark., Poulsen LD; Artisan Bio, 363 Centennial Parkway, Suite 310, Louisville, CO, 80027, USA., Mohr M; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kongens Lyngby, Denmark., Damas ND; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kongens Lyngby, Denmark., Schoffelen S; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kongens Lyngby, Denmark., Barghetti A; Artisan Bio, 363 Centennial Parkway, Suite 310, Louisville, CO, 80027, USA., Baumgartner R; Artisan Bio, 363 Centennial Parkway, Suite 310, Louisville, CO, 80027, USA., Weinert BT; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kongens Lyngby, Denmark., Warnecke T; Artisan Bio, 363 Centennial Parkway, Suite 310, Louisville, CO, 80027, USA. tanya@artisancells.com., Gill RT; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800, Kongens Lyngby, Denmark. rtg@artisancells.com.; Artisan Bio, 363 Centennial Parkway, Suite 310, Louisville, CO, 80027, USA. rtg@artisancells.com.

Publikováno v: Scientific reports [Sci Rep] 2022 Jul 16; Vol. 12 (1), pp. 12193. Date of Electronic Publication: 2022 Jul 16.

Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter.

Autor: Lopez DV; The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Al-Jaberi FAH; The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Damas ND; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Weinert BT; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Pus U; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark., Torres-Rusillo S; The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Woetmann A; The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ødum N; The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bonefeld CM; The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kongsbak-Wismann M; The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Geisler C; The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Aug 02; Vol. 12, pp. 715059. Date of Electronic Publication: 2021 Aug 02 (Print Publication: 2021).

Author Correction: Functions and mechanisms of non-histone protein acetylation.

Autor: Narita T; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Weinert BT; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Choudhary C; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. chuna.choudhary@cpr.ku.dk.

Publikováno v: Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2019 Aug; Vol. 20 (8), pp. 508.

Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation.

Autor: Hansen BK; Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark., Gupta R; Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark., Baldus L; Institute of Biochemistry, Synthetic and Structural Biochemistry, University of Greifswald, Felix-Hausdorff-Str. 4, Greifswald, 17487, Germany.; Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, CECAD, University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany., Lyon D; Disease Systems Biology Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark., Narita T; Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark., Lammers M; Institute of Biochemistry, Synthetic and Structural Biochemistry, University of Greifswald, Felix-Hausdorff-Str. 4, Greifswald, 17487, Germany.; Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, CECAD, University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany., Choudhary C; Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark. chuna.choudhary@cpr.ku.dk., Weinert BT; Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark. brian.weinert@gmail.com.

Publikováno v: Nature communications [Nat Commun] 2019 Mar 05; Vol. 10 (1), pp. 1055. Date of Electronic Publication: 2019 Mar 05.