Zobrazeno 1 - 10
of 47
pro vyhledávání: '"BRYAN S. FINKLE"'
Autor:
Bryan S. Finkle
Publikováno v:
Journal of Chemical Technology & Biotechnology. 43:313-327
There is a considerable history of natural and biosynthetic biologics used as drugs, and their development, evaluation, and regulation serves as a useful guide to the risks and safety of recombinant drugs in the context of medicine. These agents are
Autor:
Bryan S. Finkle
Publikováno v:
Analytical Chemistry. 54:433A-447A
Publikováno v:
Journal of Chromatographic Science. 21:201-204
Several problems associated with the gas chromatographic determination of DPX and NDPX are discussed and an improved method for their extraction and quantification is described. The method involves two separate extractions, one for DPX with SKF 525A
Publikováno v:
Clinical Chemistry. 28:457-461
A quantitative "high-pressure" liquid-chromatographic assay for tricyclic antidepressant drugs in plasma or serum is described in which amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and desmethyldoxepin are separated with a 10-micro
Publikováno v:
Journal of Analytical Toxicology. 3:143-149
a-Acatylmethedol (LAAM) Is a relatively new drug designed for therapeutic use In the treatment of heroin de- pendence. Currently, It Is undergoing Phase III clinical trials In the United States and Is, therefore, available for human use only on a lim
Publikováno v:
Journal of Chromatographic Science. 12:304-328
Determination of Methaqualone and Its Major Metabolite in Plasma and Saliva After Single Oral Doses*
Publikováno v:
Journal of Analytical Toxicology. 4:114-118
A gas liquid chromatographic procedure for the determination of methaqualone and metabolite l (2-methyl-3(2-hydroxymethylphenyl)-4-(4H)-quinazoline) in plasma and saliva is described. The method requires 1.0 mL of sample and involves internal standar
Publikováno v:
Journal of Analytical Toxicology. 6:153-156
A rapid and simple method is described for the separation of quinidine (Q), its metabolites 3-hydroxyquinidine (30HQ) and 2'oxoquinidinone (QD) as well as the quinidine salt contaminant, dihydroquinidine (DHQ) in plasma by high pressure liquid chroma
Publikováno v:
Life Sciences. 30:307-312
Levo-alpha-acetylmethadol (LAAM, 0.2 or 2.0 mg/kg/day) was orally administered to female Sprague-Dawley rats for one month prior to and throughout pregnancy. The rats were killed on the 18th day of gestation along with a group of 18-day pregnant fema
Publikováno v:
Journal of Chromatographic Science. 17:64-74
1-alpha-acetylmethadol (LAAM) is a new drug under development for the treatment of heroin dependence. A new analytical method applicable to the accurate biodispositional study of the drug and its metabolities is described and critically discussed in