Zobrazeno 1 - 10
of 1 228
pro vyhledávání: '"BRUCE S. McEWEN"'
Autor:
Salvatore G. Caradonna, Nathan R. Einhorn, Vikram Saudagar, Huzefa Khalil, Gordon H. Petty, Axel Lihagen, Claire LeFloch, Francis S. Lee, Huda Akil, Alessandro Guidotti, Bruce S. McEwen, Eleonora Gatta, Jordan Marrocco
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The genomic effects of circulating glucocorticoids are particularly relevant in cortico-limbic structures, which express a high concentration of steroid hormone receptors. To date, no studies have investigated genomic differences in hippocam
Externí odkaz:
https://doaj.org/article/946390fb10404143a63c4fcbe9a595c5
Autor:
Sanoara Mazid, Elizabeth M. Waters, Chloe Lopez-Lee, Renata Poultan Kamakura, Batsheva R. Rubin, Ellis R. Levin, Bruce S. McEwen, Teresa A. Milner
Publikováno v:
Biology, Vol 12, Iss 4, p 632 (2023)
Estrogens via estrogen receptor alpha (ERα) genomic and nongenomic signaling can influence plasticity processes in numerous brain regions. Using mice that express nuclear only ERα (NOER) or membrane only ERα (MOER), this study examined the effect
Externí odkaz:
https://doaj.org/article/9084af1be21841c9b822cedb159ae1fa
Autor:
Alexandra Dolgetta, Megan Johnson, Kate Fruitman, Luke Siegel, Yan Zhou, Bruce S. McEwen, Mary Jeanne Kreek, Teresa A. Milner
Publikováno v:
Neurobiology of Stress, Vol 17, Iss , Pp 100431- (2022)
Glutamate receptors have a key role in the neurobiology of opioid addiction. Using electron microscopic immunocytochemical methods, this project elucidates how sex and chronic immobilization stress (CIS) impact the redistribution of GluN1 and GluA1 w
Externí odkaz:
https://doaj.org/article/3b28b44451fd4c55ade536f5155b4a41
Autor:
Batsheva R. Rubin, Megan A. Johnson, Jared M. Berman, Ellen Goldstein, Vera Pertsovskaya, Yan Zhou, Natalina H. Contoreggi, Andreina G. Dyer, Jason D. Gray, Elizabeth M. Waters, Bruce S. McEwen, Mary Jeanne Kreek, Teresa A. Milner
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100236- (2020)
Following oxycodone (Oxy) conditioned place preference (CPP), delta opioid receptors (DORs) differentially redistribute in hippocampal CA3 pyramidal cells in female and male rats in a manner that would promote plasticity and opioid-associative learni
Externí odkaz:
https://doaj.org/article/5dbdbc6efce8429e9a258232eb7e0889
Autor:
Matthew Randesi, Yan Zhou, Sanoara Mazid, Shannon C. Odell, Jason D. Gray, J. Correa da Rosa, Bruce S. McEwen, Teresa A. Milner, Mary Jeanne Kreek
Publikováno v:
Neurobiology of Stress, Vol 8, Iss , Pp 33-41 (2018)
Opioid peptides and their receptors re-organize within hippocampal neurons of female, but not male, rats following chronic immobilization stress (CIS) in a manner that promotes drug-related learning. This study was conducted to determine if there are
Externí odkaz:
https://doaj.org/article/bee4934bb04d4c8596335143280989ce
Autor:
Jordan Marrocco, Gordon H. Petty, Mariel B. Ríos, Jason D. Gray, Joshua F. Kogan, Elizabeth M. Waters, Eric F. Schmidt, Francis S. Lee, Bruce S. McEwen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Animals’ response to acute stress is known to be influenced by sex and genetics. Here the authors performed RNA-seq on actively translated mRNAs in hippocampal CA3 neurons in mice, and document the effects of sex and genotype (i.e., BDNF Val66Met)
Externí odkaz:
https://doaj.org/article/801b66d7a1be477d9f8b4a7aaf7b868e
Autor:
Jordan Marrocco, Jason D. Gray, Joshua F. Kogan, Nathan R. Einhorn, Emma M. O’Cinneide, Todd G. Rubin, Thomas S. Carroll, Eric F. Schmidt, Bruce S. McEwen
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Early life experiences program brain structure and function and contribute to behavioral endophenotypes in adulthood. Epigenetic control of gene expression by those experiences affect discrete brain regions involved in mood, cognitive function and re
Externí odkaz:
https://doaj.org/article/7d821a3e446f48289924a8d3432e86a2
Autor:
Bruce S. McEwen
Publikováno v:
Chronic Stress, Vol 3 (2019)
Cortisol has many roles not only in mediating the response to stress but also in the circadian rhythm, and it does so by both genomic and nongenomic cellular and molecular mechanisms. Yet, it is common to associate cortisol only with stress and, in p
Externí odkaz:
https://doaj.org/article/861635d27838451f905ab68769a13025
Autor:
Sanoara Mazid, Baila S. Hall, Shannon C. Odell, Khalifa Stafford, Andreina D. Dyer, Tracey A. Van Kempen, Jane Selegean, Bruce S. McEwen, Elizabeth M. Waters, Teresa A. Milner
Publikováno v:
Neurobiology of Stress, Vol 5, Iss C, Pp 37-53 (2016)
Drug addiction requires associative learning processes that critically involve hippocampal circuits, including the opioid system. We recently found that acute and chronic stress, important regulators of addictive processes, affect hippocampal opioid
Externí odkaz:
https://doaj.org/article/4aee1378c2bf44a6b8f7ffb4aa090ecd
Autor:
Thomas E. Chan, Yael S. Grossman, Erik B. Bloss, William G. Janssen, Wendy Lou, Bruce S. McEwen, Dani Dumitriu, John H. Morrison
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Repeated exposure to stressors is known to produce large-scale remodeling of neurons within the prefrontal cortex (PFC). Recent work suggests stress-related forms of structural plasticity can interact with aging to drive distinct patterns of pyramida
Externí odkaz:
https://doaj.org/article/549d4ccd60944685b2e623a5e59e7156