Zobrazeno 1 - 10
of 253
pro vyhledávání: '"BRUCE K CASSELS"'
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209804 (2019)
The last fifteen years have seen the emergence and overflow into the drug scene of "superpotent" N-benzylated phenethylamines belonging to the "NBOMe" series, accompanied by numerous research articles. Although N-benzyl substitution of 5-methoxytrypt
Externí odkaz:
https://doaj.org/article/9f4bcf336efd4288842c963454b21e34
Autor:
Pabla Aguirre, Natalia P Mena, Carlos M Carrasco, Yorka Muñoz, Patricio Pérez-Henríquez, Rodrigo A Morales, Bruce K Cassels, Carolina Méndez-Gálvez, Olimpo García-Beltrán, Christian González-Billault, Marco T Núñez
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144848 (2015)
Neuronal death in Parkinson's disease (PD) is often preceded by axodendritic tree retraction and loss of neuronal functionality. The presence of non-functional but live neurons opens therapeutic possibilities to recover functionality before clinical
Externí odkaz:
https://doaj.org/article/07e3dcd9b356406682ba92db1457d413
Publikováno v:
Biological Research, Vol 39, Iss 1, Pp 199-201 (2006)
There is increasing evidence that accumulation of redox-active iron in mitochondria leads to oxidative damage and contributes to various neurodegenerative diseases, such as Friedreich's ataxia and Parkinson's disease. In this work, we examined the ex
Externí odkaz:
https://doaj.org/article/937e265f6f264e31a60ed78bea8104fd
Publikováno v:
Journal of Chemical Information and Modeling. 61:5001-5012
The binding of C-4-halogenated 1-(4-X-2,5-dimethoxyphenyl)-2-aminopropane (DOX) serotonin agonist psychedelics at all three 5-HT2 receptor subtypes is up to two orders of magnitude stronger for X = Cl, Br, or I (but not F) than when C-4 bears a hydro
Autor:
Edwin G. Pérez, Oriel A Sánchez-Velasco, Daniel A A Araya-Santelices, Jorge Saavedra-Olavarría, Patricio Hermosilla-Ibáñez, Bruce K. Cassels
Publikováno v:
Journal of Natural Products. 84:1985-1992
N-Arylcytisine derivatives are quite rare. We report here a practical methodology to obtain these compounds. Using the copper-catalyzed Chan-Lam coupling, we synthesized new N-arylcytisine derivatives at room temperature, in air and using inexpensive
Autor:
Osvaldo Yañez, Lina María Ruiz, Edison Osorio, Bruce K. Cassels, Carlos Areche, Olimpo García-Beltrán, Alejandro Vásquez-Espinal, William Tiznado
Publikováno v:
New Journal of Chemistry. 45:590-596
Previous experimental results on the free radical-scavenging properties of boldine, one of the most potent natural antioxidants, suggested that the benzylic hydrogen, neighboring a nitrogen lone electron pair, might be the key to its protective and a
Autor:
Douglas J Matthies, María Isabel Loza, José Brea, Bruce K. Cassels, Thirumal Yempala, Gerald Zapata-Torres
Publikováno v:
ACS Omega, Vol 5, Iss 5, Pp 2260-2266 (2020)
ACS Omega
ACS Omega
The human 5-HT2 receptor subtypes have high sequence identity in their orthosteric ligand-binding domain, and many agonists are poorly selective between the 5-HT2A and 5-HT2C subtypes. Nevertheless, their activation is associated with different pharm
Publikováno v:
Synthetic Communications. 50:438-445
The 2,3,4,5-tetrahydro-1H-benzo[2,3]benzofuro[6,5-b]azepine skeleton was built starting from dibenzofuran via 3-aminodibenzofuran, creating the 5-methylene-substituted azepine ring by an intramolec...
Publikováno v:
Journal of chemical information and modeling. 61(10)
The binding of C-4-halogenated 1-(4-X-2,5-dimethoxyphenyl)-2-aminopropane (DOX) serotonin agonist psychedelics at all three 5-HT
Autor:
Oriel A, Sánchez-Velasco, Jorge, Saavedra-Olavarría, Daniel A A, Araya-Santelices, Patricio, Hermosilla-Ibáñez, Bruce K, Cassels, Edwin G, Pérez
Publikováno v:
Journal of natural products. 84(7)