Zobrazeno 1 - 10
of 243
pro vyhledávání: '"BROXTERMAN, HJ"'
Publikováno v:
Biochemistry. 37:2243-2250
Multidrug resistance protein (MRP) and P-glycoprotein (Pgp) are both members of the superfamily of ATP binding cassette plasma membrane drug transport proteins, which may be partly responsible for multidrug resistance of tumor cells. Although MRP has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e3870437b9a06cd317210483c6700e
https://doi.org/10.1021/bi9718043
https://doi.org/10.1021/bi9718043
Autor:
de Groot, FMH, Broxterman, HJ, Adams, HPHM, van Vliet, A, Tesser, GI, Elderkamp, YW, Leegte - Schraa, Astrid, Kok, RJ, Molema, G, Pinedo, HM, Scheeren, H.W.
Publikováno v:
Molecular cancer therapeutics, 1(11), 901-911. AMER ASSOC CANCER RESEARCH
The design, synthesis, and initial biological evaluation of a doxorubicin prodrug that contains a dual tumor specific moiety, which allows enhanced tumor recognition potential, is reported. Both a tumor-specific recognition site and a tumor selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::06e75d1329c6358117329e6bb1319ee3
https://research.rug.nl/en/publications/6f80cc64-a768-44c6-b1e8-4dd27a9c7560
https://research.rug.nl/en/publications/6f80cc64-a768-44c6-b1e8-4dd27a9c7560
Autor:
SLOVAK, ML, HO, JP, COLE, SPC, DEELEY, RG, GREENBERGER, L, DEVRIES, EGE, BROXTERMAN, HJ, SCHEFFER, GL, SCHEPER, RJ
Publikováno v:
Cancer Research, 55(19), 4214-4219. AMER ASSOC CANCER RESEARCH
A cDNA encoding the novel drug resistance gene, LRP (originally termed lung resistance-related protein), was isolated from HT1080/DR4, a 220-fold doxorubicin-resistant human fibrosarcoma cell line which displays a multidrug resistance phenotype and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::d17c9862590881d9a8afab1c057a7697
https://research.rug.nl/en/publications/01423065-ccbb-4c54-9ef5-134970ab91d2
https://research.rug.nl/en/publications/01423065-ccbb-4c54-9ef5-134970ab91d2
Autor:
VERSANTVOORT, CHM, WITHOFF, S, BROXTERMAN, HJ, KUIPER, CM, SCHEPER, RJ, MULDER, NH, DEVRIES, EGE
Publikováno v:
International Journal of Cancer, 61(3), 375-380. Wiley
Previous studies have shown that the in vitro-selected adriamycin-resistant human small-cell lung-carcinoma cell line GLC(4)A-ADR(150) displays multidrug resistance as the result of 3-fold decreased DNA-topoisomerase II (topo II) activity and a 6-fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::67384834503055786a76621559919948
https://research.rug.nl/en/publications/2ef71b57-fcc8-470a-9554-befaef0842e9
https://research.rug.nl/en/publications/2ef71b57-fcc8-470a-9554-befaef0842e9
Publikováno v:
"Drug transport in antimicrobial and anticancer chemotherapy", 21-62
STARTPAGE=21;ENDPAGE=62;TITLE=In: "Drug transport in antimicrobial and anticancer chemotherapy"
STARTPAGE=21;ENDPAGE=62;TITLE=In: "Drug transport in antimicrobial and anticancer chemotherapy"
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::43d3aef7b53638da7352ee551b66a4eb
https://research.vumc.nl/en/publications/21025258-b4ce-455e-ac00-75dd8188174f
https://research.vumc.nl/en/publications/21025258-b4ce-455e-ac00-75dd8188174f
Autor:
ZAMAN, GJR, VERSANTVOORT, CHM, SMIT, JJM, EIJDEMS, EWHM, DEHAAS, M, SMITH, AJ, BROXTERMAN, HJ, MULDER, NH, DEVRIES, EGE, BAAS, F, BORST, P
Publikováno v:
Cancer Research, 53(8), 1747-1750. AMER ASSOC CANCER RESEARCH
Human cells can become multidrug resistant (MDR) by an increase in the activity of the MDR1 P-glycoprotein or by other, as vet unknown mechanisms, referred to as non-P-glycoprotein mediated MDR (non-Pgp MDR). S. P. C. Cole et al. [Science (Washington
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::9bb4b2a107af946c25c51487675dce54
https://research.rug.nl/en/publications/704ebabe-6983-4e19-ad8d-b32fdc103995
https://research.rug.nl/en/publications/704ebabe-6983-4e19-ad8d-b32fdc103995
Autor:
SCHEPER, RJ, BROXTERMAN, HJ, SCHEFFER, GL, KAAIJK, P, DALTON, WS, VANHEIJNINGEN, THM, VANKALKEN, CK, SLOVAK, ML, DEVRIES, EGE, VANDERVALK, P, MEIJER, CJLM, PINEDO, HM
Publikováno v:
Cancer Research, 53(7), 1475-1479. AMER ASSOC CANCER RESEARCH
A M(r)110,000 protein (p110) is overexpressed in P-glycoprotein-negative multidrug-resistant tumor cell lines of different histogenetic origins. These cell lines show an ATP-dependent drug accumulation defect, suggesting the presence of drug transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::6ed24b8d13e1d362e258f4b30885ddf3
https://research.rug.nl/en/publications/7b056c8f-0162-42fe-92c5-fa28dc78375a
https://research.rug.nl/en/publications/7b056c8f-0162-42fe-92c5-fa28dc78375a
Autor:
VERSANTVOORT, CHM, BROXTERMAN, HJ, PINEDO, HM, DEVRIES, EGE, FELLER, N, KUIPER, CM, LANKELMA, J
Publikováno v:
Cancer Research, 52(1), 17-23. AMER ASSOC CANCER RESEARCH
Mechanisms contributing to reduced cytotoxic drug accumulation were studied in two multidrug-resistant (MDR) human lung cancer cell lines without P-glycoprotein expression. In these (non-small cell) SW-1573/ 2R120 and (small cell) GLC4/ADR MDR cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::00d1ee1da6924422f147cdf863d50463
https://research.rug.nl/en/publications/b3a4b92e-7b24-4be8-aef0-a8d708b83b14
https://research.rug.nl/en/publications/b3a4b92e-7b24-4be8-aef0-a8d708b83b14
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Akademický článek
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