Výsledky vyhledávání

Human adrenocorticotropin-secreting pituitary adenomas show frequent loss of heterozygosity at the glucocorticoid receptor gene locus

Autor: HUIZENGA NA, KOPER JW, CLAYTON RN, FARELL W, VAN DER LELY AJ, BRINKMAN AO, DE JONG FH, LAMBERTS SW, DE LANGE, Pieter

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 83(3), 917-921. Endocrine Society

Corticotropinomas are characterized by a relative resistance to the negative feedback action of cortisol on ACTH secretion. In this respect there is a similarity with the clinical syndrome of cortisol resistance. As cortisol resistance can be caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136105454e95d1f78d8c7b21c87e4483
https://hdl.handle.net/1765/8792

Zobrazit plný text záznamu

Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells

Autor: DE LANGE, Pieter, SEGEREN CM, KOPER JW, WIEMER E, SONNEVELD P, BRINKMAN AO, DE JONG FH, LAMBERTS SW

Glucocorticoids play an important role in the treatment of a number of hematological malignancies, such as multiple myeloma. The effects of glucocorticoids are mediated through the glucocorticoid receptor α, the abundance of which can be modulated b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3977::9d3944b5bf4dd2fb956d06dc4ebb1688
http://hdl.handle.net/11591/181899

Zobrazit plný text záznamu

A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo

Autor: HUIZENGA NA, KOPER JW, POLS HAP, STOLK RP, BURGER H, GROBBEE DE, BRINKMAN AO, DE JOING FH, LAMBERTS SW, DE LANGE, Pieter

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 83(1), 144-151. Endocrine Society
Journal of Clinical Endocrinology and Metabolism, 83(1), 144-151. ENDOCRINE SOC

We investigated whether a polymorphism at nucleotide position 1220, resulting in an asparagine-to-serine change at codon 363 in the glucocorticoid receptor (GR) gene is associated with an altered sensitivity to glucocorticoids. In a group of 216 elde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358f930eb6c6485123a996e56d6cd140
http://hdl.handle.net/11591/197252

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Differential Hormone-Dependent Transcriptional Activation and -Repression by Naturally Occurring Human Glucocorticoid Receptor Variants

Autor: Steven W. J. Lamberts, Frank H. de Jong, George P. Chrousos, Pieter de Lange, Jan W. Koper, Albert O. Brinkmann, Nannette A. T. M. Huizenga, Michael Karl

Publikováno v: Molecular Endocrinology. 11:1156-1164

The molecular mechanisms underlying primary glucocorticoid resistance or hypersensitivity are not well understood. Using transfected COS-1 cells as a model system, we studied gene regulation by naturally occurring mutants of the glucocorticoid recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9541a70dd63ee1d7dc833d7efbb26f5
https://doi.org/10.1210/mend.11.8.9949

Zobrazit plný text záznamu

Natural variants of the ß isoform of the human glucocorticoid receptor do not alter sensitivity to glucocorticoids

Autor: Albert O. Brinkmann, Frank H. de Jong, Steven W. J. Lamberts, Pieter de Lange, Jan W. Koper

Publikováno v: Molecular and Cellular Endocrinology, 153, 163-168. Elsevier Ireland Ltd

The beta isoform of the human glucocorticoid receptor, hGRbeta, is a product of alternative splicing of the hGR gene. The physiological function of this isoform is unknown up to now. Recent data are contradictory in that they either favor or argue ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b3dc039e7a5143ebddf505ff974076
https://pure.eur.nl/en/publications/1debdc68-88aa-4c05-a360-8d9fc508b414

Zobrazit plný text záznamu

Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance

Autor: Albert O. Brinkmann, FH deJong, Hap Pols, S. W. J. Lamberts, Natm Huizenga, Ronald P. Stolk, Jan W. Koper, P deLange, D. E. Grobbee, Michael Karl, G. J. Molijn

Publikováno v: Human Genetics, 663-668. Springer-Verlag
ISSUE=99;STARTPAGE=663;ENDPAGE=668;ISSN=0340-6717;TITLE=Human Genetics
HUMAN GENETICS, 99(5), 663-668. SPRINGER

Glucocorticoid resistance due to mutations in the gene for the glucocorticoid receptor has been suggested to be more common than is thought at present, owing to the relative mildness of its symptoms and the difficulty of its diagnosis. To investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804032137343741e59b1a35cc0fa7855
https://pure.eur.nl/en/publications/8255ef95-2ba7-45e9-9cbb-9d2d88a8cccd

Zobrazit plný text záznamu

Akademický článek

Testicular estradiol receptors in the rat.

Autor: Mulder E, van Beurden-Lamers WM, De Boer W, Brinkman AO, van der Molen HJ

Publikováno v: Current topics in molecular endocrinology [Curr Top Mol Endocrinol] 1974; Vol. 1, pp. 343-55.

Zobrazit plný text záznamu

Akademický článek

Modulation of steroidogenic activities in testis Leydig cells.

Autor: Rommerts FF, Brinkman AO

Publikováno v: Molecular and cellular endocrinology [Mol Cell Endocrinol] 1981 Jan; Vol. 21 (1), pp. 15-28.

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání