Zobrazeno 1 - 10
of 1 552
pro vyhledávání: '"BRG1"'
Autor:
Venkataragavan Chandrasekaran, Karin M. E. Andersson, Malin Erlandsson, Shuxiang Li, Torbjörn Nur Olsson, Maria-Jose Garcia-Bonete, Eric Malmhäll-Bah, Pegah Johansson, Gergely Katona, Maria I. Bokarewa
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract Background Bivalent regions of chromatin (BvCR) are characterized by trimethylated lysine 4 (H3K4me3) and lysine 27 on histone H3 (H3K27me3) deposition which aid gene expression control during cell differentiation. The role of BvCR in post-t
Externí odkaz:
https://doaj.org/article/607961b2191a4331a9a9f4b3e13e88db
Autor:
Mariano Lombardi, Marianna D'Ercole, Valeria Midolo De Luca, Matteo Chiari, Lorenzo Spaggiari, Luca Bertolaccini
Publikováno v:
Heliyon, Vol 11, Iss 1, Pp e41128- (2025)
This case report explores the therapeutic impact of SMARCA4 loss in a 63-year-old female patient with a history of smoking, hypertension, hypercholesterolemia, and prior surgeries for breast and pancreatic carcinomas, who presented with a new pulmona
Externí odkaz:
https://doaj.org/article/e84d6266df4e4959aafa6129fefb9782
Autor:
Tao Ban, Xianhui Dong, Ziyue Ma, Jing Jin, Jing Li, Yunfeng Cui, Yuyang Fu, Yongzhen Wang, Yadong Xue, Tingting Tong, Kai Zhang, Yuxuan Han, Meimei Shen, Yu Zhao, Ling Zhao, Lingzhao Xiong, Hongzhao Lv, Yang Liu, Rong Huo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundTransient Receptor Potential Melastatin 4 (TRPM4), a non-selective cation channel, plays a critical role in cardiac conduction abnormalities. Brg1, an ATP-dependent chromatin remodeler, is essential for regulating gene expression in both he
Externí odkaz:
https://doaj.org/article/77b53d929f9249b19feb90c007e90e6a
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumors worldwide. Brahma-related gene 1 (BRG1), as a catalytic ATPase, is a major regulator of gene expression and is known to mutate and overexpress in HCC. The purpose of this study
Externí odkaz:
https://doaj.org/article/7aa4ee670d57461a88760d480ae08db8
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 6, Pp 469-474 (2024)
ObjectiveTo investigate the clinicopathological features, immunophenotype, diagnosis and treatment of SMARCA4 (BRG1)-deficient carcinoma. MethodsClinical data of 11 patients with SMARCA4 (BRG1)-deficient cancer were collected. The morphologic and imm
Externí odkaz:
https://doaj.org/article/ecd39f02a6cc49c4b22db24bb641099e
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Background SMARCA4, as one of the subunits of the SWI/SNF chromatin remodeling complex, drives SMARCA4-deficient tumors. Gastric SMARCA4-deficient tumors may include gastric SMARCA4-deficient carcinoma and gastric SMARCA4-deficient undiffere
Externí odkaz:
https://doaj.org/article/2ded673f49734bd9a3b6443294b9062c
Publikováno v:
Türk Patoloji Dergisi, Vol 40, Iss 2, Pp 128-133 (2024)
Objective: SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a highly malignant neoplasm with an undifferentiated or rhabdoid phenotype, posing a diagnostic challenge. This case report aims to create awareness about this rare neoplasm while de
Externí odkaz:
https://doaj.org/article/4462016a8f3a4270bf0257aac494ba76
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Autor:
Yulin Yuan, Youhong Fan, Li Huang, Han Lu, Bowen Tan, Chloe Ramirez, Chao Xia, Xiangli Niu, Sixue Chen, Mingjun Gao, Cankui Zhang, Yongsheng Liu, Fangming Xiao
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract In plants, vegetative growth is controlled by synergistic and/or antagonistic effects of many regulatory factors. Here, the authors demonstrate that the ubiquitin ligase seven in absentia1 (SINA1) mammalian BTF2‐like transcription factors,
Externí odkaz:
https://doaj.org/article/99ab62035a1e4289a2db0f561b456cda
Autor:
Yijian, Lu, Weihan, Sun, Lin, Ye, Heng, Zhang, Yu, Wang, Lin, Song, Shuo, Miao, Mengyang, Li ⁎, Jianxun, Wang ⁎
Publikováno v:
In Cellular Signalling August 2024 120