Zobrazeno 1 - 10
of 4 917
pro vyhledávání: '"BRD4"'
Autor:
Songnan Sui, Mengjun Zhong, Shuxin Zhong, Xueting Peng, Lipeng Mao, Cunte Chen, Chengwu Zeng, Oscar Junhong Luo, Yangqiu Li
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Background Exhaustion is a key factor that influences the efficacy of chimeric antigen receptor T (CAR-T) cells. Our previous study demonstrated that a bromodomain protein 4 (BRD4) inhibitor can revise the phenotype and function of exhausted
Externí odkaz:
https://doaj.org/article/4ffb6b26b2d74680b653b6d87757a4c9
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background iPSC reprogramming technology exhibits significant promise in the realms of clinical therapeutics, disease modeling, pharmaceutical drug discovery, and various other applications. However, the extensive utilization of this technol
Externí odkaz:
https://doaj.org/article/741d377c95c5444086207e38024cbde8
Publikováno v:
Journal of Advanced Research, Vol 63, Iss , Pp 207-218 (2024)
Background: Aging, a complex and profound journey, leads us through a labyrinth of physiological and pathological transformations, rendering us increasingly susceptible to aging-related diseases. Emerging investigations have unveiled the function of
Externí odkaz:
https://doaj.org/article/036944c09f8e4695852137b8a918b19d
Autor:
Qun Wei, Cailing Gan, Meng Sun, Yuting Xie, Hongyao Liu, Taixiong Xue, Conghui Deng, Chunheng Mo, Tinghong Ye
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-30 (2024)
Abstract Fibrosis is an excessive wound-healing response induced by repeated or chronic external stimuli to tissues, significantly impacting quality of life and primarily contributing to organ failure. Organ fibrosis is reported to cause 45% of all-c
Externí odkaz:
https://doaj.org/article/3b69c5d2e6cb4cce925f11611ff9ec65
Autor:
Mahya Ahmadpour Youshanlui, Amirhossein Yari, Seyedeh Zahra Bahojb Mahdavi, Mohammad Amini, Behzad Baradaran, Ramin Ahangar, Omid Pourbagherian, Amir Ali Mokhtarzadeh
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Gastric cancer remains a significant health challenge despite advancements in diagnosis and treatment. Early detection is critical to reducing mortality, necessitating the investigation of molecular mechanisms underlying gastric cancer progr
Externí odkaz:
https://doaj.org/article/d87ffa16cfad485ab4626b16ec140e67
Autor:
Di Wu, Hongli Yin, Chun Yang, Zimu Zhang, Fang Fang, Jianwei Wang, Xiaolu Li, Yi Xie, Xiaohan Hu, Ran Zhuo, Yanling Chen, Juanjuan Yu, Tiandan Li, Gen Li, Jian Pan
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone. Recently, Super-Enhancers(SEs)have been repo
Externí odkaz:
https://doaj.org/article/062afa89ce6c401580b5461a311d4c4c
Autor:
Jiaxin DU, Xinwei ZHANG
Publikováno v:
Chinese Journal of Lung Cancer, Vol 27, Iss 6, Pp 466-470 (2024)
NUT carcinoma (nuclear protein in testis carcinoma) is a rare and highly invasive malignant tumor, which is most common in midline organs and lungs. The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma famil
Externí odkaz:
https://doaj.org/article/a0cfa275526a4d7196116017481925bd
Autor:
Siying Yu, Linna Long, Xiaorui Zhang, Yu Qiu, Yabo Huang, Xueying Huang, Xia Li, Rong Xu, Chunmei Fan, He Huang
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36888- (2024)
Background: BET family proteins are important epigenetic and transcriptional regulators involved in the control of tumorigenesis and development and have become important targets for cancer therapy. However, there is no systematic bibliometric analys
Externí odkaz:
https://doaj.org/article/e8eba315ef194427952b4941856f7ae4
Autor:
Aakarsha Rao, Milan S. Stosic, Chitrasen Mohanty, Dhruthi Suresh, Albert R. Wang, Denis L. Lee, Kwangok P. Nickel, Darshan S. Chandrashekar, Randall J. Kimple, Paul F. Lambert, Christina Kendziorski, Trine B. Rounge, Gopal Iyer
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Human papillomaviruses (HPV), most commonly HPV16, are associated with a subset of head and neck squamous cell carcinoma (HNSCC) tumors, primarily oropharyngeal carcinomas, with integration of viral genomes into host chromosomes associated with worse
Externí odkaz:
https://doaj.org/article/29af87b7f5044f5da49d0afc0c1ed131
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102292- (2024)
Patients suffering from BRAF mutant melanoma have tumor recurrence within merely 7 months of treatment with a potent BRAF inhibitor (BRAFi) like vemurafenib. It has been proven that diverse molecular pathways driving BRAFi resistance converge to acti
Externí odkaz:
https://doaj.org/article/24f54a3de91540fbbc9a798eb30be707