Zobrazeno 1 - 10
of 1 249
pro vyhledávání: '"BRCA1 Gene"'
Publikováno v:
Current Oncology, Vol 31, Iss 11, Pp 6767-6777 (2024)
The lifetime risk of breast and ovarian cancer increases substantially for individuals with mutations in BRCA1/2. The evidence indicates that BRCA1/2 mutation carriers benefit from early cancer detection and prevention strategies. However, data on th
Externí odkaz:
https://doaj.org/article/153c231351304580b5ff1462c0c95298
Autor:
Liliana-Georgiana Grigore, Viorica-Elena Radoi, Alexandra Serban, Adina Daniela Mihai, Ileana Stoica
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4630-4645 (2024)
The objective of this study was to identify and classify the spectrum of mutations found in the BRCA1 and BRCA2 genes associated with breast and ovarian cancer in female patients in Romania. Germline BRCA1 and BRCA2 mutations were investigated in a c
Externí odkaz:
https://doaj.org/article/ebc12e26e0db4ac0912a59aed01a3115
Autor:
Marcelo Moreno, Júlia Salles Oliveira, Rafael Canfield Brianese, Douglas Guedes deCastro, Solange Moraes Sanches, Giovana Tardin Torrezan, Karina Miranda Santiago, Marina De Brot, Vladmir Claudio Cordeiro de Lima, Fabiana Baroni Alves Makdissi, Jose Claudio Casali Da Rocha, Vinicius Fernando Calsavara, Dirce Maria Carraro
Publikováno v:
Cancer Medicine, Vol 12, Iss 15, Pp 16129-16141 (2023)
Abstract Background Triple‐negative breast cancer (TNBC) is the neoplasia most associated with BRCA1 germline pathogenic variants (PV) and is more likely to develop metastases than the other breast cancer (BC) subtypes, mainly in the lungs and the
Externí odkaz:
https://doaj.org/article/1f3b0e4ff1c04d46929aef65802f7c1a
Publikováno v:
The Application of Clinical Genetics, Vol Volume 16, Pp 83-87 (2023)
Amina Scherz,1 Susanna Stoll,2 Benno Rothlisberger,3 Manuela Rabaglio1 1Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; 2Department of Medical Oncology, University Hospital and Stadtspital
Externí odkaz:
https://doaj.org/article/28c8902dec884566ac44464d998c3b04
Autor:
Tala Ismail, Safa Alzneika, Emna Riguene, Salwa Al-maraghi, Aya Alabdulrazzak, Noof Al-Khal, Sara Fetais, Angelos Thanassoulas, Halema AlFarsi, Michail Nomikos
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 333 (2024)
The BRCA1 is a tumor suppressor gene that encodes for the BRCA1 protein, which plays a vital role in DNA repair, cell cycle regulation, and the maintenance of genomic stability. The BRCA1 protein interacts with a variety of other proteins that play e
Externí odkaz:
https://doaj.org/article/79b683efb7b3418697b3d059d3f0bf93
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Most patients with metastatic hormone sensitive prostate cancer will progress to metastatic castration-resistant prostate cancer (mCRPC); Finding a highly effective, safe treatment with low recurrence rate has important clinical implications. Herein,
Externí odkaz:
https://doaj.org/article/dbc60185dee34d908859760fc9db81f1
Publikováno v:
Chemosensors, Vol 12, Iss 1, p 4 (2023)
This work reports new analytical applications of glassy carbon electrodes (GCE) modified with a nanohybrid obtained by non-covalent functionalization of multi-walled carbon nanotubes (MWCNTs) with human immunoglobulin G (IgG) (GCE/MWCNT-IgG). We repo
Externí odkaz:
https://doaj.org/article/281a4e12326a49e6a84dd1d60bddf37f
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background Ovarian cancer (OC) is considered a leading cause of death among women with gynecological malignancies. OC, like breast cancer, shows a familial predisposition to germline mutations in genes BRCA1 or BRCA2, which have proved to pl
Externí odkaz:
https://doaj.org/article/247922d45a754f96991fdba0b6ea46b5