Novel and Potent Small Molecules against Melanoma Harboring BRAF Class I/II/III Mutants for Overcoming Drug Resistance

Autor: Eunhye Ju, Injae Shin, Eunhye Jeon, SeongShick Ryu, Wonjeong Cho, Namkyoung Kim, Ji Won Lee, Taebo Sim, Young Hoon Kim

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3783, p 3783 (2021)

Melanoma accounts for the majority of skin cancer deaths. About 50% of all melanomas are associated with BRAF mutations. BRAF mutations are classified into three classes with regard to dependency on RAF dimerization and RAS signaling. The most freque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4c897919cea02f8f40eb93625fd919
http://europepmc.org/articles/PMC8038755