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Rapamycin, a potent inhibitor of T-cell function, prevents graft rejection in murine recipients of allogeneic T-cell-depleted donor marrow [published erratum appears in Blood 1994 Jun 1;83(11):3424-5]

Autor: BR Blazar, PA Taylor, SN Sehgal, DA Vallera

Publikováno v: Blood. 83:600-609

We investigated the ability of the macrolide antifungal agent rapamycin (RAPA) to inhibit the rejection of T-cell-depleted (TCD) donor bone marrow (BM) transplanted into major histocompatibility complex (MHC)- disparate irradiated recipients. RAPA (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bd99be7c4d1812ee3ff3109067df8f0
https://doi.org/10.1182/blood.v83.2.600.bloodjournal832600

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PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells

Autor: M Hardtke-Wolenski, A Flatley, W Koestner, Jessica Herbst, BR Blazar, Martin Sauer, M Hapke, Christoph Klein, J Fruehauf, E Jaeckel, Karl Welte, Dario A. A. Vignali

Publikováno v: Blood. 117(3)

Adoptive transfer (AT) of T cells forced to express tumor-reactive T-cell receptor (TCR) genes is an attractive strategy to direct autologous T-cell immunity against tumor-associated antigens. However, clinical effectiveness has been hampered by limi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83c054e59c80c3e9c82777c92fa97da
https://pubmed.ncbi.nlm.nih.gov/21063028

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Promotion of murine marrow alloengraftment and hematopoietic recovery across the major histocompatibility barrier by administration of recombinant human interleukin-1 alpha [see comments]

Autor: BR Blazar, MB Widmer, PA Taylor, DA Vallera

Publikováno v: Blood. 80:1614-1622

Irradiated C57BL/6 (H-2b) recipients of T-cell-depleted (TCD) BALB/c (H- 2d) bone marrow (BM) and recombinant interleukin-1 alpha (IL-1 alpha) (1 microgram/d) had a significantly (P less than or equal to .006) higher 100-day actuarial survival rate,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::190599390a1d9d9042b6dc67125463fb
https://doi.org/10.1182/blood.v80.6.1614.1614

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Use of an anti-pan T-lymphocyte ricin a chain immunotoxin in steroid- resistant acute graft-versus-host disease

Autor: VS Byers, PJ Henslee, NA Kernan, BR Blazar, R Gingrich, GL Phillips, CF LeMaistre, G Gilliland, JH Antin, P Martin

Publikováno v: Blood. 75:1426-1432

Acute steroid-resistant graft-versus-host disease (AGVHD) after allogeneic bone marrow transplantation is frequently fatal. A new treatment for this T-lymphocyte-mediated condition uses an immunotoxin, H65-RTA, comprised of a monoclonal antibody that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6c37708a5aa36f5ef7f12432ce0225c
https://doi.org/10.1182/blood.v75.7.1426.bloodjournal7571426

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Improved survival and leukocyte reconstitution without detrimental effects on engraftment in murine recipients of human recombinant granulocyte colony-stimulating factor after transplantation of T-cell- depleted histoincompatible bone marrow

Autor: BR Blazar, MB Widmer, D Cosman, HM Sassenfeld, DA Vallera

Publikováno v: Blood. 74:2264-2269

In vivo administration of human recombinant granulocyte colony- stimulating factor (rG-CSF) was evaluated for effects on survival, hematologic recovery, and engraftment in an allogeneic murine bone marrow transplantation (BMT) model involving T-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d793d4cfe2844128ada244aade574df7
https://doi.org/10.1182/blood.v74.6.2264.2264

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Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation

Autor: Rs, Shapiro, Kenneth McClain, Frizzera G, Kj, Gajl-Peczalska, Jh, Kersey, Br, Blazar, Dc, Arthur, Df, Patton, Js, Greenberg, Burke B

Publikováno v: Europe PubMed Central

B cell lymphoproliferative disorders (BLPD) developed in eight patients following bone marrow transplantation (BMT) for leukemia (five patients) or immunodeficiency (three patients). Recipients of T depleted marrow from a mismatched donor were at par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff3eebcf220c9bc31c8b09571da9169
https://doi.org/10.1182/blood.v71.5.1234.1234

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In vivo administration of recombinant human granulocyte/macrophage colony-stimulating factor in acute lymphoblastic leukemia patients receiving purged autografts [see comments]

Autor: BR Blazar, JH Kersey, PB McGlave, DA Vallera, LC Lasky, RJ Haake, B Bostrom, DR Weisdorf, C Epstein, NK Ramsay

Publikováno v: Blood. 73:849-857

Based on the recent reports that recombinant human granulocyte/macrophage colony-stimulating factor (rhGM-CSF) accelerates the rate of engraftment in a variety of autologous bone marrow transplantation settings, we have investigated its effects on he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6a534032fb0f19c1fb5fecc649938ab
https://doi.org/10.1182/blood.v73.3.849.bloodjournal733849

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Restriction fragment length polymorphisms as markers of engraftment in allogeneic marrow transplantation

Autor: BR Blazar, HT Orr, DC Arthur, JH Kersey, AH Filipovich

Publikováno v: Blood. 66(6)

We have used DNA hybridization techniques employing restriction fragment length polymorphisms (RFLPs) to quantitate the level of donor cell engraftment in bone marrow transplantation recipients. The genetic origin of the bone marrow cells and various

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c4d0b6a2176d66500158b791b36743
https://pubmed.ncbi.nlm.nih.gov/2998513

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