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Publikováno v: Europe PubMed Central

Deep venous thrombosis is initiated primarily in the pockets of the valves of the veins of the lower limbs and the main pelvic veins. In addition to a genetic predisposition there are several acquired conditions associated with deep venous thrombosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ddf53269156f66be1198d041ab388883
https://pubmed.ncbi.nlm.nih.gov/10378318

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Vitronectin modulates glycosaminoglycan dependent reactions of protein C inhibitor

Autor: Seiffert D, Margarethe Geiger, Ecke S, Br, Binder

Publikováno v: Europe PubMed Central

Protein C inhibitor (PCI), a glycosaminoglycan (GAG) dependent serine protease inhibitor, inhibits its target proteases by forming SDS-stable 1:1 complexes. GAGs alter target enzyme specificity of PCI in such a way that e.g. urokinase (uPA) is the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3fa6c0f56458cb52a28d6ed555e106d3
https://pubmed.ncbi.nlm.nih.gov/1283793

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Polar secretion of endothelin-1 by cultured endothelial cells

Autor: Of, Wagner, Christ G, Johann Wojta, Vierhapper H, Parzer S, Pj, Nowotny, Schneider B, Waldhäusl W, Br, Binder

Publikováno v: Europe PubMed Central

The aim of this study was to determine the permeability of endothelial monolayers for endothelin-1 and a possible directionality of the endothelin-1 secretion process. Human umbilical vein endothelial cells were cultured on acellular amniotic membran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a2a6ee070f22cdba7b1b07c7664ef069
https://pubmed.ncbi.nlm.nih.gov/1644793

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Reduction in pO2 decreases the fibrinolytic potential of cultured bovine endothelial cells derived from pulmonary arteries and lung microvasculature

Autor: Johann Wojta, Rl, Jones, Br, Binder, Rl, Hoover

Publikováno v: Europe PubMed Central

The effect of anoxia on the fibrinolytic potential of cultured endothelial cells derived from bovine pulmonary artery and bovine lung microvasculature was studied. Both cell types reacted with an increase in plasminogen activator inhibitor (PAI) acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2219f272c8e860a7b82473131120d585
https://doi.org/10.1182/blood.v71.6.1703.bloodjournal7161703

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A comparison between activated protein C and des-1-41-light chain- activated protein C in reactions with type 1 plasminogen activator inhibitor

Autor: CL Gladson, RR Schleef, BR Binder, DJ Loskutoff, JH Griffin

Publikováno v: Blood. 74:173-181

This study investigates the role of the gamma-carboxyglutamic acid (gla) containing domain of activated protein C in interactions with both platelet-derived and purified type 1 plasminogen activator inhibitor (PAI-1). The activity of human platelet P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c5a904465c53388dabbfe9795a295d2
https://doi.org/10.1182/blood.v74.1.173.bloodjournal741173

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Plasminogen activation in diabetes mellitus. Kinetics of plasmin formation with tissue plasminogen activator and plasminogen from individual diabetic donors and with in vitro glucosylated plasminogen

Autor: Margarethe Geiger, Br, Binder

Publikováno v: Europe PubMed Central

Functional abnormalities of tissue plasminogen activator (t-PA) (high Km in the presence of fibrin) and plasminogen (Pg) (substrate inhibition in the fibrin-stimulated system) from uncontrolled type I diabetics are reversible upon normalization of me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cf2d2a16f3568f0d14638f11bc1e5b4e
https://pubmed.ncbi.nlm.nih.gov/2971532

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Functional characterization of monoclonal antibodies directed against fibrin binding domains of tissue-type plasminogen activator

Autor: Johann Wojta, Beckmann R, Turcu L, Of, Wagner, Aj, Zonneveld, Br, Binder

Publikováno v: Europe PubMed Central

Fibrin interacts with tissue-type plasminogen activator (tPA) via the finger and the kringle 2 domains. Three monoclonal antibodies against tPA, designated MPW3VPA, MPW6VPA, and MPW7VPA, which react with epitopes in the tPA molecule involved in fibri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::62b3b8a7bfcb269c66c9a52a12b2a33d
https://pubmed.ncbi.nlm.nih.gov/2470738

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