Zobrazeno 1 - 10 of 536 pro vyhledávání: '"BP Morgan"'
1
ADNKA overcomes SARS-CoV2-mediated NK cell inhibition through non-spike antibodies
Autor: CA Fielding, P Sabberwal, JC Williamson, EJD Greenwood, TWM Crozier, W Zelek, J Seow, C Graham, I Huettner, JD Edgeworth, D Price, BP Morgan, K Ladell, M Eberl, IR Humphreys, B Merrick, K Doores, SJ Wilson, PJ Lehner, ECY Wang, RJ Stanton
The outcome of infection is dependent on the ability of viruses to manipulate the infected cell to evade immunity, and the ability of the immune response to overcome this evasion. Understanding this process is key to understanding pathogenesis, genet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf0a5d918f62649dcec327d6a21d9f50
https://doi.org/10.1101/2021.04.06.438630
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2
The AMD-associated complement factor H (CFH) polymorphism Y402H results in decreased CFH localisation to Bruch’s membrane
Autor: Aj Day, Sj Clark, Bp Morgan, I Zambrano, P. N. Bishop, S Hakobyan
Publikováno v: Acta Ophthalmologica. 87
Purpose CFH down-regulates the alternative pathway of the complement system by binding to polyanionic structures on host cells/tissues and inactivating surface associated C3b. Recently, the Y402H polymorphism in CFH has been shown to be a major risk
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e8b7641bc89205f4ace57b35af98d07
https://doi.org/10.1111/j.1755-3768.2009.2222.x
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3
Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis
Autor: Denise Vilarinho Tambourgi, Bp, Morgan, Rm, Andrade, Fc, Magnoli, Cw, Den Berg
Publikováno v: Europe PubMed Central
Loxosceles is the most venomous spider in Brazil, and envenomation causes dermonecrosis and complement (C)-dependent intravascular hemolysis. The authors studied the mechanism of induction of C-induced hemolysis. Purified Loxosceles toxins rendered h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c57b7b501bc9dbaf9948c58e3e8e8571
https://pubmed.ncbi.nlm.nih.gov/10627480
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4
Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis
Autor: Sj, Piddlesden, Mk, Storch, Hibbs M, Am, Freeman, Hans Lassmann, Bp, Morgan
Publikováno v: Europe PubMed Central
Activation of complement may contribute to tissue damage in many inflammatory diseases, including those that are clearly T cell driven. We have previously provided evidence that C is involved in tissue damage in multiple sclerosis and in the animal m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7a97c9cd3446102a05f95ed8c11c764f
https://pubmed.ncbi.nlm.nih.gov/8189065
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6
Regulation of CD59 expression on K562 cells: effects of phorbol myristate acetate, cross-linking antibody and non-lethal complement attack
Autor: kevin james marchbank, Bp, Morgan, Cw, Den Berg
Publikováno v: Europe PubMed Central
CD59 is the major membrane attack complex of complement (MAC) inhibiting protein on human cells. Its regulation is therefore an important factor in determining the fate of cells at sites of complement activation. We have chosen the K562 erythroleukae
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::23a2a041c499df6900b362183de3a483
http://europepmc.org/abstract/med/7543447
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7
Molecular cloning, chromosomal localization, expression, and functional characterization of the mouse analogue of human CD59
Autor: Mb, Powell, kevin james marchbank, Nk, Rushmere, Cw, Den Berg, Bp, Morgan
Publikováno v: Europe PubMed Central
We have previously described the isolation and cloning of the rat analogue of the human complement inhibitor CD59 (hCD59). Using the rat CD59 (rCD59) coding region as probe, we have isolated positive cDNAs from a mouse kidney cDNA library. Sequence a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5e13931f025b48f2e10732f44ac748f9
http://europepmc.org/abstract/med/9029105
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8
Akademický článek
In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor.
Autor: Sukhun R; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Cremin P; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Xu D; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Zamora J; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Cheung J; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Ashcraft L; Department of Medicinal Chemistry, Cytokinetics, Inc, South San Francisco, California, USA., Grillo MP; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, California, USA., Morgan BP; Research and Non-Clinical Development, Cytokinetics, Inc, South San Francisco, California, USA.
Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2024 Sep; Vol. 54 (9), pp. 686-700. Date of Electronic Publication: 2024 Aug 09.
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9
Akademický článek
Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [ 14 C]aficamten following single oral dose administration to rats.
Autor: Grillo MP; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, CA, USA., Sukhun R; Department of Drug Metabolism and Pharmacokinetics, Cytokinetics, Inc, South San Francisco, CA, USA., Bashir M; Labcorp Early Development Laboratories Incorporated, Madison, WI, USA., Ashcraft L; Department of Medicinal Chemistry, Cytokinetics, Inc, South San Francisco, CA, USA., Morgan BP; Research and Non-Clinical Development, Cytokinetics, Inc, South San Francisco, CA, USA.
Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2024 Sep; Vol. 54 (9), pp. 670-685. Date of Electronic Publication: 2024 Aug 07.
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10
Akademický článek
Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer's disease mouse model.
Autor: Zelek WM; UK Dementia Research Institute Cardiff, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK., Bevan RJ; UK Dementia Research Institute Cardiff, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK., Nimmo J; UK Dementia Research Institute Cardiff, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK., Dewilde M; Therapeutic and Diagnostic Antibodies, Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven 3000, Belgium.; PharmAbs, the KU Leuven Antibody Center, KU Leuven, Leuven 3000, Belgium., De Strooper B; KU Leuven and VIB Leuven, Leuven 3000, Belgium.; UK Dementia Research Institute, University College London, London WC1E 6BT, UK., Morgan BP; UK Dementia Research Institute Cardiff, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.
Publikováno v: Brain : a journal of neurology [Brain] 2024 Aug 31. Date of Electronic Publication: 2024 Aug 31.
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