Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3 beta and Tau-Aggregation Inhibitors

Autor: Gandini A, Bartolini M, Tedesco D, Martinez-Gonzalez L, Roca C, Campillo NE, Zaldivar-Diez J, Perez C, Zuccheri G, Miti A, Feoli A, Castellano S, Petralla S, Monti B, Rossi M, Moda F, Legname G, Martinez A, Bolognesi ML

Publikováno v: Journal of medicinal chemistry 61 (2018): 7640–7656. doi:10.1021/acs.jmedchem.8b0061010.1021/acs.jmedchem.8b00610
info:cnr-pdr/source/autori:Gandini A, Bartolini M, Tedesco D, Martinez-Gonzalez L, Roca C, Campillo NE, Zaldivar-Diez J, Perez C, Zuccheri G, Miti A, Feoli A, Castellano S, Petralla S, Monti B, Rossi M, Moda F, Legname G, Martinez A, Bolognesi ML/titolo:Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3 beta and Tau-Aggregation Inhibitors/doi:10.1021%2Facs.jmedchem.8b0061010.1021%2Facs.jmedchem.8b00610/rivista:Journal of medicinal chemistry/anno:2018/pagina_da:7640/pagina_a:7656/intervallo_pagine:7640–7656/volume:61

Several findings propose the altered tau protein network as an important target for Alzheimer's disease (AD). Particularly, two points of pharmacological intervention can be envisaged: inhibition of phosphorylating tau kinase GSK-3? and tau aggregati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::9cce7dd9e5c7b60c33c184ab24673788

Memoquin, a novel multifunctional compound for Alzheimer’s disease: an up-date on preclinical studies

Autor: CAPSONI, SIMONA, CATTANEO, ANTONINO, ANDRISANO V, BARTOLINI M, BOLOGNESI ML, CAVALLI A, MARGOTTI E, MELCHIORRE C, RECANATINI M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2f14c42a181fbb34632d1a44efaec424
https://hdl.handle.net/11384/7240

Memoquin: a new compound to attack Alzheimer disease on multiple fronts

Autor: CAVALLI A, BOLOGNESI ML, BARTOLINI M, ANDRISANO V, MELCHIORRE C, RECANATINI M, CAPSONI, SIMONA, CATTANEO, ANTONINO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4054::e741f9b38b35b58da896510d6bb1a555
https://hdl.handle.net/11384/23278

Remembering Marie Curie’s legacy

Autor: Cristalli, Gloria, Bolognesi, Ml

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3707::61f3ebf2f943485b508bedb633553d7f
http://hdl.handle.net/11581/219259

Styrylquinoline derivatives as therapeutic agents in prion disease

Autor: Staderini, M, Cabezas, N, Bolognesi, Ml, Legname, Giuseppe, Menéndez, Jc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______288::c15c4c4af0aa7226a11ee859258772ef
http://hdl.handle.net/20.500.11767/15546