Zobrazeno 1 - 10
of 29
pro vyhledávání: '"BOJIAO YIN"'
Autor:
Joseph L. Mertz, Shisheng Sun, Bojiao Yin, Yingwei Hu, Rahul Bhattacharya, Michael J. Bettenbaugh, Kevin J. Yarema, Hui Zhang
Publikováno v:
Bioengineering, Vol 7, Iss 4, p 144 (2020)
Comprehensive analysis of the glycoproteome is critical due to the importance of glycosylation to many aspects of protein function. The tremendous complexity of this post-translational modification, however, makes it difficult to adequately character
Externí odkaz:
https://doaj.org/article/1c807fb4aae340a19c254258294f3983
Publikováno v:
BioPharm International. Mar2023, Vol. 36 Issue 3, p18-21. 3p.
Comprehensive analysis of the glycoproteome is critical due to the widespread importance of this post-translational modification to protein function, and difficult because of the tremendous complexity it exhibits. Here we compared three glycoproteomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5d14552a4dcde00e38dbc513a27d9c
Combining Butyrated ManNAc with Glycoengineered CHO Cells Improves EPO Glycan Quality and Production
Autor:
Weiming Yang, Sandra Chough, Rahul Bhattacharya, Michael J. Betenbaugh, Qiong Wang, Yingwei Hu, Christopher T. Saeui, Cheng-Yu Chung, Kevin J. Yarema, Ganglong Yang, Bojiao Yin, Yiqun Chen, Hui Zhang
Publikováno v:
Biotechnology journal. 14(4)
Sodium butyrate (NaBu) is not only well-known for enhancing protein production, but also degrades glycan quality. In this study, butyrate supplied by the precursor molecule 1,3,4-O-Bu3 ManNAc is applied to overcome the negative effects of NaBu on gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3528ca59f58907eff7c48825633e679e
https://pubmed.ncbi.nlm.nih.gov/30221828
https://pubmed.ncbi.nlm.nih.gov/30221828
Autor:
Shuang Yang, Yuan Gao, Cheng-Yu Chung, Juechun Tang, Michael J. Betenbaugh, Mark C. Stuczynski, Bojiao Yin, Helene Faustrup Kildegaard, Hui Zhang, Emily Blake, Mikael Rørdam Andersen
Publikováno v:
Biotechnology and Bioengineering. 112:2343-2351
Sialic acid, a terminal residue on complex N-glycans, and branching or antennarity can play key roles in both the biological activity and circulatory lifetime of recombinant glycoproteins of therapeutic interest. In order to examine the impact of gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62e254f813c0a50b7dcce17df2f67fb7
https://doi.org/10.1002/bit.25650
https://doi.org/10.1002/bit.25650
Autor:
Bojiao Yin, Rahul Bhattacharya, Xiaozhi Ren, Michael J. Betenbaugh, Cheng-Yu Chung, Kevin J. Yarema, Qiong Wang
Publikováno v:
Biotechnology and bioengineering. 115(6)
The chemical additive sodium butyrate (NaBu) has been applied in cell culture media as a direct and convenient method to increase the protein expression in Chinese hamster ovary (CHO) and other mammalian cells. In this study, we examined an alternati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f7054b9d7532023fa5274547bbd5f6
https://pubmed.ncbi.nlm.nih.gov/29427449
https://pubmed.ncbi.nlm.nih.gov/29427449
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1603
Chinese hamster ovary (CHO) cells represent the predominant platform in biopharmaceutical industry for the production of recombinant biotherapeutic proteins, especially glycoproteins. These glycoproteins include oligosaccharide or glycan attachments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a907ace2df56aff76f6069d6e98b0f00
https://pubmed.ncbi.nlm.nih.gov/28493121
https://pubmed.ncbi.nlm.nih.gov/28493121
Autor:
Mertz, Joseph L., Shisheng Sun, Bojiao Yin, Yingwei Hu, Bhattacharya, Rahul, Bettenbaugh, Michael J., Yarema, Kevin J., Hui Zhang
Publikováno v:
Bioengineering (Basel); Dec2020, Vol. 7 Issue 4, p1-16, 16p
Publikováno v:
Methods in Molecular Biology ISBN: 9781493969715
Chinese hamster ovary (CHO) cells represent the predominant platform in biopharmaceutical industry for the production of recombinant biotherapeutic proteins, especially glycoproteins. These glycoproteins include oligosaccharide or glycan attachments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d9269e9eead595b8924fc55b215a6c
https://doi.org/10.1007/978-1-4939-6972-2_2
https://doi.org/10.1007/978-1-4939-6972-2_2
Autor:
Xiaozhi Ren, Rahul Bhattacharya, Cheng-Yu Chung, Qiong Wang, Michael J. Betenbaugh, Bojiao Yin, Kevin J. Yarema, Juechun Tang
Publikováno v:
Biotechnology and bioengineering. 114(8)
A desirable feature of many therapeutic glycoprotein production processes is to maximize the final sialic acid content. In this study, the effect of applying a novel chemical analog of the sialic acid precursor N-acetylmannosamine (ManNAc) on the sia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e1cdbc3d18cd216a7288a0e902e39a
https://pubmed.ncbi.nlm.nih.gov/28295160
https://pubmed.ncbi.nlm.nih.gov/28295160