A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer.

Autor: Ulrika Wendel, Nina Persson, Christian Risinger, Eva Bengtsson, Björn Nodin, Lena Danielsson, Charlotte Welinder, Gunilla Nordin Fredrikson, Bo Jansson, Ola Blixt

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0191872 (2018)

Advanced glycation end products are formed by non-enzymatic reactions between proteins and carbohydrates, causing irreversible lysine and arginine alterations that severely affect protein structure and function. The resulting modifications induce inf

Externí odkaz: https://doaj.org/article/2db164247c554e8ca49ee8ae87ae240c

A Combinatory Antibody-Antigen Microarray Assay for High-Content Screening of Single-Chain Fragment Variable Clones from Recombinant Libraries.

Autor: Nina Persson, Bo Jansson, Nicolai Stuhr-Hansen, András Kovács, Charlotte Welinder, Lena Danielsson, Ola Blixt

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168761 (2016)

We have developed a combinatory antibody-antigen microarray for direct screening of multiple single-chain fragment variable (scFv) clones with no need for pre-purification or enrichment before screening. The straightforward workflow allows for early

Externí odkaz: https://doaj.org/article/98b15b9c032b4889b0aa688d61138098

Analysis of alpha-synuclein in malignant melanoma - development of a SRM quantification assay.

Autor: Charlotte Welinder, Göran B Jönsson, Christian Ingvar, Lotta Lundgren, Bo Baldetorp, Håkan Olsson, Thomas Breslin, Melinda Rezeli, Bo Jansson, Thomas E Fehniger, Thomas Laurell, Elisabet Wieslander, Krzysztof Pawlowski, György Marko-Varga

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110804 (2014)

Globally, malignant melanoma shows a steady increase in the incidence among cancer diseases. Malignant melanoma represents a cancer type where currently no biomarker or diagnostics is available to identify disease stage, progression of disease or per

Externí odkaz: https://doaj.org/article/0f591e4e97c74574808a4d15194e4850

Primary breast cancer tumours contain high amounts of IgA1 immunoglobulin: an immunohistochemical analysis of a possible carrier of the tumour-associated Tn antigen.

Autor: Charlotte Welinder, Bo Baldetorp, Ola Blixt, Dorthe Grabau, Bo Jansson

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e61749 (2013)

The Tn antigen (GalNAc alpha-O-Ser/Thr) as defined by the binding of the lectin, helix pomatia agglutinin (HPA) or anti-Tn monoclonal antibodies, is known to be exposed in a majority of cancers, and it has also been shown to correlate positively with

Externí odkaz: https://doaj.org/article/ce89e1fb1d494899bb49525dbd1af5e7

A graphene-based glycan biosensor for electrochemical label-free detection of a tumor-associated antibody

Autor: Anna Blsakova, Peter Kasak, Jan Tkac, Monika Jerigova, Dusan Velic, Ola Blixt, Filip Kveton, Bo Jansson, Lenka Lorencova

Publikováno v: Kveton, F, Blsakova, A, Lorencova, L, Jerigova, M, Velic, D, Blixt, O, Jansson, B, Kasak, P & Tkac, J 2019, ' A Graphene-Based Glycan Biosensor for Electrochemical Label-Free Detection of a Tumor-Associated Antibody ', Sensors, vol. 19, no. 24, 5409, pp. 1-13 . https://doi.org/10.3390/s19245409
Sensors
Volume 19
Issue 24
Sensors (Basel, Switzerland)

The study describes development of a glycan biosensor for detection of a tumor-associated antibody. The glycan biosensor is built on an electrochemically activated/oxidized graphene screen-printed electrode (GSPE). Oxygen functionalities were subsequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4504f4deab761ef89feac13f1bf88cd
https://hdl.handle.net/10576/13580